Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Hanne H. F. Refsgaard"'
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Recently, the first orally-administered ultra-long acting insulin was shown to have clinical efficacy. Here, the authors report the molecular engineering, as well as the biological and pharmacological properties of these insulin analogues.
Externí odkaz:
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Frantisek Hubálek, Hanne H. F. Refsgaard, Sanne Gram-Nielsen, Peter Madsen, Erica Nishimura, Martin Münzel, Christian Lehn Brand, Carsten Enggaard Stidsen, Christian Hove Claussen, Erik Max Wulff, Lone Pridal, Ulla Ribel, Jonas Kildegaard, Trine Porsgaard, Eva Johansson, Dorte Bjerre Steensgaard, Lars Hovgaard, Tine Glendorf, Bo Falck Hansen, Maja Kirkegaard Jensen, Peter Kresten Nielsen, Svend Ludvigsen, Susanne Rugh, Patrick W. Garibay, Mary Courtney Moore, Alan D. Cherrington, Thomas Kjeldsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/f3cf07c418ea4af69c46d62c9eb076b7
Autor:
Anna Katrina Jógvansdóttir Gradel, Jens Lykkesfeldt, Hanne H. F. Refsgaard, Jonas Kildegaard, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 128:783-794
In humans, food intake and glucose infusion have been reported to increase subcutaneous blood flow. Since local blood flow influences the rate of insulin absorption from the subcutaneous tissue, we hypothesised that an increase in blood glucose level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cf4719a5d7423fedac194ee0378a443
https://doi.org/10.1111/bcpt.13574
https://doi.org/10.1111/bcpt.13574
Autor:
Erik M. Wulff, Patrick William Garibay, Eva Johansson, Martin Münzel, Tine Glendorf, Erica Nishimura, Bo Falck Hansen, Thomas Kjeldsen, Peter Madsen, Christian L. Brand, Sanne Gram-Nielsen, Trine Porsgaard, Hanne H. F. Refsgaard, Frantisek Hubalek, Svend Ludvigsen, Dorte Bjerre Steensgaard, Lars Hovgaard, Carsten Enggaard Stidsen, Susanne Rugh, Jonas Kildegaard, Lone Pridal, Maja Jensen, Christian Hove Claussen, Ulla Ribel, Alan D. Cherrington, Mary Courtney Moore, Peter Kresten Nielsen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)
Nature Communications
Nature Communications
Recently, the clinical proof of concept for the first ultra-long oral insulin was reported, showing efficacy and safety similar to subcutaneously administered insulin glargine. Here, we report the molecular engineering as well as biological and pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::113155943c2b6a189cde64bb824cd5b9
https://doaj.org/article/b3637544155945e480839f9c67516402
https://doaj.org/article/b3637544155945e480839f9c67516402
Autor:
Johannes Josef Fels, Anne Marie V. Schou-Pedersen, Jonas Kildegaard, Jens Lykkesfeldt, Trine Pagh Ludvigsen, Hanne H. F. Refsgaard, Anna Katrina Jógvansdóttir Gradel, Trine Porsgaard
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 127:278-286
The domestic pig is commonly used as animal model in the pharmaceutical development of new therapeutics for treatment of diabetes. Since a formal definition of hypoglycaemia only exists in humans, the purpose of this study was to assess the counterre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::631b055d4beb0d0756bd0a58239cc19f
https://doi.org/10.1111/bcpt.13422
https://doi.org/10.1111/bcpt.13422
Autor:
Peter Madsen, Thomas Kjeldsen, Claus Bekker Jeppesen, Hanne H. F. Refsgaard, Trine Porsgaard, Helle Naver, Sanne Gram-Nielsen, Frantisek Hubalek, Lone Pridal, Tina Møller Tagmose, Erica Nishimura, Inger Lautrup-Larsen, Carsten Enggaard Stidsen, Valentina Manfè, Thomas Hoeg-Jensen, Claudia Ulrich Hjørringgaard, Svend Ludvigsen, Christian Fledelius
Publikováno v:
Journal of medicinal chemistry. 64(13)
Here, we describe the molecular engineering of insulin icodec to achieve a plasma half-life of 196 h in humans, suitable for once-weekly subcutaneously administration. Insulin icodec is based on re-engineering of the ultra-long oral basal insulin OI3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09bbecdf553cdca0c9ff44818b4017bb
https://pubmed.ncbi.nlm.nih.gov/33944562
https://pubmed.ncbi.nlm.nih.gov/33944562
Autor:
Ulla Ribel, Erik M. Wulff, Alan D. Cherrington, Peter Kresten Nielsen, Martin Münzel, Thomas Kjeldsen, Svend Ludvigsen, Frantisek Hubalek, Lars Hovgaard, Christian Hove Claussen, Jonas Kildegaard, Maja Jensen, Lone Pridal, Hanne H. F. Refsgaard, Patrick William Garibay, Mary Courtney Moore, Sanne Gram-Nielsen, Erica Nishimura, Dorte Bjerre Steensgaard, Carsten Enggaard Stidsen, Tine Glendorf, Peter Madsen, Susanne Rugh, Bo Falck Hansen, Eva Johansson, Christian L. Brand, Trine Porsgaard
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6582242c3083f360c87f02dd8695f95
http://europepmc.org/articles/PMC7441397
http://europepmc.org/articles/PMC7441397
Autor:
Hanne H. F. Refsgaard, Stephen T. Buckley, Jeppe Sturis, Svend Ludvigsen, Torben Seested, Susanne Hostrup, Ulla Ribel, Niels Rode Kristensen, Helle Birk Olsen, Claus Bekker Jeppesen, Rasmus H. Nielsen, Jonas Kildegaard, Gro Klitgaard Povlsen, Kristian Moss Bendtsen
Publikováno v:
Pharmaceutical Research
Purpose Fast-acting insulin aspart (faster aspart) is a novel formulation of insulin aspart containing two additional excipients: niacinamide, to increase early absorption, and L-arginine, to optimize stability. The aim of this study was to evaluate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ace3f066fd74dc055e078a08df6d8365
http://europepmc.org/articles/PMC6373292
http://europepmc.org/articles/PMC6373292
Autor:
Jon R. Hastings, Hanne H. F. Refsgaard, Thomas Kjeldsen, Marta S. Smith, Christian L. Brand, Peter Madsen, Sanne Gram-Nielsen, Phillip E. Williams, Mary Courtney Moore, Ben Farmer, L. Merkle Moore, Erica Nishimura, Alan D. Cherrington, Karsten Wassermann
Publikováno v:
Diabetes. 67
Oral insulin avoids the need for injections, and insulin enters via the hepatic portal vein (Po), the normal route of secretion. We examined the effect of I338, an acylated analog designed for oral use, dosed either Po to match the oral absorption pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::580dcbc6c9bd1143d2b5dc9be8161593
https://doi.org/10.2337/db18-347-or
https://doi.org/10.2337/db18-347-or
Autor:
Hanne H. F. Refsgaard, Christian Vind, Per B. Brockhoff, Berith F. Jensen, Søren Berg Padkjær
Publikováno v:
Journal of Medicinal Chemistry. 50:501-511
Inhibition of cytochrome P450 (CYP) enzymes is unwanted because of the risk of severe side effects due to drug-drug interactions. We present two in silico Gaussian kernel weighted k-nearest neighbor models based on extended connectivity fingerprints
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3ee3e15a65a0d000937927db466b097
https://doi.org/10.1021/jm060333s
https://doi.org/10.1021/jm060333s