Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

Autor: Arthur Karlin, Hanne Hastrup, Jonathan A. Javitch

Publikováno v: Proceedings of the National Academy of Sciences. 98:10055-10060

There is evidence both for and against Na + - and Cl − -dependent neurotransmitter transporters forming oligomers. We found that cross-linking the human dopamine transporter (DAT), which is heterologously expressed in human embryonic kidney 293 cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f456b41912d489f56e4eceed4a7bf3b
https://doi.org/10.1073/pnas.181344298

ER EXPORT AND SURFACE TARGETING OF THE DOPAMINE TRANSPORTER ARE DEPENDENT ON THE DISTAL C-TERMINUS BUT OCCURS INDEPENDENTLY OF PDZ DOMAIN INTERACTIONS

Autor: Christian Bjerggaard Vægter, Claus Loland, Hanne Hastrup, Kenneth Madsen, Jonathan Javitch, Ulrik Gether

Publikováno v: Bjerggaard(Vægter), C, Loland, C, Hastrup, H, Madsen, K, Javitch, J & Gether, U 2002, ' ER EXPORT AND SURFACE TARGETING OF THE DOPAMINE TRANSPORTER ARE DEPENDENT ON THE DISTAL C-TERMINUS BUT OCCURS INDEPENDENTLY OF PDZ DOMAIN INTERACTIONS ', Society for Neuroscience 32nd annual meeting, Orlando, United States, 02/11/2002-07/11/2002 .
Aarhus University

The human dopamine transporter (hDAT) contains a type 2 C-terminal PDZ binding sequence, Leu-Lys-Val (LKV). It has been suggested that the interaction of this sequence with the "scaffolding" protein PICK1 is critical for surface targeting and presyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::802ee0266bdfae4b357dcf3fdc43a628
https://pure.au.dk/portal/da/publications/er-export-and-surface-targeting-of-the-dopamine-transporter-are-dependent-on-the-distal-cterminus-but-occurs-independently-of-pdz-domain-interactions(fd399970-1c1e-11dd-afca-000ea68e967b).html

Septide and neurokinin A are high-affinity ligands on the NK-1 receptor: evidence from homologous versus heterologous binding analysis

Autor: Thue W. Schwartz, Hanne Hastrup

Publikováno v: FEBS letters. 399(3)

The three main tachykinins, substance P, neurokinin A (NKA), and neurokinin B, are believed to be selective ligands for respectively the NK-1, NK-2 and NK-3 receptors. However, NKA also has actions which cannot be mediated through its normal NK-2 rec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb7f15851a1318a467951eb5e058afe4
https://pubmed.ncbi.nlm.nih.gov/8985159

NK1 receptor fused to beta-arrestin displays a single-component, high-affinity molecular phenotype

Autor: Lene Martini, Hanne Hastrup, Alberto Fraile-Ramos, Thue W. Schwartz, Mark Marsh, Birgitte Holst

Publikováno v: University of Copenhagen

Arrestins are cytosolic proteins that, upon stimulation of seven transmembrane (7TM) receptors, terminate signaling by binding to the receptor, displacing the G protein and targeting the receptor to clathrin-coated pits. Fusion of beta-arrestin1 to t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bceae34eaafbd071e1c7076cce24755e
https://curis.ku.dk/portal/en/publications/nk1-receptor-fused-to-betaarrestin-displays-a-singlecomponent-highaffinity-molecular-phenotype(20eab490-fada-11dd-b219-000ea68e967b).html