Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Hanne Helfrich"'
Autor:
Thorsten Zenz, Wolfgang Huber, Ulrich Keller, Markus Kreuz, Reiner Siebert, Marc Zapatka, Benedikt Brors, Michael Hummel, Lorenz H. Trümper, Markus Löffler, Birgit Burkhardt, Stephan Stilgenbauer, Christiane Pott, Wolfram Klapper, Ralf Küppers, Donato Tedesco, Kyle Bonneau, René Scholtysik, Hanne Helfrich, Olena Yavorska, Marina Lukas, Zhiqin Huang, Rabea Wagener, Sebastian Scheinost, Junyan Lu, Roma Kurilov, Katarzyna Tomska, Stefan Habringer, Alexander Jethwa, Maciej Rosolowski, Mikołaj Słabicki, Jennifer Hüllein
Generanks for differential shRNA effects from GENE-E class comparison analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::141e1098161c68b346a3f1aceaff6fa4
https://doi.org/10.1158/0008-5472.22421259.v1
https://doi.org/10.1158/0008-5472.22421259.v1
Autor:
Thorsten Zenz, Wolfgang Huber, Ulrich Keller, Markus Kreuz, Reiner Siebert, Marc Zapatka, Benedikt Brors, Michael Hummel, Lorenz H. Trümper, Markus Löffler, Birgit Burkhardt, Stephan Stilgenbauer, Christiane Pott, Wolfram Klapper, Ralf Küppers, Donato Tedesco, Kyle Bonneau, René Scholtysik, Hanne Helfrich, Olena Yavorska, Marina Lukas, Zhiqin Huang, Rabea Wagener, Sebastian Scheinost, Junyan Lu, Roma Kurilov, Katarzyna Tomska, Stefan Habringer, Alexander Jethwa, Maciej Rosolowski, Mikołaj Słabicki, Jennifer Hüllein
Generanks for differential shRNA effects from GENE-E class comparison analysis for Achilles Project cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22a332732076accd2c424a5baf573bd0
https://doi.org/10.1158/0008-5472.22421250
https://doi.org/10.1158/0008-5472.22421250
Autor:
Thorsten Zenz, Wolfgang Huber, Ulrich Keller, Markus Kreuz, Reiner Siebert, Marc Zapatka, Benedikt Brors, Michael Hummel, Lorenz H. Trümper, Markus Löffler, Birgit Burkhardt, Stephan Stilgenbauer, Christiane Pott, Wolfram Klapper, Ralf Küppers, Donato Tedesco, Kyle Bonneau, René Scholtysik, Hanne Helfrich, Olena Yavorska, Marina Lukas, Zhiqin Huang, Rabea Wagener, Sebastian Scheinost, Junyan Lu, Roma Kurilov, Katarzyna Tomska, Stefan Habringer, Alexander Jethwa, Maciej Rosolowski, Mikołaj Słabicki, Jennifer Hüllein
Gene expression fold-changes from microarray analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ef77327e6713168615c61f09a93de6
https://doi.org/10.1158/0008-5472.22421253.v1
https://doi.org/10.1158/0008-5472.22421253.v1
Autor:
Thorsten Zenz, Wolfgang Huber, Ulrich Keller, Markus Kreuz, Reiner Siebert, Marc Zapatka, Benedikt Brors, Michael Hummel, Lorenz H. Trümper, Markus Löffler, Birgit Burkhardt, Stephan Stilgenbauer, Christiane Pott, Wolfram Klapper, Ralf Küppers, Donato Tedesco, Kyle Bonneau, René Scholtysik, Hanne Helfrich, Olena Yavorska, Marina Lukas, Zhiqin Huang, Rabea Wagener, Sebastian Scheinost, Junyan Lu, Roma Kurilov, Katarzyna Tomska, Stefan Habringer, Alexander Jethwa, Maciej Rosolowski, Mikołaj Słabicki, Jennifer Hüllein
Table S2. Genetic characterization of BL cell lines; Table S4. Genetic aberrations in aggressive B-NHL patients from the MMML consortium; Table S5. Annotation of TP53 mutation and MDM4 gain in cell lines from the Achilles project; Figure S1. RNAi scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7aaa602c4a67f408a8c3dc3c3e4aa763
https://doi.org/10.1158/0008-5472.22421256
https://doi.org/10.1158/0008-5472.22421256
Autor:
Thorsten Zenz, Wolfgang Huber, Ulrich Keller, Markus Kreuz, Reiner Siebert, Marc Zapatka, Benedikt Brors, Michael Hummel, Lorenz H. Trümper, Markus Löffler, Birgit Burkhardt, Stephan Stilgenbauer, Christiane Pott, Wolfram Klapper, Ralf Küppers, Donato Tedesco, Kyle Bonneau, René Scholtysik, Hanne Helfrich, Olena Yavorska, Marina Lukas, Zhiqin Huang, Rabea Wagener, Sebastian Scheinost, Junyan Lu, Roma Kurilov, Katarzyna Tomska, Stefan Habringer, Alexander Jethwa, Maciej Rosolowski, Mikołaj Słabicki, Jennifer Hüllein
