Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hannes Brehm"'
Autor:
Hannes Brehm, Rainer Fischer, Stefan Barth, Dmitrij Hristodorov, Judith Niesen, Alessa Pardo, Radoslav Mladenov, Mehmet Kemal Tur
Publikováno v:
Cancer Letters. 365:149-155
The treatment of rhabdomyosarcoma (RMS) is challenging, and the prognosis remains especially poor for high-grade RMS with metastasis. The conventional treatment of RMS is based on multi-agent chemotherapy combined with resection and radiotherapy, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7266614ba1b4604caaba9cd5bb428f06
https://doi.org/10.1016/j.canlet.2015.04.004
https://doi.org/10.1016/j.canlet.2015.04.004
Autor:
Stefan Barth, Theophilus Thepen, Judith Niesen, Fabian Philipp Kreutzer, Edgar Jost, Lea Hein, Christoph Stein, Hannes Brehm, Tim Stroisch, Dmitrij Hristodorov, Radoslav Mladenov, Rainer Fischer, Tim H. Brümmendorf, Christian Cremer, Bernhard Stockmeyer, Tobias Blume
Publikováno v:
International Journal of Cancer. 137:2729-2738
Antibody-based immunotherapy of leukemia requires the targeting of specific antigens on the surface of blasts. The Fc gamma receptor (CD64) has been investigated in detail, and CD64-targeting immunotherapy has shown promising efficacy in the targeted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f36a9c929314ac8c7968e471b6e2740
https://doi.org/10.1002/ijc.29628
https://doi.org/10.1002/ijc.29628
Autor:
Stefan Barth, Hannes Brehm, Dmitrij Hristodorov, Theo Thepen, Radoslav Mladenov, Rainer Fischer
Publikováno v:
mAbs. 6:1283-1289
Tumor necrosis factor (TNF) is a pro-inflammatory cytokine that plays a critical role in many inflammatory diseases. Soluble TNF can be neutralized by monoclonal antibodies (mAbs), and this is a widely-used therapeutic approach. However, some patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3787deff311a3ea3bbf54c86f4c3a69
https://doi.org/10.4161/mabs.32182
https://doi.org/10.4161/mabs.32182
Autor:
Judith Niesen, Grit Hehmann-Titt, Rolf Fendel, Hannes Brehm, Christoph Stein, Rainer Fischer, Stefan Barth, Georg Melmer
Publikováno v:
Journal of cancer research and clinical oncology. 141(12)
The epidermal growth factor receptor (EGFR) is overexpressed in many solid tumors. EGFR-specific monoclonal antibodies (mAbs), such as cetuximab and panitumumab, have been approved for the treatment of colorectal and head and neck cancer. To increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2014f26ae812ddf48ce5d0b4e3aa0ce1
https://pubmed.ncbi.nlm.nih.gov/25899161
https://pubmed.ncbi.nlm.nih.gov/25899161
Autor:
Wijnand Helfrich, Rainer Fischer, Judith Niesen, Stefan Barth, Hannes Brehm, Georg H. Fey, Radoslav Mladenov, Christoph Stein, Stefan Gattenlöhner, Alessa Pardo
Publikováno v:
Cancer letters, 352(2), 228-235. ELSEVIER IRELAND LTD
The treatment of rhabdomyosarcoma (RMS) remains challenging, with metastatic and alveolar RMS offering a particularly poor prognosis. Therefore, the identification and evaluation of novel antigens, which are suitable targets for immunotherapy, is one
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2799ea3b1b751eb8479f2554a5941abe
https://research.rug.nl/en/publications/787d4fff-4fbe-4c6e-b1ec-9b8e2a0edc39
https://research.rug.nl/en/publications/787d4fff-4fbe-4c6e-b1ec-9b8e2a0edc39
Autor:
Niklas Tenhaef, Manal Amoury, Wijnand Helfrich, Hannes Brehm, Judith Niesen, Thomas Nachreiner, Stefan Barth, Jenny Fitting, Stefan Gattenlöhner, Tobias Blume, Alessa Pardo
Publikováno v:
Current pharmaceutical design. 19(30)
Although current cancer treatment strategies are highly aggressive, they are often not effective enough to destroy the collectivity of malignant cells. The residual tumor cells that survived the first-line treatment may continue to proliferate or eve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2524e191cedd069ba2f1cca6a750818
https://pubmed.ncbi.nlm.nih.gov/23431985
https://pubmed.ncbi.nlm.nih.gov/23431985
Autor:
Timo Kirschstein, Erika Sadkiewicz, Gerda Hund-Göschel, Juliane Becker, Xiati Guli, Steffen Müller, Marco Rohde, Dora-Charlotte Hübner, Hannes Brehme, Stephan Kolbaske, Katrin Porath, Tina Sellmann, Annette Großmann, Matthias Wittstock, Steffen Syrbe, Alexander Storch, Rüdiger Köhling
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 12 (2020)
PurposeWe present a case of voltage-gated potassium channel (VGKC) complex antibody-positive limbic encephalitis (LE) harboring autoantibodies against Kv1.2. Since the patient responded well to immunotherapy, the autoantibodies were regarded as patho
Externí odkaz:
https://doaj.org/article/c2833c7d44c24ad8a9270b2b7c640387
Autor:
Felix Schulze, Steffen Müller, Xiati Guli, Lukas Schumann, Hannes Brehme, Till Riffert, Marco Rohde, Doreen Goerss, Simone Rackow, Anne Einsle, Timo Kirschstein, Rüdiger Köhling
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
PurposeEpilepsy therapy is currently based on anti-seizure drugs that do not modify the course of the disease, i.e., they are not anti-epileptogenic in nature. Previously, we observed that in vivo casein kinase 2 (CK2) inhibition with 4,5,6,7-tetrabr
Externí odkaz:
https://doaj.org/article/a549a4bd1146428f822827468387da25
Autor:
Robert Schulz, Timo Kirschstein, Hannes Brehme, Katrin Porath, Ulrike Mikkat, Rüdiger Köhling
Publikováno v:
Neurobiology of Disease, Vol 45, Iss 1, Pp 337-347 (2012)
Hippocampal CA1 pyramidal neurons generate an after-hyperpolarization (AHP) whose medium component is thought to be generated by small-conductance Ca2+-activated K+ channels (SK channels). Neuronal excitability is increased in epilepsy, and the AHP i
Externí odkaz:
https://doaj.org/article/af5aa48c42cf47b3878e72e8b8265c6a