Hit hard and early: analysing the effects of high-dose methylprednisolone on nailfold capillary changes and biomarkers in very early systemic sclerosis: study protocol for a 12-week randomised controlled trial

Autor: Wieneke M. T. van den Hombergh, Brigit E. Kersten, Hanneke K. A. Knaapen-Hans, Rogier M. Thurlings, Peter M. van der Kraan, Frank H. J. van den Hoogen, Jaap Fransen, Madelon C. Vonk

Publikováno v: Trials, Vol 19, Iss 1, Pp 1-6 (2018)

Abstract Background Mounting evidence indicates that inflammatory mechanisms drive systemic sclerosis (SSc) vasculopathy and fibrosis, especially early in the disease. Therefore, patients with very early SSc could benefit from early treatments target

Externí odkaz: https://doaj.org/article/cd5efa835f0d48b0afa128f57869c572

SAT0282 EFFICACY AND SAFETY OF ORAL PROSTACYCLIN RECEPTOR AGONIST SELEXIPAG IN PATIENTS WITH SYSTEMIC SCLEROSIS -ASSOCIATED PULMONARY ARTERIAL HYPERTENSIONIN DAILY CLINICAL PRACTICE, A CASE SERIES

Autor: Jolanda van Haren-Willems, C.H.M. van den Ende, Madelon C. Vonk, Anna-Maria Hoffmann-Vold, Toon Duijnhouwer, Jacqueline Mj Lemmers, Frank J. A. van den Hoogen, Håvard Fretheim, Arie P.J. van Dijk, Hanneke K. A. Knaapen-Hans

Publikováno v: Saturday, 15 June 2019.

Background Pulmonary arterial hypertension (PAH) is a frequent complication in systemic sclerosis (SSc) and a major cause of death despite the available treatments (1). Until the availability of the oral prostacyclin receptor agonist selexipag in 201

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0ec519435f822197b5fdcb14c49f1c54
https://doi.org/10.1136/annrheumdis-2019-eular.3021

Survival and organ involvement in patients with limited cutaneous systemic sclerosis and anti-topoisomerase-I antibodies: determined by skin subtype or auto-antibody subtype? A long-term follow-up study

Autor: Hanneke K. A. Knaapen-Hans, Madelon C. Vonk, Frank H J van den Hoogen, Pim Kranenburg, Jaap Fransen, Wieneke M. T. van den Hombergh

Publikováno v: Rheumatology, 55, 11, pp. 2001-2008
Rheumatology, 55, 2001-2008

Contains fulltext : 171578.pdf (Publisher’s version ) (Closed access) OBJECTIVE: LcSSc is associated with ACAs and a mild course, whereas dcSSc is associated with anti-topoisomerase antibodies (ATAs) and a more severe course. However, ATAs are also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7a7f18f9a1b7dde315aa7e34d67e7f1
https://doi.org/10.1093/rheumatology/kew298

AB0651 The effect of cyclophosphamide on pulmonary function and dependence on disease activity of interstitial lung disease associated with systemic sclerosis

Autor: S. O. Simons, Hanneke K. A. Knaapen, J. Fransen, W. Van Den Hombergh, F.H.J. van den Hoogen, Madelon C. Vonk

Publikováno v: Abstracts Accepted for Publication.

Background The pathogenesis of interstitial lung disease associated with systemic sclerosis (SSc-ILD) is not completely elucidated, although it is believed that chronic alveolar inflammation leads to increasing fibrosis. Treatment strategies using cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::06eb4b7a22fb2356ead55815871755b6
https://doi.org/10.1136/annrheumdis-2017-eular.3441

Use of Mycophenolate Mofetil in Patients with Severe Localized Scleroderma Resistant or Intolerant to Methotrexate

Autor: Hanneke K. A. Knaapen, Jorre S. Mertens, Timothy R D J Radstake, Esther P A H Hoppenreijs, Peter C.M. van de Kerkhof, Diane Marsman, Elke M G J de Jong, Marieke M B Seyger

Publikováno v: Acta Dermato-Venereologica, 96, 4, pp. 510-3
Acta Dermato-Venereologica, 96, 510-3
Acta Dermato-Venereologica, 96(4), 510. Society for the Publication of Acta Dermato-Venereologica

Contains fulltext : 168598.pdf (Publisher’s version ) (Open Access) To assess the efficacy and safety of mycophenolate mofetil (MMF) in patients with localized scleroderma (LoS) resistant or intolerant to previous treatment with methotrexate (MTX).

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56620ed9a2030655d41e913ac2c1f70a
https://doi.org/10.2340/00015555-2297