Oncogenic MYC activation promotes proliferation in Burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of Burkitt lymphoma cases. To identify molecular dependencies in Burkitt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::389740a886b81a60a467e3e6a70c2cdc
https://doi.org/10.1158/0008-5472.c.6510870.v1
https://doi.org/10.1158/0008-5472.c.6510870.v1
Autor:
Sebastian Scheinost, Jennifer Hüllein, Benedikt Brors, Markus W. Löffler, Alexander Jethwa, Wolfram Klapper, Hanne Helfrich, Rabea Wagener, Junyan Lu, Stefan Habringer, Ulrich Keller, Kyle Bonneau, Lorenz Trümper, Markus Kreuz, Zhiqin Huang, Stephan Stilgenbauer, Olena Yavorska, Marc Zapatka, Donato Tedesco, Ralf Küppers, Christiane Pott, Maciej Rosolowski, Roma Kurilov, Wolfgang Huber, Thorsten Zenz, René Scholtysik, Mikolaj Slabicki, Michael Hummel, Birgit Burkhardt, Katarzyna Tomska, Marina Lukas, Reiner Siebert
Publikováno v:
Cancer Research. 79:3125-3138
Oncogenic MYC activation promotes proliferation in Burkitt lymphoma, but also induces cell-cycle arrest and apoptosis mediated by p53, a tumor suppressor that is mutated in 40% of Burkitt lymphoma cases. To identify molecular dependencies in Burkitt
Autor:
Peter Møller, Alfred C. Feller, Norbert Schmitz, Hanne Helfrich, Markus Kreuz, Martin-Leo Hansmann, Lorenz Trümper, Andreas Rosenwald, Stephan Stilgenbauer, Harald Stein, Thorsten Zenz, Doris Winter, Maxi Fuge, Annette M. Staiger, Markus Loeffler, Wolfram Klapper, Michael Pfreundschuh, Heike Horn, Reiner Siebert, Jennifer Huellein, German Ott
Publikováno v:
International journal of cancer. 141(7)
TP53 is mutated in 20%-25% of aggressive B-cell lymphoma (B-NHL). To date, no studies have addressed the impact of TP53 mutations in prospective clinical trial cohorts. To evaluate the impact of TP53 mutation to current risk models in aggressive B-NH
Autor:
Thorsten Zenz, Antonio Sarno, Julia Mohr, Maria Heuberger, Patrick Hoth, Hanne Helfrich, Hartmut Döhner, Daniel Mertens, Jennifer Edelmann, Stephan Stilgenbauer
Publikováno v:
Leukemia & Lymphoma. 50:510-513
The importance of studying p53 pathway defects in chronic lymphocytic leukemia (CLL) has been promoted by the demonstration of the fundamentally different clinical course of patients with 17p deletion. The observation of resistance to chemotherapy an
Autor:
Julia Mohr, Hanne Helfrich, Matthias Volden, Hartmut Döhner, Eric Eldering, Maxi Fuge, Arnon P. Kater, Thorsten Zenz, Dirk Winkler, Andreas Bühler, Doreen te Raa, Daniel Mertens, Stephan Stilgenbauer
Publikováno v:
Blood, 117(5), 1622-1632. American Society of Hematology
The DNA damage pathway plays a central role in chemoresistance in chronic lymphocytic leukemia (CLL), as indicated by the prognostic impact of TP53 and ATM loss/mutations. We investigated the function of the p53 axis in primary CLL samples by studyin
Autor:
Nancy Patten, Hanne Helfrich, Jana Šmardová, Andrew R. Pettitt, Patrick Hoth, Rachel E. Ibbotson, Petr Kuglík, Sonja Häbe, Jitka Malčíková, Axel Benner, Jiří Mayer, Tina Denzel, Thorsten Zenz, Maxi Fuge, Lin Wu, Šárka Pospíšilová, Hartmut Döhner, Sim Truong, Stephan Stilgenbauer, Dominik Vollmer, Michael Hallek, Ian Tracy, Maria Heuberger, Anne Gardiner, Martin Trbušek, David Oscier, Thierry Soussi, Ke Lin
Publikováno v:
Leukemia. 24(12)
The TP53 mutation profile in chronic lymphocytic leukemia (CLL) and the correlation of TP53 mutations with allele status or associated molecular genetics are currently unknown. We performed a large mutation analysis of TP53 at four centers and charac