APC15 mediates CDC20 autoubiquitylation by APC/CMCC and disassembly of the mitotic checkpoint complex

Autor: Maria Novatchkova, Brenda A. Schulman, Hannelore Schutz, Jan-Michael Peters, Rene Ladurner, Nicholas G. Brown, Billy T Dye, Holger Stark, Marc A. Jarvis, Kristina Uzunova, Yusuke Toyoda, Anthony A. Hyman, Georg Petzold, Ina Poser, Karl Mechtler

Publikováno v: Nature structural & molecular biology
Nature Structural & Molecular Biology
Nature Structural & Molecular Biology; Vol 19
Nature Structural and Molecular Biology

The anaphase-promoting complex/cyclosome (APC/C) bound to CDC20 (APC/C(CDC20)) initiates anaphase by ubiquitylating B-type cyclins and securin. During chromosome bi-orientation, CDC20 assembles with MAD2, BUBR1 and BUB3 into a mitotic checkpoint comp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f5c1cca13e0cddce1764bde34022b4
https://doi.org/10.1038/nsmb.2412