Structure of the integrin receptor αMβ2 headpiece in complex with a function-modulating nanobody

Autor: Hanne Skovsgaard Pedersen, Nick S. Laursen, Gregers R. Andersen, Lorentzen J, Thomas Vorup-Jensen, Rasmus K. Jensen

The integrin receptor αMβ2 mediates phagocytosis of complement-opsonized objects, adhesion to the extracellular matrix and trans-endothelial migration of leukocytes. Here we present the first atomic structure of the human αMβ2 headpiece fragment

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca9318ea616607d3a90686228971fbc
https://doi.org/10.1101/2021.07.07.451531

In vivo Evidence That SORL1, Encoding the Endosomal Recycling Receptor SORLA, Can Function as a Causal Gene in Alzheimer's Disease

Autor: Giulia Monti, Lars Friis Mikkelsen, Marianne Lundsgaard Kristensen, Kirsten R Jacobsen, Charlotte E. Teunissen, David J. Brooks, Lars Bolund, Anne M. Landau, Christoffer Laustsen, Scott A. Small, Yonglun Luo, Anne Mette G. Jensen, Laura Breidenbach, Gro Grunnet Pløen, Jens R. Nyengaard, Margarita Melnikova Jørgensen, Hanne Skovsgaard Pedersen, Esben Søvsø Szocska Hansen, Charlotte S. Sørensen, Nikolaj Bøgh, Ying Liu, Mathias Droescher, Henrik Callesen, Benedicte Parm Ulhøi, Ida Elisabeth Holm, Olav M. Andersen

Publikováno v: SSRN Electronic Journal.

The few established causal genes in Alzheimer’s disease (AD), mutations in APP and PSENs, have been functionally characterized using biomarkers, capturing an in vivo profile reflecting the disease’s initial preclinical phase. SORL1, a gene encodi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c889777cc95690fcd8e7edfc98005a51
https://doi.org/10.2139/ssrn.3911555

Characterization of the endometrial transcriptome in early diestrus influencing pregnancy status in dairy cattle after transfer of in vitro-produced embryos

Autor: Maria B Rabaglino, Poul Hyttel, Haja N. Kadarmideen, Gianluca Mazzoni, Hanne Skovsgaard Pedersen, Henrik Callesen

Publikováno v: Mazzoni, G, Pedersen, H S, Rabaglino, M B, Hyttel, P, Callesen, H & Kadarmideen, H N 2020, ' Characterization of the endometrial transcriptome in early diestrus influencing pregnancy status in dairy cattle after transfer of in vitro-produced embryos ', Physiological Genomics, vol. 52, no. 7, pp. 269-279 . https://doi.org/10.1152/physiolgenomics.00027.2020
Mazzoni, G, Pedersen, H S, Rabaglino, M B, Hyttel, P, Callesen, H & Kadarmideen, H N 2020, ' Characterization of the endometrial transcriptome in early diestrus influencing pregnancy status in dairy cattle after transfer of in-vitro produced embryos ', Physiological Genomics, vol. 52, no. 7, pp. 269-279 . https://doi.org/10.1152/physiolgenomics.00027.2020

Modifications of the endometrial transcriptome at day 7 of the estrus cycle are crucial to maintain gestation after transfer of in vitro-produced (IVP) embryos, although these changes are still largely unknown. The aim of this study was to identify g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c000c78f47e6edb92977c44a16335f0d
https://curis.ku.dk/portal/da/publications/characterization-of-the-endometrial-transcriptome-in-early-diestrus-influencing-pregnancy-status-in-dairy-cattle-after-transfer-of-in-vitroproduced-embryos(a2ffc7e2-9002-4f73-b258-02636bb45a0c).html

Effect of cumulus cells and sperm concentration on fertilization and development of pig oocytes

Autor: Rong Li, Henrik Callesen, Ying Liu, Hanne Skovsgaard Pedersen

Publikováno v: Li, R, Liu, Y, Pedersen, H S & Callesen, H 2018, ' Effect of cumulus cells and sperm concentration on fertilization and development of pig oocytes ', Reproduction in Domestic Animals, vol. 53, pp. 1009-1012 . https://doi.org/10.1111/rda.13184

In pigs, in vitro fertilization (IVF) is still hampered by low blastocyst rates, first of all due to a high rate of polyspermy. The many attempts made to reduce this problem have often compromised penetration and fertilization rates, not improving ov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f4ece84f8e122442ed1c957df80e46f
https://doi.org/10.1111/rda.13184

Combined in vitro fertilization and culture (IVF/IVC) in mouse for reprotoxicity assessment of xenobiotic exposure

Autor: Martin Tang Sørensen, Knud Larsen, Hanne Skovsgaard Pedersen, Kaja Kjær Kristensen, Ying Liu, Henrik Callesen, Leslie Foldager

Publikováno v: Liu, Y, Pedersen, H S, Larsen, K E, Kristensen, K, Foldager, L, Callesen, H & Sørensen, M T 2019, ' Combined in vitro fertilization and culture (IVF/IVC) in mouse for reprotoxicity assessment of xenobiotic exposure ', Reproductive Toxicology, vol. 89, no. October, pp. 115-123 . https://doi.org/10.1016/j.reprotox.2019.07.006

Litter size and other conventional measures in rodents are common end-points in the assessment of xenobiotics for reprotoxic effects. However, since litter size may be normal despite reduced semen quality, we established and tested a mouse in vitro f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dc7b0029afeb5bf38aab6c2749319d3
https://pure.au.dk/portal/da/publications/combined-in-vitro-fertilization-and-culture-ivfivc-in-mouse-for-reprotoxicity-assessment-of-xenobiotic-exposure(1d9b0217-c3e7-4006-833a-ed4d41c5b485).html