Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hannes Bongartz"'
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Background Breast cancer is the most common cancer in women worldwide. Triple-negative breast cancer (TNBC) is especially aggressive and associated with high metastasis. The aetiology of TNBC is heterogeneous and characterised by multiple di
Externí odkaz:
https://doaj.org/article/91316673fbe84002be79eeca50094624
Autor:
Hannes Bongartz, Karen Gille, Wiebke Hessenkemper, Katharina Mandel, Marc Lewitzky, Stephan M. Feller, Fred Schaper
Publikováno v:
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-23 (2019)
Abstract Background Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for ne
Externí odkaz:
https://doaj.org/article/df55708c6ce449da8218667ca6d79df4
Publikováno v:
Journal of Neurochemistry. 157:532-549
Interleukin-6 (IL-6) is a cytokine primarily known for immune regulation. There is also growing evidence that IL-6 triggers neurogenesis and impacts neural development, both life-long occurring processes that can be impaired by early-life and adult s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f11ff5ab37455ed1b38d9a1ea1e9a8c4
https://doi.org/10.1111/jnc.15305
https://doi.org/10.1111/jnc.15305
Autor:
Melissa Fensky, Johannes Fritsch, Thomas Fischer, Fred Schaper, Stephan M. Feller, Hannes Bongartz, Claude Haan, Christian D. Muller, Katharina Mandel, Iris Behrmann, Wiebke Hessenkemper
Publikováno v:
Cellular Signalling. 35:37-47
The constitutively active Janus kinase 2 mutant Jak2-V617F is responsible for cytokine-independent growth of hematopoietic cells and the development of myeloproliferative neoplasms, such as polycythaemia vera and essential thrombocythaemia. Cells exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d866e0928a7dd58c17c2bd10c951ea82
https://doi.org/10.1016/j.cellsig.2017.03.021
https://doi.org/10.1016/j.cellsig.2017.03.021
Autor:
Fred Schaper, Karen Gille, Katharina Mandel, Stephan M. Feller, Hannes Bongartz, Marc Lewitzky, Wiebke Hessenkemper
Publikováno v:
Cell Communication and Signaling : CCS
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-23 (2019)
Cell Communication and Signaling, Vol 17, Iss 1, Pp 1-23 (2019)
Background Cytokine-dependent activation of signalling pathways is tightly orchestrated. The spatiotemporal activation of signalling pathways dictates the specific physiological responses to cytokines. Dysregulated signalling accounts for neoplastic,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108e04c51706c30b00fa321ac6ca1afa
https://doi.org/10.1186/s12964-019-0451-2
https://doi.org/10.1186/s12964-019-0451-2
Autor:
Steffen Klamt, Melissa Fensky, Sandra Heise, Hannes Bongartz, Fred Schaper, Wiebke Hessenkemper, Sven Thiele
Publikováno v:
IEEE ACM Transactions on Computational Biology and Bioinformatics
Modern methods for the inference of cellular networks from experimental data often express nondeterminism by proposing an ensemble of candidate models with similar properties. To further discriminate among these model candidates, new experiments need
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664327b338085a1c9387f9dbf755924a
https://pubmed.ncbi.nlm.nih.gov/29993657
https://pubmed.ncbi.nlm.nih.gov/29993657
Autor:
Stephan M. Feller, Alexandra Wolf, Hannes Bongartz, Sam Lievens, Fred Schaper, Philip C. Simister, René Eulenfeld, Jan Tavernier, Wiebke Hessenkemper
Publikováno v:
Cellular Signalling. 27:340-352
The timely orchestration of multiple signalling pathways is crucial for the integrity of an organism and therefore tightly controlled. Gab family proteins coordinate signal transduction at the plasma membrane (PM) by acting as docking platforms for s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1c083cf40102f2007ddb55aea9fb44
https://doi.org/10.1016/j.cellsig.2014.11.017
https://doi.org/10.1016/j.cellsig.2014.11.017
Autor:
Anna Dittrich, Valeria Poli, Nicole Wundrack, Hannes Bongartz, Fred Schaper, Oliver Klepsch, Jessica Pinno
Interleukin 6 (IL-6) is a pleiotropic cytokine and a strong activator of Mammalian Target of Rapamycin (mTOR). In contrast, mTOR activity is negatively regulated by Regulated in Development and DNA Damage Responses 1 (REDD1). Expression of REDD1 is i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2039d4b13fbb50388bf7386f7aff25ba
http://hdl.handle.net/2318/1568868
http://hdl.handle.net/2318/1568868
Autor:
Johannes Fritsch, Hannes Bongartz, Stephan M. Feller, Wiebke Hessenkemper, René Eulenfeld, Alexandra Wolf, Fred Schaper, Philip C. Simister
Publikováno v:
Cytokine. 76:75
The timely orchestration of multiple signalling pathways is crucial for the integrity of organisms and therefore tightly controlled. Gab family proteins coordinate signal transduction at the plasma membrane by acting as docking platforms for signalli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee66ea816e96eada4ef1969c49470324
https://doi.org/10.1016/j.cyto.2015.08.088
https://doi.org/10.1016/j.cyto.2015.08.088
Autor:
Fred Schaper, Stephan M. Feller, Philip C. Simister, Hannes Bongartz, René Eulenfeld, Jan Tavernier, Iris Behrmann, Alexandra Wolf, Wiebke Hessenkemper, Claude Haan
Publikováno v:
Cytokine. 76:80
The activating JAK2-V617F mutation is found in many patients suffering from Myeloproliferative neoplasms such as Polycythemia Vera and Essential Thrombocythemia. JAK2-V617F mutation confers cytokine hypersensitivity, constitutive activation of the JA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c74df0248cf4d4b4d149f9e7b3807a5
https://doi.org/10.1016/j.cyto.2015.08.109
https://doi.org/10.1016/j.cyto.2015.08.109