Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Hanne Mørck Nielsen"'
Autor:
Mai Bay Stie, Cristiana Cunha, Zheng Huang, Jacob Judas Kain Kirkensgaard, Pernille Sønderby Tuelung, Feng Wan, Hanne Mørck Nielsen, Vito Foderà, Stine Rønholt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Native mucus is heterogeneous, displays high inter-individual variation and is prone to changes during harvesting and storage. To overcome the lack of reproducibility and availability of native mucus, commercially available purified mucins,
Externí odkaz:
https://doaj.org/article/1b157940f626489fa3f2bfd160346d22
Autor:
Janni Støvring Mortensen, Søren S.-R. Bohr, Lasse Skjoldborg Krog, Johan Peter Bøtker, Vaya Kapousidou, Lasse Saaby, Nikos S. Hatzakis, Hanne Mørck Nielsen, Duc Ninh Nguyen, Stine Rønholt
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The integrity of the intestinal mucus barrier is crucial for human health, as it serves as the body's first line of defense against pathogens. However, postnatal development of the mucus barrier and interactions between maturity and its abil
Externí odkaz:
https://doaj.org/article/51a5f4f8091449cca95c1878c5b87547
Autor:
Anne Weiss, Emilie Delavenne, Carina Matias, Heimo Lagler, Daniel Simon, Ping Li, Jon U. Hansen, Teresa Pires dosSantos, Bimal Jana, Petra Priemel, Christine Bangert, Martin Bauer, Sabine Eberl, Alina Nussbaumer‐Pröll, Zoe Anne Österreicher, Peter Matzneller, Tamara Quint, Maria Weber, Hanne Mørck Nielsen, Thomas Rades, Helle Krogh Johansen, Henrik Westh, Wooseong Kim, Eleftherios Mylonakis, Christian Friis, Luca Guardabassi, John Pace, Carina Vingsbo Lundberg, Fatima M'Zali, Pascal Butty, Nikolaj Sørensen, Henrik Bjørn Nielsen, Rasmus Toft‐Kehler, Emma Guttman‐Yassky, Georg Stingl, Markus Zeitlinger, Morten Sommer
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 5, Pp n/a-n/a (2022)
Abstract Background In patients with atopic dermatitis (AD), Staphylococcus aureus frequently colonizes lesions and is hypothesized to be linked to disease severity and progression. Treatments that reduce S. aureus colonization without significantly
Externí odkaz:
https://doaj.org/article/c12af968bd3a4c4badc928f617fc3d24
Autor:
Miriam E. van Gent, Tom van Baaren, Sylvia N. Kłodzińska, Muhanad Ali, Natasja Dolezal, Bjorn R. van Doodewaerd, Erik Bos, Amy M. de Waal, Roman I. Koning, Jan Wouter Drijfhout, Hanne Mørck Nielsen, Peter H. Nibbering
Publikováno v:
Pharmaceutics, Vol 15, Iss 2, p 429 (2023)
Chronic wound infections colonized by bacteria are becoming more difficult to treat with current antibiotics due to the development of antimicrobial resistance (AMR) as well as biofilm and persister cell formation. Synthetic antibacterial and antibio
Externí odkaz:
https://doaj.org/article/b518551780ec46efb7e3e99e2e77ddab
Autor:
Stine Harloff-Helleberg, Lies A. L. Fliervoet, Mathias Fanø, Mechthild Schmitt, Maxim Antopolski, Arto Urtti, Hanne Mørck Nielsen
Publikováno v:
Drug Delivery, Vol 26, Iss 1, Pp 532-541 (2019)
Oral drug delivery is an attractive noninvasive alternative to injectables. However, oral delivery of biopharmaceuticals is highly challenging due to low stability during transit in the gastrointestinal tract (GIT), resulting in low systemic bioavail
Externí odkaz:
https://doaj.org/article/de17d752cdc448ca8dd3d8f9834ce964
Publikováno v:
Materials & Design, Vol 201, Iss , Pp 109486- (2021)
Additive manufacturing based on direct laser writing two-photon polymerization facilitates the fabrication of microstructures with full 3D design freedom. Here, this fabrication technique is exploited for engineering scaffolds accurately mimicking th
Externí odkaz:
https://doaj.org/article/457570e4c8c2488b962b85cde033c665
Publikováno v:
International Journal of Pharmaceutics: X, Vol 1, Iss , Pp - (2019)
The efficient and reproducible production of nanoparticles using bulk nanoprecipitation methods is still challenging because of low batch to batch reproducibility. Here, we optimize a bulk nanoprecipitation method using design of experiments and tran
Externí odkaz:
https://doaj.org/article/bca42d7a55f640de8cf53167b2355b20
Autor:
Kristin R. Baker, Bimal Jana, Anna Mette Hansen, Hanne Mørck Nielsen, Henrik Franzyk, Luca Guardabassi
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Synthetic peptidomimetics may be designed to mimic functions of antimicrobial peptides, including potentiation of antibiotics, yet possessing improved pharmacological properties. Pairwise screening of 42 synthetic peptidomimetics combined with the an
Externí odkaz:
https://doaj.org/article/8f39c9710bdf471b881d1e0f8d1f3459
Publikováno v:
Pharmaceutics, Vol 12, Iss 10, p 993 (2020)
Oral delivery of therapeutic peptides is hampered by their large molecular size and labile nature, thus limiting their permeation across the intestinal epithelium. Promising approaches to overcome the latter include co-administration with carrier pep
Externí odkaz:
https://doaj.org/article/6b9c20a68dc44310a4511acacfb549fb
Autor:
Jacob Rune Jørgensen, Feiyang Yu, Ramakrishnan Venkatasubramanian, Line Hagner Nielsen, Hanne Mørck Nielsen, Anja Boisen, Thomas Rades, Anette Müllertz
Publikováno v:
Pharmaceutics, Vol 12, Iss 1, p 48 (2020)
Enhancing the oral bioavailability of peptides has received a lot of attention for decades but remains challenging, partly due to low intestinal membrane permeability. Combining a permeation enhancer (PE) with unidirectionally releasing microcontaine
Externí odkaz:
https://doaj.org/article/6113e4f25d064ce4973dc8157ca9b3e1