Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hanne Hoitzing"'
Autor:
Hanne Hoitzing, Payam A Gammage, Lindsey Van Haute, Michal Minczuk, Iain G Johnston, Nick S Jones
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 6, p e1007023 (2019)
The dynamics of the cellular proportion of mutant mtDNA molecules is crucial for mitochondrial diseases. Cellular populations of mitochondria are under homeostatic control, but the details of the control mechanisms involved remain elusive. Here, we u
Externí odkaz:
https://doaj.org/article/28494271e68e473383d5e00dc5b1fce6
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(49)
The expansion of mitochondrial DNA molecules with deletions has been associated with aging, particularly in skeletal muscle fibers; its mechanism has remained unclear for three decades. Previous accounts have assigned a replicative advantage (RA) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5ec1ddec6ab94b0a25a145df2406c14
https://pubmed.ncbi.nlm.nih.gov/36442091
https://pubmed.ncbi.nlm.nih.gov/36442091
The expansion of deleted mitochondrial DNA molecules has been associated with ageing 1,2, particularly in skeletal muscle fibres 3–5; its mechanism has remained unclear for three decades. Previous accounts have assigned a replicative advantage to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa705d9610f189eb41370655a83b2195
https://doi.org/10.1101/2020.09.01.277137
https://doi.org/10.1101/2020.09.01.277137
Publikováno v:
Bioessays
Mitochondria can change their shape from discrete isolated organelles to a large continuous reticulum. The cellular advantages underlying these fused networks are still incompletely understood. In this paper, we describe and compare hypotheses regard
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c8e45274cda9a5bd363aa6a46e35ed
https://doi.org/10.1002/bies.201400188
https://doi.org/10.1002/bies.201400188
Publikováno v:
BioEssays : news and reviews in molecular, cellular and developmental biology. 39(7)
Heterogeneity in mitochondrial content has been previously suggested as a major contributor to cellular noise, with multiple studies indicating its direct involvement in biomedically important cellular phenomena. A recently published dataset explored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c5acab2d551dc1d35af4b40e267af267
https://pubmed.ncbi.nlm.nih.gov/28594445
https://pubmed.ncbi.nlm.nih.gov/28594445
SummaryMitochondrial DNA (mtDNA) copy numbers fluctuate over time due to stochastic cellular dynamics. Understanding mtDNA dynamics and the accumulation of mutations is vital for understanding mitochondrial-related diseases. Here, we use stochastic m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4910eb7f0c4434b3cb26028b04e6847f
https://doi.org/10.1101/145292
https://doi.org/10.1101/145292