Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hannes Ausserwöger"'
Autor:
Mrityunjoy Kar, Laura T. Vogel, Gaurav Chauhan, Suren Felekyan, Hannes Ausserwöger, Timothy J. Welsh, Furqan Dar, Anjana R. Kamath, Tuomas P. J. Knowles, Anthony A. Hyman, Claus A. M. Seidel, Rohit V. Pappu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Phase separation and percolation contribute to phase transitions of multivalent macromolecules. Contributions of percolation are evident through the viscoelasticity of condensates and through the formation of heterogeneous distributions of n
Externí odkaz:
https://doaj.org/article/12c6a6e070804665adbd0503a07d444e
Autor:
Tomas Sneideris, Nadia A. Erkamp, Hannes Ausserwöger, Kadi L. Saar, Timothy J. Welsh, Daoyuan Qian, Kai Katsuya-Gaviria, Margaret L. L. Y. Johncock, Georg Krainer, Alexander Borodavka, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Antimicrobial peptides (AMPs), which combat bacterial infections by disrupting the bacterial cell membrane or interacting with intracellular targets, are naturally produced by a number of different organisms, and are increasingly also explor
Externí odkaz:
https://doaj.org/article/f347a58e300d44799db612aff9c099ee
Autor:
Nadia A. Erkamp, Tomas Sneideris, Hannes Ausserwöger, Daoyuan Qian, Seema Qamar, Jonathon Nixon-Abell, Peter St George-Hyslop, Jeremy D. Schmit, David A. Weitz, Tuomas P. J. Knowles
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Biomolecular condensates with internal structure allow cells to further organise their processes. In this work the authors investigate how condensates can obtain an internal structure with droplets of dilute phase inside via kinetic, rather than pure
Externí odkaz:
https://doaj.org/article/7c07f116ca21498c96519569ce628d42
Autor:
Hannes Ausserwöger, Matthias M. Schneider, Therese W. Herling, Paolo Arosio, Gaetano Invernizzi, Tuomas P. J. Knowles, Nikolai Lorenzen
Publikováno v:
Nature Reviews Chemistry. 6:844-861
Solubility is a property of central importance for the use of proteins in research in molecular and cell biology and in applications in biotechnology and medicine. Since experimental methods for measuring protein solubility are material intensive and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c9b32206ce6b2c7dc4bd0284c81979
https://www.repository.cam.ac.uk/handle/1810/345594
https://www.repository.cam.ac.uk/handle/1810/345594
Autor:
Tomas Sneideris, Nadia A. Erkamp, Hannes Ausserwöger, Kadi L. Saar, Timothy J. Welsh, Daoyuan Qian, Margaret L. L. Y. Johncock, Georg Krainer, Alexander Borodavka, Tuomas P. J. Knowles
Antimicrobial peptides (AMPs) are a vital part of the immune system that helps combat bacterial infections by disrupting the bacterial cell membrane or interacting with intracellular targets. However, the mechanisms by which AMPs act on intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c1f0a5a5dab663f131e2ada8eb05d1b2
https://doi.org/10.1101/2023.03.11.532143
https://doi.org/10.1101/2023.03.11.532143
Autor:
Therese W. Herling, Gaetano Invernizzi, Hannes Ausserwöger, Jais Rose Bjelke, Thomas Egebjerg, Søren Lund, Nikolai Lorenzen, Tuomas P. J. Knowles
Monoclonal antibodies (mAbs) have successfully been developed for the treatment of a wide range of diseases. The clinical success of mAbs, does not solely rely on optimal potency and safety, but also require good biophysical properties to ensure high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ddbfceb62dbff9cd5302d6fadd88853
https://doi.org/10.1101/2023.02.13.528263
https://doi.org/10.1101/2023.02.13.528263
Autor:
Nadia A. Erkamp, Mina Farag, Daoyuan Qian, Tomas Sneideris, Timothy J. Welsh, Hannes Ausserwöger, David A. Weitz, Rohit V. Pappu, Tuomas P. J. Knowles
Biomolecular condensates form via spontaneous and driven phase transitions of multivalent proteins and nucleic acids. These macromolecules can be organized in spatially inhomogeneous ways that lead to multiple coexisting dense phases with distinct ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785e48dd376a272a10e30de2cd362cc7
https://doi.org/10.1101/2023.01.12.523837
https://doi.org/10.1101/2023.01.12.523837
Autor:
Hannes Ausserwöger, Georg Krainer, Daoyuan Qian, Timothy Welsh, Tomas Sneideris, Matthias M. Schneider, Gaetano Invernizzi, Therese W. Herling, Nikolai Lorenzen, Tuomas P. Knowles
Publikováno v:
Biophysical Journal. 122:158a
Autor:
Hannes Ausserwöger, Georg Krainer, Timothy J. Welsh, Tomas Sneideris, Matthias M. Schneider, Gaetano Invernizzi, Therese W. Herling, Nikolai Lorenzen, Tuomas P. J. Knowles
Non-specificity is a key challenge in the successful development of therapeutic antibodies. The tendency for non-specific binding in antibodies is often difficult to reduce via judicious design and, instead, it is necessary to rely on comprehensive s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7066603b68167ead4577dfe94b4b83ab
https://doi.org/10.1101/2022.03.07.483238
https://doi.org/10.1101/2022.03.07.483238