Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hannelore Simon"'
Publikováno v:
Journal of Molecular Recognition. 14:122-139
Data are presented on a triplex type with two parallel homologous strands for which triplex formation is almost as strong as duplex formation at least for some sequences and even at pH 7 and 0.2 M NaCl. The evidence mainly rests upon comparing thermo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51bf1223346be4a0b39a2a1dc62dfb39
https://doi.org/10.1002/jmr.528
https://doi.org/10.1002/jmr.528
Autor:
Christian J. Leumann, Günther Burckhardt, A. Stelzner, I. Prévot-Halter, I. Förtsch, Eckhard Birch-Hirschfeld, A. Gabrielyan, C. Zimmer, Hannelore Simon
Publikováno v:
Scopus-Elsevier
The goal of this work was to examine the effect of triple helix-forming oligonucleotides on a gyrase target region and on the activity of the enzyme. Using melting temperature measurements and gel mobility shift analysis, it was found that modified o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::161e16054b26e97f27f30c8c85bf2b13
https://doi.org/10.1089/oli.1.1999.9.527
https://doi.org/10.1089/oli.1.1999.9.527
Autor:
Hannelore Simon, Christoph Zimmer
Publikováno v:
IUBMB Life. 44:915-924
Purified subunits of DNA gyrase from Streptomyces noursei have been obtained with relatively high yield. By comparing the activity of the reconstituted enzyme (supercoiling and cleavage reaction) with other gyrase species and hybrid enzymes it is sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1da86d93a04a85c461826bb544d8099
https://doi.org/10.1080/15216549800201972
https://doi.org/10.1080/15216549800201972
Autor:
J. Störl, Roemer Ernst, Hans Triebel, Christoph Zimmer, Hannelore Simon, Axel Walter, Karin Störl, Andreas Opitz, G. Burckhardt
Publikováno v:
Biochemistry. 37:4703-4711
We have investigated the binding ability to DNA of compounds belonging to the 2-azaanthraquinone-type structure and have examined the effect on the activity of DNA gyrase as well as on mammalian topoisomerases in vitro. Using different biophysical te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f30cdb2a7b1fd34cb086880809139fe
https://doi.org/10.1021/bi9724220
https://doi.org/10.1021/bi9724220
Publikováno v:
FEBS Letters. 373:88-92
To investigate the functional equivalence of DNA gyrase subunits from different bacterial sources hybrid enzymes were formed using purified A and B subunits from three species of Streptomycetes, E. coli and B. subtilis. The activity of gyrase hybrids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b8d9c868ea363a92ea2cc03280ab431
https://doi.org/10.1016/0014-5793(95)01007-2
https://doi.org/10.1016/0014-5793(95)01007-2
Autor:
Stephan Heinze, H. Lackner, Hannelore Simon, Heike Huelsmann, Christoph Zimmer, Horst Baer, Udo Graefe
Publikováno v:
ChemInform. 31
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f346523797aa5c3d05b4dccb957b7883
https://doi.org/10.1002/chin.200023242
https://doi.org/10.1002/chin.200023242
Publikováno v:
FEBS letters. 471(2-3)
The influence of an eight-ring hairpin DNA minor groove binder on the gyrase mediated DNA supercoiling and cleavage reaction step of the enzyme was investigated. The results demonstrate that supercoiling is affected by the hairpin polyamide in the mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::923d52b2c385ad03e4c112544f07f8fe
https://pubmed.ncbi.nlm.nih.gov/10767417
https://pubmed.ncbi.nlm.nih.gov/10767417
Autor:
Stephan Heinze, Christoph Zimmer, Hannelore Simon, H. Lackner, Udo Gräfe, Heike Hülsmann, Horst Bär
Publikováno v:
The Journal of antibiotics. 53(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e633a246c47e085cc162352bc2fbd107
https://pubmed.ncbi.nlm.nih.gov/10724016
https://pubmed.ncbi.nlm.nih.gov/10724016
Publikováno v:
Biological chemistry. 377(11)
Cisplatin is a widely used anticancer agent that exerts its biological activity principally by damaging DNA. Although detailed knowledge exists concerning mechanisms that lead to cisplatin adducts in DNA, there are few insights into the processes tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a30338d479f85676715543b69c86610e
https://pubmed.ncbi.nlm.nih.gov/8960374
https://pubmed.ncbi.nlm.nih.gov/8960374
Publikováno v:
FEBS letters. 353(1)
The influence of netropsin (Nt), distamycin A (Dst-3) and chromomycin A3 (CHR) on the binding of gyrase from Streptomyces noursei to an 162 bp-fragment of pBR 322 containing a strong gyrase cleavage site and on the gyrase mediated cleavage of this fr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e1b32201074d553b5615d3d6ad79ee9
https://pubmed.ncbi.nlm.nih.gov/7926028
https://pubmed.ncbi.nlm.nih.gov/7926028