Vancomycin concentrations in the cervical spine after intravenous administration: results from an experimental pig study

Autor: Mats Bue, Pelle Hanberg, Mikkel Tøttrup, Maja B Thomassen, Hanne Birke-Sørensen, Theis M Thillemann, Torben L Andersson, Kjeld Søballe

Publikováno v: Acta Orthopaedica, Vol 89, Iss 6, Pp 683-688 (2018)

Background and purpose — Vancomycin may be an important drug for intravenous perioperative antimicrobial prophylaxis in spine surgery. We assessed single-dose vancomycin intervertebral disc, vertebral cancellous bone, and subcutaneous adipose tissu

Externí odkaz: https://doaj.org/article/91f7fb94c1374d7182603351d21b0d32

Development of intestinal ischemia/reperfusion-induced acute kidney injury in rats with or without chronic kidney disease: Cytokine/chemokine response and effect of α-melanocyte-stimulating hormone

Autor: Martin Skott, Rikke Nørregaard, Hanne Birke-Sørensen, Johan Palmfeldt, Tae-Hwan Kwon, Thomas Jonassen, Jørgen Frøkiær, Søren Nielsen

Publikováno v: Kidney Research and Clinical Practice, Vol 33, Iss 2, Pp 79-88 (2014)

Background: The primary aim of the study was to investigate the cytokine/chemokine response in the kidney, lung, and liver following acute kidney injury (AKI). The secondary aim was to test whether α-melanocyte-stimulating hormone (α-MSH) could pre

Externí odkaz: https://doaj.org/article/b135554e155442999cbb9edcae4aa32e

Microdialysis for the Assessment of Intervertebral Disc and Vertebral Cancellous Bone Metabolism in a Large Porcine Model

Autor: Kjeld Søballe, Hanne Birke-Sørensen, Mats Bue, Theis Muncholm Thillemann, Pelle Hanberg, Mikkel Tøttrup, Maja B. Thomassen

Publikováno v: Bue, M, Hanberg, P, Thomassen, M B, Tøttrup, M, Thillemann, T M, Søballe, K & Birke-Sørensen, H 2020, ' Microdialysis for the Assessment of Intervertebral Disc and Vertebral Cancellous Bone Metabolism in a Large Porcine Model ', In Vivo, vol. 34, no. 2, pp. 527-532 . https://doi.org/10.21873/invivo.11804

BACKGROUND/AIM: It remains challenging to evaluate the in vivo pathophysiological biochemical characteristics in spine tissue, due to lack of an applicable model and feasible methods. The aim of this study was to apply microdialysis for the assessmen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1859af301996b27811b1a954c53d4225
https://vbn.aau.dk/da/publications/ca30613e-c243-46cc-91a0-4d09ad9c4ac1

Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients - a randomized controlled trial comparing continuous and short-term infusion

Autor: Mats Bue, Kjeld Søballe, Peter Riis Hansen, Mikkel Tøttrup, Kurt Fuursted, Tore Forsingdal Hardlei, Hanne Birke-Sørensen, Bo Martin Bibby

Publikováno v: Tøttrup, M, Søballe, K, Bibby, B M, Hardlei, T F, Hansen, P, Fuursted, K, Birke-Sørensen, H & Bue, M 2019, ' Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients : a randomized controlled trial comparing continuous and short-term infusion ', A P M I S. Acta Pathologica, Microbiologica et Immunologica Scandinavica, vol. 127, no. 12, pp. 779-788 . https://doi.org/10.1111/apm.12996
Tøttrup, M, Søballe, K, Bibby, B M, Hardlei, T F, Hansen, P, Fuursted, K, Birke-Sørensen, H & Bue, M 2019, ' Bone, subcutaneous tissue and plasma pharmacokinetics of cefuroxime in total knee replacement patients-a randomized controlled trial comparing continuous and short-term infusion ', APMIS-Journal of Pathology, Microbiology and Immunology, vol. 127, no. 12, pp. 779-788 . https://doi.org/10.1111/apm.12996

Cefuroxime is widely used as antibiotic prophylaxis for orthopaedic procedures. We evaluated bone, subcutaneous tissue (SCT) and plasma pharmacokinetics of cefuroxime in male patients undergoing total knee replacement (TKR) after both traditional sho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::339eed3d92a5a1efb846f72a351aff8c
https://pubmed.ncbi.nlm.nih.gov/31515843

Single-dose pharmacokinetics of vancomycin in porcine cancellous and cortical bone determined by microdialysis

Autor: Mats Bue, Kjeld Søballe, Hanne Birke-Sørensen, Theis Muncholm Thillemann, Mikkel Tøttrup, Tore Forsingdal Hardlei

Publikováno v: Bue, M, Birke-Sørensen, H, Thillemann, T M, Hardlei, T F, Søballe, K & Tøttrup, M 2015, ' Single-dose pharmacokinetics of vancomycin in porcine cancellous and cortical bone determined by microdialysis ', International Journal of Antimicrobial Agents . https://doi.org/10.1016/j.ijantimicag.2015.06.014

High treatment failure rates and the need for prolonged antimicrobial therapy for osteomyelitis and implant-associated infections suggest that antimicrobial bone penetration may be incomplete. Assessment of the bone pharmacokinetics of antimicrobials

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20d52ec2a4e42dddae758d9b367d610e
https://doi.org/10.1016/j.ijantimicag.2015.06.014