Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Hanne C Gadeberg"'
Autor:
Hanne C Gadeberg, Richard C Bond, Cherrie H T Kong, Guillaume P Chanoit, Raimondo Ascione, Mark B Cannell, Andrew F James
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156862 (2016)
BACKGROUND:T-tubules are invaginations of the sarcolemma that play a key role in excitation-contraction coupling in mammalian cardiac myocytes. Although t-tubules were generally considered to be effectively absent in atrial myocytes, recent studies o
Externí odkaz:
https://doaj.org/article/05e15242b8ac42268cd5f465f4792dbd
Autor:
Simon M. Bryant, Hongwei Cheng, Jules C. Hancox, Andrew F. James, Rachel E. Caves, Hanne C. Gadeberg, Stéphanie C.M. Choisy
Publikováno v:
Caves, R E, Cheng, H, Choisy, S C, Gadeberg, H C, Bryant, S M, Hancox, J C & James, A F 2017, ' Atrial-ventricular differences in rabbit cardiac voltage-gated Na + currents: Basis for atrial-selective block by ranolazine ', Heart Rhythm . https://doi.org/10.1016/j.hrthm.2017.06.012
Caves, R, Cheng, H, Choisy, S, Gadeberg, H, Bryant, S, Hancox, J & James, A 2017, ' Atrial-ventricular differences in rabbit cardiac voltage-gated Na + currents : basis for atrial-selective block by ranolazine ', Heart Rhythm, vol. 14, no. 11, pp. 1657-1664 . https://doi.org/10.1016/j.hrthm.2017.06.012
Heart Rhythm
Caves, R, Cheng, H, Choisy, S, Gadeberg, H, Bryant, S, Hancox, J & James, A 2017, ' Atrial-ventricular differences in rabbit cardiac voltage-gated Na + currents : basis for atrial-selective block by ranolazine ', Heart Rhythm, vol. 14, no. 11, pp. 1657-1664 . https://doi.org/10.1016/j.hrthm.2017.06.012
Heart Rhythm
BACKGROUND Class 1 antiarrhythmic drugs are highly effective in restoring and maintaining sinus rhythm in atrial fibrillation patients but carry a risk of ventricular tachyarrhythmia. The anti-anginal agent, ranolazine, is a prototypic atrial-selecti
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 313:H190-H199
The balance of Ca2+ influx and efflux regulates the Ca2+ load of cardiac myocytes, a process known as autoregulation. Previous work has shown that Ca2+ influx, via L-type Ca2+ current ( ICa), and efflux, via the Na+/Ca2+ exchanger (NCX), occur predom
Autor:
Simon M, Bryant, Cherrie H T, Kong, Judy J, Watson, Hanne C, Gadeberg, David M, Roth, Hemal H, Patel, Mark B, Cannell, Andrew F, James, Clive H, Orchard
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted, and excitation-contraction c
Autor:
Simon M, Bryant, Cherrie H T, Kong, Judy J, Watson, Hanne C, Gadeberg, Andrew F, James, Mark B, Cannell, Clive H, Orchard
Publikováno v:
Experimental Physiology
New Findings What is the central question of this study? Heart failure is associated with redistribution of L‐type Ca2+ current (I Ca) away from the t‐tubule membrane to the surface membrane of cardiac ventricular myocytes. However, the underlyin
Autor:
Cherrie H T, Kong, Simon M, Bryant, Judy J, Watson, Hanne C, Gadeberg, David M, Roth, Hemal H, Patel, Mark B, Cannell, Clive H, Orchard, Andrew F, James
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Aging is associated with diminished cardiac function in males. Cardiac excitation-contraction coupling in ventricular myocytes involves Ca influx via the Ca current (ICa) and Ca release from the sarcoplasmic reticulum, which occur predominantly at t-
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology
This study shows that in contrast to the rat, mouse ventricular Na+/Ca2+ exchange current density is lower in the t-tubules than in the surface sarcolemma and Ca2+ current is predominantly located in the t-tubules. As a consequence, the t-tubules pla
Publikováno v:
Biochemical and Biophysical Research Communications. 408:12-17
The role in the heart of the cardiac isoform of the cystic fibrosis transmembrane conductance regulator (CFTR), which underlies a protein kinase A-dependent Cl(-) current (I(Cl.PKA)) in cardiomyocytes, remains unclear. The identification of a CFTR-se
Autor:
Simon M. Bryant, Hemal H. Patel, David M. Roth, Judy J. Watson, Hanne C. Gadeberg, Cherrie H. Kong, Andrew F. James, Clive H. Orchard, Mark B. Cannell
Publikováno v:
Biophysical Journal. 114:626a
Autor:
Ruth Mears, William J. Wilkinson, Stuart Hanmer, Stephen P. Brazier, Paul J. Kemp, Vsevolod Telezhkin, Hanne C. Gadeberg, Carsten Theodor Muller, Daniela Riccardi
Publikováno v:
Annals of the New York Academy of Sciences. 1177:112-118
The ability of ion channels to respond to an acute perturbation in oxygen tension is a widespread phenomenon, which encompasses many of the major ion channel families. Integral to the ability of several ion channels to respond to acute hypoxic challe