Genetics of ocular melanoma: Insights into genetics, inheritance and testing

Autor: Robert M. Verdijk, Annelies de Klein, Hanneke W. Mensink, Natasha M. van Poppelen, Tolga Bicer, Nicole C. Naus, Emine Kiliҫ, Dion Paridaens, Erwin Brosens, Daniël P. de Bruyn

Publikováno v: International Journal of Molecular Sciences, Vol 22, Iss 336, p 336 (2021)
International Journal of Molecular Sciences

Ocular melanoma consists of posterior uveal melanoma, iris melanoma and conjunctival melanoma. These malignancies derive from melanocytes in the uveal tract or conjunctiva. The genetic profiles of these different entities differ from each other. In u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d3f8f4926f1c4fd1ffa0dc5570bc26
https://doi.org/10.3390/ijms22010336

Genetic Background of Iris Melanomas and Iris Melanocytic Tumors of Uncertain Malignant Potential

Autor: Hanneke W. Mensink, Annelies de Klein, Hardeep Singh Mudhar, Natasha M. van Poppelen, Quincy C. C. van den Bosch, Paul Rundle, Emine Kilic, Robert M. Verdijk, Tom Brands, Ian G. Rennie, Jolanda Vaarwater, Karen Sisley

Publikováno v: Ophthalmology, 125(6), 904-912. Elsevier Inc.

Purpose Uveal melanoma (UM) is the most common primary intraocular malignancy in adults. Iris melanoma comprises 4% to 10% of all UMs and has a lower mortality rate. The genetic changes in iris melanoma are not as well characterized as ciliary body o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8779c0a6b483d1b6cc3e060c3e277b69
https://doi.org/10.1016/j.ophtha.2017.12.022

Aberrant MicroRNA Expression and Its Implications for Uveal Melanoma Metastasis

Autor: Hanneke W. Mensink, Jolanda Vaarwater, Annelies de Klein, Erik A.C. Wiemer, Robert M. Verdijk, Kyra N Smit, Emine Kilic, Jiang Chang, Tom Brands, Joris Pothof, Kasper W.J. Derks

Publikováno v: Cancers
Volume 11
Issue 6
Cancers, 11(6):E815. Multidisciplinary Digital Publishing Institute (MDPI)
Cancers, Vol 11, Iss 6, p 815 (2019)

Uveal melanoma (UM) is the most frequently found primary intra-ocular tumor in adults. It is a highly aggressive cancer that causes metastasis-related mortality in up to half of the patients. Many independent studies have reported somatic genetic cha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640dc742bd684ee94d508c4b37bdbc95
https://doi.org/10.3390/cancers11060815

Adjuvant Dendritic Cell Vaccination in High-Risk Uveal Melanoma

Autor: Carl G. Figdor, Nicole C. Naus, Sandra Croockewit, Michelle M. van Rossum, Winald R. Gerritsen, Annelies de Klein, Gerty Schreibelt, Cornelis J. A. Punt, Harm Westdorp, Winette T. A. van der Graaf, Wouter J. Japing, Victoria M L Cohen, Kalijn F. Bol, Dion Paridaens, Anna L. de Goede, Jan E.E. Keunen, Thomas van den Bosch, Hanneke W. Mensink, I. Jolanda M. de Vries, Kaspar W. Geul, Emine Kilic, Steve Boudewijns

Publikováno v: Ophthalmology, 123, 10, pp. 2265-7
EUR Research Portal
Ophthalmology, 123(10), 2265-2267. ELSEVIER SCIENCE INC
Ophthalmology, 123(10), 2265-2267. Elsevier Inc.
Ophthalmology, 123(10), 2265-+. Elsevier Inc.
Ophthalmology, 123, 2265-7

Uveal melanoma (UM) is the most common primary intraocular malignancy in adults with an annual incidence of 4 to 10 per million in the white population. The 5-year overall survival (OS) rate is approximately 70% to 80%. Up to 50% of patients with UM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79de14688427e913e10ce71b1b5b818
https://hdl.handle.net/2066/167973

Chromosome 3 Intratumor Heterogeneity in Uveal Melanoma

Autor: Hanneke W. Mensink, Emine Kilic, Neeltje Mooy, Gre P. M. Luyten, Dion Paridaens, Jolanda Vaarwater, Hennie T. Brüggenwirth, Annelies de Klein, Nicole C. Naus

Publikováno v: Investigative Ophthalmology & Visual Science, 50(2), 500-504. Association for Research in Vision and Ophthalmology Inc.

PURPOSE. To investigate the presence of focal or diffuse heterogeneity of monosomy 3 in uveal melanoma, by using fluorescence in situ hybridization (FISH). METHODS. Direct interphase FISH in a series of 151 uveal melanomas revealed 82 tumors with los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db6a9bfe9b2cdf11444974839cbf7cd
https://doi.org/10.1167/iovs.08-2279