Plasminogen Activator Inhibitor 1 Protects Fibrosarcoma Cells from Etoposide-Induced Apoptosis through Activation of the PI3K/Akt Cell Survival Pathway

Autor: Maria U. Rømer, Lise Larsen, Hanne Offenberg, Nils Brünner, Ulrik A. Lademann

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 10, Iss 10, Pp 1083-1091 (2008)

High levels of plasminogen activator inhibitor (PAI-1) in tumors are associated with poor prognosis in several cancer types, and the reason for this association is not fully understood. Plasminogen activator inhibitor 1 has been suggested to contribu

Externí odkaz: https://doaj.org/article/c4eafeb360264bca92804b2a7d7c3a11

Long-Term Safety of PEGylated Coagulation Factor VIII in the Immune-Deficient Rowett Nude Rat

Autor: Julie M. Larsen, Kai Chiu Liu, David Bell, Thomas Krogh-Meibom, Emma Moore, Jette Nowak, Nanna Skall Sorensen, Wendela A. Kappers, Caroline E. Rasmussen, Hanne Offenberg

Publikováno v: Journal of Toxicology, Vol 2017 (2017)
Journal of Toxicology

Turoctocog alfa pegol (N8-GP) is a glycoPEGylated human recombinant factor VIII for the treatment of hemophilia A. The safety profile of rFVIII, and polyethylene glycols (PEG) technology, is well-established. Conducting long-term toxicity studies in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca647804adffeb6770394890eb477dd6
https://doi.org/10.1155/2017/8496246

Evaluation of Nonacog Beta Pegol Long-term Safety in the Immune-deficient Rowett Nude Rat (Crl:NIH-Foxn1rnu)

Autor: Hanne Offenberg, Julie M. Larsen, Alison Rowles, Caroline E. Rasmussen, Jette Nowak, Anna L. Bottomley

Publikováno v: Toxicologic pathology. 44(5)

Nonacog beta pegol is a 40-kDa polyethylene glycosylated (PEGylated) human recombinant coagulation factor IX, intended for the treatment of hemophilia B. Human coagulation factors are immunogenic in animals; therefore, to evaluate the long-term toxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f620d045935ff8f3583ef7f9af477e66
https://pubmed.ncbi.nlm.nih.gov/26940713

Pathology, Tissue Metalloproteinase Transcription and Haptoglobin Responses in Mice after Experimental Challenge with Different Isolates of Pasteurella multocida Obtained from Cases of Porcine Pneumonia

Autor: Dorte Bratbo Sørensen, Hanne Offenberg, Magne Bisgaard, Peter M. H. Heegaard, Susanne Elisabeth Pors, Henrik Jeldtoft Jensen, M. S. Chadfield

Publikováno v: Journal of Comparative Pathology. 145:251-260

Summary Pasteurella multocida is a major cause of porcine pneumonia, but the pathogenesis of the disease is poorly defined. The aim of this study was to further understand the host response to infection by use of a mouse model of P. multocida pneumon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f97798b4d1b46e59d94c339ac784d3
https://doi.org/10.1016/j.jcpa.2011.01.002

Identifying sources and estimating glandular output of salivary TIMP‐1

Autor: Lars Holten-Andersen, S Beier Jensen, Ulrik Lademann, Birgitte Nauntofte, Peter Højrup, Jakob Harslund, Nils Brünner, Hans Jørgen Nielsen, Morten Thaysen-Andersen, Allan Bardow, P. Autzen Usher, Hanne Offenberg, Jesper Reibel

Publikováno v: Holten-Andersen, L, Beier Jensen, S, Bardow, A, Harslund, J, Thaysen-Andersen, M, Lademann, U, Autzen Usher, P, Offenberg, H, Højrup, P, Reibel, J, Nielsen, H J, Brunner, N & Nauntofte, B 2008, ' Identifying sources and estimating glandular output of salivary TIMP-1 ', Scandinavian Journal of Clinical and Laboratory Investigation. Supplement, vol. 68, no. 7, pp. 548-554 . https://doi.org/10.1080/00365510701883180

Objective. Tissue inhibitor of metalloproteinases 1 (TIMP-1) has been identified as a potential biomarker in diseases such as cancer, cardiovascular diseases and diabetes. Since TIMP-1 resides in most tissues and bodily fluids, we evaluated the poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad24513147c3e403802c3e8f85c0f128
https://doi.org/10.1080/00365510701883180