Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannelore Hartmann"'
Publikováno v:
IUBMB lifeREFERENCES. 74(8)
Cholesterol is a ubiquitous and essential component of cellular membranes, as it regulates membrane structure and fluidity. Furthermore, cholesterol serves as a precursor for steroid hormones, oxysterol, and bile acids, that are essential for maintai
Publikováno v:
The FEBS journalReferences. 289(24)
Amyotrophic lateral sclerosis (ALS), the most common adult-onset motor neuron disease, is characterized by the selective degeneration of motor neurons leading to paralysis and eventual death. Multiple pathogenic mechanisms, including systemic dysmeta
Autor:
Mareike Czuppa, Meike Michaelsen, Nikola Mareljic, Hannelore Hartmann, Henrick Riemenschneider, F. Ulrich Hartl, Mark S. Hipp, Frédéric Frottin, Bahram Khosravi, Qihui Zhou, Daniel Farny, Dieter Edbauer, Thomas Arzberger, Kathrine D LaClair
Publikováno v:
The EMBO Journal, 39:e102811. Wiley
EMBO JOURNAL
The EMBO journal 39(8), e102811 (2020). doi:10.15252/embj.2019102811
The EMBO Journal
EMBO JOURNAL
The EMBO journal 39(8), e102811 (2020). doi:10.15252/embj.2019102811
The EMBO Journal
The C9orf72 repeat expansion causes amyotrophic lateral sclerosis and frontotemporal dementia, but the poor correlation between C9orf72‐specific pathology and TDP‐43 pathology linked to neurodegeneration hinders targeted therapeutic development.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43e4f1bd9cfbc715390319e28d66b75
https://research.rug.nl/en/publications/dba56011-e77e-4ed5-8c61-5a2007e2749e
https://research.rug.nl/en/publications/dba56011-e77e-4ed5-8c61-5a2007e2749e
Autor:
Dieter Edbauer, Bahram Khosravi, Dorothee Dormann, Helena Ederle, Christoph Möhl, Martin H. Schludi, Meike Michaelsen, Hannelore Hartmann, Stephanie May
Publikováno v:
Human Molecular Genetics
Human molecular genetics 26(4), ddw432 (2016). doi:10.1093/hmg/ddw432
Human molecular genetics 26(4), ddw432 (2016). doi:10.1093/hmg/ddw432
A repeat expansion in the non-coding region of C9orf72 gene is the most common mutation causing frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Sense and antisense transcripts are translated into aggregating dipeptid
Autor:
Hannelore, Hartmann, Daniel, Hornburg, Mareike, Czuppa, Jakob, Bader, Meike, Michaelsen, Daniel, Farny, Thomas, Arzberger, Matthias, Mann, Felix, Meissner, Dieter, Edbauer
Publikováno v:
Life Science Alliance
Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show
Autor:
Daniel Hornburg, Martin H. Schludi, Alessio Colombo, Simone Haupt, Albert C. Ludolph, Michael Peitz, Alperen Serdaroglu, Felix Meissner, Oliver Brüstle, Clemens Küpper, Markus Otto, Denise Orozco, Meike Michaelsen, Sabina Tahirovic, Peer-Hendrik Kuhn, Thomas Arzberger, Franziska Schreiber, Hannelore Hartmann, Dieter Edbauer, Benjamin M. Schwenk, Thomas Klopstock
Publikováno v:
The EMBO journal 35(21), 2350-2370 (2016). doi:10.15252/embj.201694221
The EMBO Journal
The EMBO Journal
Nuclear clearance of TDP‐43 into cytoplasmic aggregates is a key driver of neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), but the mechanisms are unclear. Here, we show that TDP‐43 knockdown
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::743876020a375f33cdaa77870c13234f
Autor:
Mareike Czuppa, Daniel Hornburg, Hannelore Hartmann, Thomas Arzberger, Matthias Mann, Felix Meissner, Jakob M. Bader, Meike Michaelsen, Dieter Edbauer, Daniel Farny
Publikováno v:
Life Science Alliance
Life science alliance 1(2), e201800070 (2018). doi:10.26508/lsa.201800070
Life science alliance 1(2), e201800070 (2018). doi:10.26508/lsa.201800070
Frontotemporal dementia and amyotrophic lateral sclerosis patients with C9orf72 mutation show cytoplasmic poly-GR and poly-PR aggregates. Short poly-(Gly-Arg) and poly-(Pro-Arg) (poly-GR/PR) repeats localizing to the nucleolus are toxic in various mo
Autor:
Hannelore Hartmann, Mark S. Hipp, Wolfgang Baumeister, Florian Beck, Qiang Guo, Till Rudack, Frédéric Frottin, Manuela Pérez-Berlanga, F. Ulrich Hartl, Rubén Fernández-Busnadiego, Antonio Martinez-Sanchez, Dieter Edbauer, Carina Lehmer
Publikováno v:
Cell 172(4), 696-705.e12 (2018). doi:10.1016/j.cell.2017.12.030
Cell
Cell
Protein aggregation and dysfunction of the ubiquitin-proteasome system are hallmarks of many neuro-degenerative diseases. Here, we address the elusive link between these phenomena by employing cryo-electron tomography to dissect the molecular archite
Autor:
Claudia Abou-Ajram, Tobias Madl, Dorothee Dormann, Christian Haass, Marc Suárez-Calvet, Stefan Reber, Manuela Neumann, Benjamin Bourgeois, Moritz Resch, Marc-David Ruepp, Eva B. E. Funk, Christoph Göbl, Olaf Ansorge, Ian R. A. Mackenzie, Thomas Arzberger, Dieter Edbauer, Daniel Jutzi, Hannelore Hartmann, Elisabeth Kremmer
Publikováno v:
Suárez-Calvet, Marc; Neumann, Manuela; Arzberger, Thomas; Abou-Ajram, Claudia; Funk, Eva; Hartmann, Hannelore; Edbauer, Dieter; Kremmer, Elisabeth; Göbl, Christoph; Resch, Moritz; Bourgeois, Benjamin; Madl, Tobias; Reber, Stefan; Jutzi, Daniel; Ruepp, Marc-David; Mackenzie, Ian R. A.; Ansorge, Olaf; Dormann, Dorothee; Haass, Christian (2016). Monomethylated and unmethylated FUS exhibit increased binding to Transportin and distinguish FTLD-FUS from ALS-FUS. Acta neuropathologica, 131(4), pp. 587-604. Springer 10.1007/s00401-016-1544-2
Acta neuropathologica 131(4), 587-604 (2016). doi:10.1007/s00401-016-1544-2
Acta neuropathologica 131(4), 587-604 (2016). doi:10.1007/s00401-016-1544-2
Deposition of the nuclear DNA/RNA-binding protein Fused in sarcoma (FUS) in cytosolic inclusions is a common hallmark of some cases of frontotemporal lobar degeneration (FTLD-FUS) and amyotrophic lateral sclero- sis (ALS-FUS). Whether both diseases a
Autor:
Hannelore, Hartmann
Publikováno v:
Pflege Zeitschrift. 57(5)