Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Hannes, Braberg"'
Autor:
Ujjwal Rathore, Paige Haas, Vigneshwari Easwar Kumar, Joseph Hiatt, Kelsey M. Haas, Mehdi Bouhaddou, Danielle L. Swaney, Erica Stevenson, Lorena Zuliani-Alvarez, Michael J. McGregor, Autumn Turner-Groth, Charles Ochieng' Olwal, Yaw Bediako, Hannes Braberg, Margaret Soucheray, Melanie Ott, Manon Eckhardt, Judd F. Hultquist, Alexander Marson, Robyn M. Kaake, Nevan J. Krogan
Publikováno v:
mBio, Vol 15, Iss 4 (2024)
ABSTRACTDuring HIV infection of CD4+ T cells, ubiquitin pathways are essential to viral replication and host innate immune response; however, the role of specific E3 ubiquitin ligases is not well understood. Proteomics analyses identified 116 single-
Externí odkaz:
https://doaj.org/article/a68bf9f80cd74600b676bdd895184026
Autor:
Kelsey M. Haas, Michael J. McGregor, Mehdi Bouhaddou, Benjamin J. Polacco, Eun-Young Kim, Thong T. Nguyen, Billy W. Newton, Matthew Urbanowski, Heejin Kim, Michael A. P. Williams, Veronica V. Rezelj, Alexandra Hardy, Andrea Fossati, Erica J. Stevenson, Ellie Sukerman, Tiffany Kim, Sudhir Penugonda, Elena Moreno, Hannes Braberg, Yuan Zhou, Giorgi Metreveli, Bhavya Harjai, Tia A. Tummino, James E. Melnyk, Margaret Soucheray, Jyoti Batra, Lars Pache, Laura Martin-Sancho, Jared Carlson-Stevermer, Alexander S. Jureka, Christopher F. Basler, Kevan M. Shokat, Brian K. Shoichet, Leah P. Shriver, Jeffrey R. Johnson, Megan L. Shaw, Sumit K. Chanda, Dan M. Roden, Tonia C. Carter, Leah C. Kottyan, Rex L. Chisholm, Jennifer A. Pacheco, Maureen E. Smith, Steven J. Schrodi, Randy A. Albrecht, Marco Vignuzzi, Lorena Zuliani-Alvarez, Danielle L. Swaney, Manon Eckhardt, Steven M. Wolinsky, Kris M. White, Judd F. Hultquist, Robyn M. Kaake, Adolfo García-Sastre, Nevan J. Krogan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-27 (2023)
Abstract Influenza A Virus (IAV) is a recurring respiratory virus with limited availability of antiviral therapies. Understanding host proteins essential for IAV infection can identify targets for alternative host-directed therapies (HDTs). Using aff
Externí odkaz:
https://doaj.org/article/6403bbe7a8b6480aacd27d46627e36f2
Autor:
Fernando Meza Gutierrez, Deniz Simsek, Arda Mizrak, Adam Deutschbauer, Hannes Braberg, Jeffrey Johnson, Jiewei Xu, Michael Shales, Michelle Nguyen, Raquel Tamse-Kuehn, Curt Palm, Lars M Steinmetz, Nevan J Krogan, David P Toczyski
Publikováno v:
eLife, Vol 7 (2018)
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in Saccharomyces cerevisiae. To uncover pathways regulated by distinct linkages, genetic in
Externí odkaz:
https://doaj.org/article/f07665d4c7984c8e8770d5baaa41a25f
Publikováno v:
FEBS J
Integrative structure modeling is increasingly used for determining the architectures of biological assemblies, especially those that are structurally heterogeneous. Recently, we reported on how to convert in vivo genetic interaction measurements int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b81deb415a80960f9bca54d32b19e33
https://doi.org/10.1111/febs.16435
https://doi.org/10.1111/febs.16435
Publikováno v:
Nature Reviews. Genetics
Nature reviews. Genetics, vol 23, iss 6
Nature reviews. Genetics, vol 23, iss 6
Understanding the effects of genetic variation is a fundamental problem in biology that requires methods to analyse both physical and functional consequences of sequence changes at systems-wide and mechanistic scales. To achieve a systems view, prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5afed610579a783b48f85d1a93bf8c7
https://doi.org/10.1038/s41576-021-00441-w
https://doi.org/10.1038/s41576-021-00441-w
Autor:
Danielle L. Swaney, Christopher J.P. Mathy, Nevan J. Krogan, Tina Perica, Hannes Braberg, Yang Zhang, Noah Ollikainen, David G. Lambright, Tanja Kortemme, Jiewei Xu, Robyn M. Kaake, Gwendolyn Μ. Jang, Mark J. S. Kelly
Publikováno v:
Nature. 599:152-157
