Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Hannes, Link"'
Autor:
Mohammad Saba Yousef Mardoukhi, Johanna Rapp, Iker Irisarri, Katrin Gunka, Hannes Link, Jan Marienhagen, Jan deVries, Jörg Stülke, Fabian M. Commichau
Publikováno v:
Microbial Biotechnology, Vol 17, Iss 3, Pp n/a-n/a (2024)
Abstract Glutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT). The glutamate dehydrogenases are devoted to gluta
Externí odkaz:
https://doaj.org/article/a39528901f3b4014960369f68d7aaeba
Autor:
Roee Ben Nissan, Eliya Milshtein, Vanessa Pahl, Benoit de Pins, Ghil Jona, Dikla Levi, Hadas Yung, Noga Nir, Dolev Ezra, Shmuel Gleizer, Hannes Link, Elad Noor, Ron Milo
Publikováno v:
eLife, Vol 12 (2024)
Synthetic autotrophy is a promising avenue to sustainable bioproduction from CO2. Here, we use iterative laboratory evolution to generate several distinct autotrophic strains. Utilising this genetic diversity, we identify that just three mutations ar
Externí odkaz:
https://doaj.org/article/1fc03bff24fc41188474d60ea9ff38d4
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract The operation of the central metabolism is typically assumed to be deterministic, but dynamics and high connectivity of the metabolic network make it potentially prone to generating fluctuations. However, time-resolved measurements of metabo
Externí odkaz:
https://doaj.org/article/820dc7211e804bf58ed04f2b27b6e93d
Autor:
Thorben Schramm, Paul Lubrano, Vanessa Pahl, Amelie Stadelmann, Andreas Verhülsdonk, Hannes Link
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 10, Pp n/a-n/a (2023)
Abstract Temperature‐sensitive (TS) mutants are a unique tool to perturb and engineer cellular systems. Here, we constructed a CRISPR library with 15,120 Escherichia coli mutants, each with a single amino acid change in one of 346 essential protein
Externí odkaz:
https://doaj.org/article/bdb550e782454880bb045c1aa6d4bd75
Autor:
Martina Hauke, Felix Metz, Johanna Rapp, Larissa Faass, Simon H. Bats, Sandra Radziej, Hannes Link, Wolfgang Eisenreich, Christine Josenhans
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Heptose metabolites including ADP-d-glycero-β-d-manno-heptose (ADP-heptose) are involved in bacterial lipopolysaccharide and cell envelope biosynthesis. Recently, heptoses were also identified to have potent proinflammatory activity on huma
Externí odkaz:
https://doaj.org/article/6bfe2c934cc848208d93214055eee2fb
Autor:
Sophia Krauss, Theresa A. Harbig, Johanna Rapp, Timm Schaefle, Mirita Franz-Wachtel, Leonie Reetz, Ahmed M. A. Elsherbini, Boris Macek, Stephanie Grond, Hannes Link, Kay Nieselt, Bernhard Krismer, Andreas Peschel, Simon Heilbronner
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous divers
Externí odkaz:
https://doaj.org/article/fb2900638a02438e90f389423ed3b167
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Synthetic pathways represent a metabolic burden on host cells. Here the authors engineer Cra-binding sites to prevent misregulation in glycerol and carotenoid overproducing E. coli strains.
Externí odkaz:
https://doaj.org/article/e191ae102d374078b676c6a807f7a206
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The accumulation of the compatible solute L-proline by Bacillus subtilis via synthesis is a cornerstone in the cell’s defense against high salinity as the genetic disruption of this biosynthetic process causes osmotic sensitivity. To understand how
Externí odkaz:
https://doaj.org/article/35f07645e0c54e449b1f00eac3bd1034
Publikováno v:
Biology, Vol 12, Iss 2, p 159 (2023)
Dormancy and resuscitation are key to bacterial survival under fluctuating environmental conditions. In the absence of combined nitrogen sources, the non-diazotrophic model cyanobacterium Synechocystis sp. PCC 6803 enters into a metabolically quiesce
Externí odkaz:
https://doaj.org/article/a0d02a18db9043249cd94745ec64d74a
Autor:
Valentina Goldfinger, Marius Spohn, Jens-Peter Rodler, Melanie Sigle, Andreas Kulik, Max J. Cryle, Johanna Rapp, Hannes Link, Wolfgang Wohlleben, Evi Stegmann
Publikováno v:
Metabolic Engineering. 78:84-92