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Akademický článek

Fast-acting insulin aspart: a review of its pharmacokinetic and pharmacodynamic properties and the clinical consequences

Autor: Hanne Haahr, Tim Heise

Publikováno v: Сахарный диабет, Vol 23, Iss 2, Pp 140-160 (2020)

Fast-acting insulin aspart (faster aspart) is insulin aspart (IAsp) with two added excipients, L-arginine and niacinamide, to ensure formulation stability with accelerated initial absorption after subcutaneous administration compared with previously

Externí odkaz: https://doaj.org/article/8f6ea16d2b274e568069cac42f9f1865

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Akademický článek

Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing

Autor: Erica Nishimura, Lone Pridal, Tine Glendorf, Bo Falk Hansen, František Hubálek, Thomas Kjeldsen, Niels Rode Kristensen, Anne Lützen, Karsten Lyby, Peter Madsen, Thomas Åskov Pedersen, Rasmus Ribel-Madsen, Carsten Enggaard Stidsen, Hanne Haahr

Publikováno v: BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)

Introduction Insulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties

Externí odkaz: https://doaj.org/article/75bb0be2610749feb0124a6abfc40035

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Commemorating insulin's centennial: engineering insulin pharmacology towards physiology

Autor: Hanne Haahr, Thomas Kjeldsen, Peter Kurtzhals, Peter Madsen, Erica Nishimura, Thomas Hoeg-Jensen, Jeppe Sturis, Eva Johansson

Publikováno v: Trends in Pharmacological Sciences. 42:620-639

The life-saving discovery of insulin in Toronto in 1921 is one of the most impactful achievements in medical history, at the time being hailed as a miracle treatment for diabetes. The insulin molecule itself, however, is poorly amenable as a pharmaco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f64c7f2bacc0f780d68910a496ecfb8d
https://doi.org/10.1016/j.tips.2021.05.005

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216-OR: Hypoglycemia Frequency and Physiological Response to Double or Triple Doses of Once-Weekly Insulin Icodec vs. Once-Daily Insulin Glargine in T2D

Autor: EVA SVEHLIKOVA, KRISTINE NISS ARFELT, ROMAN CAILLETEAU, SIGRID DELLER, KAREN MARGRETE THOMSEN, MARLIES HART, INES MURSIC, THOMAS PIEBER, HANNE HAAHR

Publikováno v: Diabetes. 71

Insulin icodec is a basal insulin in development for once-weekly (OW) dosing. The aim of this study was to compare the hypoglycemia frequency and response after icodec vs. insulin glargine U100 (IGlar) overdosing. In a randomized, open-label, two-per

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cc0c2d22ae49563ae0b0958ac0e1992f
https://doi.org/10.2337/db22-216-or

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The association between anti‐insulin aspart antibodies and the pharmacokinetic and pharmacodynamic characteristics of fast‐acting insulin aspart in children and adolescents with type 1 diabetes

Autor: Line Quist Bendtsen, Hanne Haahr, Mette Dahl Bendtsen, Thekla von dem Berge, Naveen Rathor, Torben Biester, Thomas Danne

Publikováno v: Pediatric Diabetes

Background Fast‐acting insulin aspart (faster aspart) is a novel formulation of insulin aspart (IAsp) ensuring ultrafast absorption and effect. Aim To compare the pharmacokinetics between faster aspart and IAsp, based on free or total IAsp measurem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79365e565bd133170b3fb1012daeb48a
https://doi.org/10.1111/pedi.13026

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Fast‐acting insulin aspart in people with type 2 diabetes: Earlier onset and greater initial exposure and glucose‐lowering effect compared with insulin aspart

Autor: Inge B. Halberg, Hanne Haahr, Thomas R. Pieber, Martina Brunner, Eva Svehlikova, Karen Margrete Due Thomsen

Publikováno v: Diabetes, Obesity & Metabolism

Aims To investigate the pharmacokinetic/pharmacodynamic properties of fast‐acting insulin aspart (faster aspart) versus insulin aspart (IAsp) in people with type 2 diabetes (T2D). Materials and methods In a randomized, double‐blind, crossover des

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77f387fa7e15ff1273a2664a0df7eaac
http://europepmc.org/articles/PMC6771872

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Molecular and pharmacological characterization of insulin icodec: a new basal insulin analog designed for once-weekly dosing

Autor: Hanne Haahr, Carsten Enggaard Stidsen, Rasmus Ribel-Madsen, Anne Lützen, Thomas Åskov Pedersen, Karsten Lyby, Lone Pridal, Thomas Kjeldsen, Peter Madsen, Frantisek Hubalek, Bo Falk Hansen, Erica Nishimura, Niels Rode Kristensen, Tine Glendorf

Publikováno v: BMJ Open Diabetes Research & Care
BMJ Open Diabetes Research & Care, Vol 9, Iss 1 (2021)

IntroductionInsulin icodec is a novel, long-acting insulin analog designed to cover basal insulin requirements with once-weekly subcutaneous administration. Here we describe the molecular engineering and the biological and pharmacological properties

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759dbb38cb97c67986c9ef3b1c415879
https://pubmed.ncbi.nlm.nih.gov/34413118

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