Molecular switch proteins whose cycling between states is controlled by opposing regulators1,2 are central to biological signal transduction. As switch proteins function within highly connected interaction networks3, the fundamental question arises o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fe493bc88c63c6fa6e712c326ae7fc31
https://doi.org/10.1038/s41586-021-03982-6
https://doi.org/10.1038/s41586-021-03982-6
Autor:
James E. Haber, Hannes Braberg, Qiuqin Wu, Richard Alexander, Julian Haase, Colm Ryan, Zach Lipkin-Moore, Kathleen E. Franks-Skiba, Tasha Johnson, Michael Shales, Tineke L. Lenstra, Frank C.P. Holstege, Jeffrey R. Johnson, Kerry Bloom, Nevan J. Krogan
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2168-2178 (2013)
Genetic interactions reveal the functional relationships between pairs of genes. In this study, we describe a method for the systematic generation and quantitation of triple mutants, termed triple-mutant analysis (TMA). We have used this approach to
Externí odkaz:
https://doaj.org/article/0ee5fd978f00418b9e5d751d398e6417
Autor:
Lucy G. Thorne, Mehdi Bouhaddou, Ann-Kathrin Reuschl, Lorena Zuliani-Alvarez, Ben Polacco, Adrian Pelin, Jyoti Batra, Matthew V. X. Whelan, Myra Hosmillo, Andrea Fossati, Roberta Ragazzini, Irwin Jungreis, Manisha Ummadi, Ajda Rojc, Jane Turner, Marie L. Bischof, Kirsten Obernier, Hannes Braberg, Margaret Soucheray, Alicia Richards, Kuei-Ho Chen, Bhavya Harjai, Danish Memon, Joseph Hiatt, Romel Rosales, Briana L. McGovern, Aminu Jahun, Jacqueline M. Fabius, Kris White, Ian G. Goodfellow, Yasu Takeuchi, Paola Bonfanti, Kevan Shokat, Natalia Jura, Klim Verba, Mahdad Noursadeghi, Pedro Beltrao, Manolis Kellis, Danielle L. Swaney, Adolfo García-Sastre, Clare Jolly, Greg J. Towers, Nevan J. Krogan
Publikováno v:
Nature, 602 (7897)
Nature, vol 602, iss 7897
Nature, vol 602, iss 7897
The emergence of SARS-CoV-2 variants of concern suggests viral adaptation to enhance human-to-human transmission1,2. Although much effort has focused on the characterization of changes in the spike protein in variants of concern, mutations outside of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3a384bf72e6906b25f3b629a47b07ea
Autor:
Benjamin J. Polacco, Kuei-Ho Chen, Matthew Whelan, Natalia Jura, Adolfo García-Sastre, Margaret Soucheray, Jacqueline M. Fabius, Kevan M. Shokat, Ian Goodfellow, Alicia L. Richards, Ajda Roic, Danielle L. Swaney, Myra Hosmillo, Danish Memon, Mahdad Noursadeghi, Ann-Kathrin Reuschl, Pedro Beltrao, Kirsten Obernier, Manisha Ummadi, Greg J. Towers, Kliment A. Verba, Aminu S Jahun, Nevan J. Krogan, Lorena Zuliani-Alvarez, Adrian Pelin, Jane Turner, Bhavya Harjai, Mehdi Bouhaddou, Hannes Braberg, Jyoti Batra, Lucy Thorne, Joseph Hiatt, Clare Jolly
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
Emergence of SARS-CoV-2 variants, including the globally successful B.1.1.7 lineage, suggests viral adaptations to host selective pressures resulting in more efficient transmission. Although much effort has focused on Spike adaptation for viral entry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c581a36a2f03af50c3902155bd19036
https://pubmed.ncbi.nlm.nih.gov/34942634
https://pubmed.ncbi.nlm.nih.gov/34942634
Autor:
Richard Alexander, Brian D. Strahl, Shuangying Jiang, John H. Morris, Kaitlin K. Chaung, Raghuvar Dronamraju, Shuyi Wang, James S. Fraser, Derek Bogdanoff, Stefan Bohn, James E. Haber, Peter Cimermancic, Michael Shales, Nevan J. Krogan, Anthony L. Shiver, Riccardo Pellarin, Jef D. Boeke, Hannes Braberg, David Mavor, Junbiao Dai, Jiewei Xu, Andrej Sali, Ignacia Echeverria, Joel S. Bader, Ruth Hüttenhain, Gajendradhar Dwivedi, Carol A. Gross, Dina Schneidman
Publikováno v:
Science (New York, N.Y.), vol 370, iss 6522
Science
Science
From phenotype to structure Much insight has come from structures of macromolecular complexes determined by methods such as crystallography or cryo–electron microscopy. However, looking at transient complexes remains challenging, as does determinin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d0f10bdfb513e43da5009d574b06bf
https://escholarship.org/uc/item/43n670zm
https://escholarship.org/uc/item/43n670zm