Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Hanne M. Hoffmann"'
Autor:
Brooke M. Van Loh, Alexandra M. Yaw, Joseph A. Breuer, Brooke Jackson, Duong Nguyen, Krystal Jang, Fabiola Ramos, Emily V. Ho, Laura J. Cui, Dominique L. M. Gillette, Lorenzo F. Sempere, Michael R. Gorman, Karen J. Tonsfeldt, Pamela L. Mellon, Hanne M. Hoffmann
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
BackgroundThe suprachiasmatic nucleus (SCN) within the hypothalamus is a key brain structure required to relay light information to the body and synchronize cell and tissue level rhythms and hormone release. Specific subpopulations of SCN neurons, de
Externí odkaz:
https://doaj.org/article/fe803c0e29b2466a93a3c13294295d69
Autor:
Mike R. Wilson, Hilary Skalski, Jake J. Reske, Marc Wegener, Marie Adams, Galen Hostetter, Hanne M. Hoffmann, Jamie J. Bernard, Victoria L. Bae-Jump, Jose M. Teixeira, Ronald L. Chandler
Publikováno v:
Reproductive Biology and Endocrinology, Vol 20, Iss 1, Pp 1-20 (2022)
Abstract Obesity impacts fertility and is positively correlated with endometrial hyperplasia and endometrial cancer occurrence. Endometrial epithelia often harbor disease driver-mutations, while endometrial stroma are highly regulative of neighboring
Externí odkaz:
https://doaj.org/article/9315520ec7494ec88d336252345b051d
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Pre-eclampsia (PE) is a hypertensive condition that occurs during pregnancy and complicates up to 4% of pregnancies. PE exhibits several circadian-related characteristics, and the placenta possesses a functioning molecular clock. We examined
Externí odkaz:
https://doaj.org/article/5b8cd19338ca437fbd75e65ab4b3a633
Autor:
Guoli Zhou, Raina N. Fichorova, Claudia Holzman, Bin Chen, Chi Chang, Eric P. Kasten, Hanne M. Hoffmann
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Long non-coding RNAs (lncRNAs) have a much higher cell- and/or tissue-specificity compared to mRNAs in most cases, making them excellent candidates for therapeutic applications to reduce off-target effects. Placental long non-coding RNAs have been in
Externí odkaz:
https://doaj.org/article/eb40f422006b4e64a5b0a928abfd464a
Autor:
Jason D. Meadows, Joseph A. Breuer, Shanna N. Lavalle, Michael R. Hirschenberger, Meera M. Patel, Duong Nguyen, Alyssa Kim, Jessica Cassin, Michael R. Gorman, David K. Welsh, Pamela L. Mellon, Hanne M. Hoffmann
Publikováno v:
Molecular Metabolism, Vol 57, Iss , Pp 101431- (2022)
Objective: The increasing prevalence of obesity makes it important to increase the understanding of the maturation and function of the neuronal integrators and regulators of metabolic function. Methods: Behavioral, molecular, and physiological analys
Externí odkaz:
https://doaj.org/article/600c4c304fde4903a956dadec4508da6
Autor:
Huimin Xie, Hanne M. Hoffmann, Anita K. Iyer, Melissa J. Brayman, Cindy Ngo, Mary Jean Sunshine, Pamela L. Mellon
Publikováno v:
Reproductive Biology and Endocrinology, Vol 15, Iss 1, Pp 1-11 (2017)
Abstract Background Proper expression of key reproductive hormones from gonadotrope cells of the pituitary is required for pubertal onset and reproduction. To further our understanding of the molecular events taking place during embryonic development
Externí odkaz:
https://doaj.org/article/561860d91a1a47f494c318fe109167e5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 1, p 324 (2020)
Shiftwork, including work that takes place at night (nightshift) and/or rotates between day and nightshifts, plays an important role in our society, but is associated with decreased health, including reproductive dysfunction. One key factor in shiftw
Externí odkaz:
https://doaj.org/article/2fd99dd4851945b987630ffffe06b434
Autor:
Sambit Roy, Aierken Abudu, Irving Salinas, Niharika Sinha, Holly Cline-Fedewa, Alexandra M Yaw, Wenjie Qi, Todd A Lydic, Diana L Takahashi, Jon D Hennebold, Hanne M Hoffmann, Jianrong Wang, Aritro Sen
Publikováno v:
Endocrinology. 163
In women, excess androgen causes polycystic ovary syndrome (PCOS), a common fertility disorder with comorbid metabolic dysfunctions including diabetes, obesity, and nonalcoholic fatty liver disease. Using a PCOS mouse model, this study shows that chr
Autor:
Hanne M. Hoffmann
Publikováno v:
Science. 377:1042-1043
A hormone enhances cognition in mouse models of Alzheimer’s disease and Down syndrome
Publikováno v:
J Neurosci Res
Molecular and behavioral timekeeping is regulated by the circadian system which includes the brain’s suprachiasmatic nucleus (SCN) that translates environmental light information into neuronal and endocrine signals aligning peripheral tissue rhythm