Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Hanne B Christensen"'
Autor:
Hao Luo, Anne Sofie L Hansen, Lei Yang, Konstantin Schneider, Mette Kristensen, Ulla Christensen, Hanne B Christensen, Bin Du, Emre Özdemir, Adam M Feist, Jay D Keasling, Michael K Jensen, Markus J Herrgård, Bernhard O Palsson
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e2007050 (2019)
We present a selection design that couples S-adenosylmethionine-dependent methylation to growth. We demonstrate its use in improving the enzyme activities of not only N-type and O-type methyltransferases by 2-fold but also an acetyltransferase of ano
Externí odkaz:
https://doaj.org/article/8a014f6bc453477b97b3c4f4f1ca61cc
Autor:
Iben Møller-Hansen, Javier Sáez-Sáez, Steven A. van der Hoek, Jane D. Dyekjær, Hanne B. Christensen, Marina Wright Muelas, Steve O’Hagan, Douglas B. Kell, Irina Borodina
Publikováno v:
Frontiers in Microbiology, Vol 15 (2024)
The exchange of small molecules between the cell and the environment happens through transporter proteins. Besides nutrients and native metabolic products, xenobiotic molecules are also transported, however it is not well understood which transporter
Externí odkaz:
https://doaj.org/article/6f38c4a069ba4bb9bfc92038387920b6
Autor:
Lei Yang, Sailesh Malla, Emre Özdemir, Se Hyeuk Kim, Rebecca Lennen, Hanne B. Christensen, Ulla Christensen, Lachlan J. Munro, Markus J. Herrgård, Douglas B. Kell, Bernhard Ø. Palsson
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
Transporter discovery and engineering play an important role in cell factory development. Decreasing the intracellular concentration of the product reduces product inhibition and/or toxicity. Lowering intracellular concentrations is especially benefi
Externí odkaz:
https://doaj.org/article/a72a6bb98b6a4e3fb6ae94fafcea86da
Autor:
Jie Zhang, Lea G. Hansen, Olga Gudich, Konrad Viehrig, Lærke M. M. Lassen, Lars Schrübbers, Khem B. Adhikari, Paulina Rubaszka, Elena Carrasquer-Alvarez, Ling Chen, Vasil D’Ambrosio, Beata Lehka, Ahmad K. Haidar, Saranya Nallapareddy, Konstantina Giannakou, Marcos Laloux, Dushica Arsovska, Marcus A. K. Jørgensen, Leanne Jade G. Chan, Mette Kristensen, Hanne B. Christensen, Suresh Sudarsan, Emily A. Stander, Edward Baidoo, Christopher J. Petzold, Tune Wulff, Sarah E. O’Connor, Vincent Courdavault, Michael K. Jensen, Jay D. Keasling
Publikováno v:
Nature
Zhang, J, Hansen, L G, Gudich, O, Viehrig, K, Lassen, L M M, Schrübbers, L, Adhikari, K B, Rubaszka, P, Carrasquer-Alvarez, E, Chen, L, D’Ambrosio, V, Lehka, B, Haidar, A K, Nallapareddy, S, Giannakou, K, Laloux, M, Arsovska, D, Jørgensen, M A K, Chan, L J G, Kristensen, M, Christensen, H B, Sudarsan, S, Stander, E A, Baidoo, E, Petzold, C J, Wulff, T, O’Connor, S E, Courdavault, V, Jensen, M K & Keasling, J D 2022, ' A microbial supply chain for production of the anti-cancer drug vinblastine ', Nature, vol. 609, no. 7926, pp. 341-347 . https://doi.org/10.1038/s41586-022-05157-3
Nature, vol 609, iss 7926
Zhang, J, Hansen, L G, Gudich, O, Viehrig, K, Lassen, L M M, Schrübbers, L, Adhikari, K B, Rubaszka, P, Carrasquer-Alvarez, E, Chen, L, D’Ambrosio, V, Lehka, B, Haidar, A K, Nallapareddy, S, Giannakou, K, Laloux, M, Arsovska, D, Jørgensen, M A K, Chan, L J G, Kristensen, M, Christensen, H B, Sudarsan, S, Stander, E A, Baidoo, E, Petzold, C J, Wulff, T, O’Connor, S E, Courdavault, V, Jensen, M K & Keasling, J D 2022, ' A microbial supply chain for production of the anti-cancer drug vinblastine ', Nature, vol. 609, no. 7926, pp. 341-347 . https://doi.org/10.1038/s41586-022-05157-3
Nature, vol 609, iss 7926
Monoterpene indole alkaloids (MIAs) are a diverse family of complex plant secondary metabolites with many medicinal properties, including the essential anti-cancer therapeutics vinblastine and vincristine1. As MIAs are difficult to chemically synthes