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of 10
pro vyhledávání: '"Hannah-Lena Obermann"'
Autor:
Hannah-Lena Obermann, Ines I. Lederbogen, Jenny Steele, Jens Dorna, Leif Erik Sander, Konrad Engelhardt, Udo Bakowsky, Andreas Kaufmann, Stefan Bauer
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
The innate immune system senses viral and bacterial ribonucleic acid (RNA) via pattern recognition receptors (PRR) leading to subsequent activation of the immune system. One group of RNA sensors is formed by endosomal/lysosomal Toll-like receptors (T
Externí odkaz:
https://doaj.org/article/acc91f308ef140a6a72e1c711f91676c
Autor:
Marina Nicolai, Julia Steinberg, Hannah-Lena Obermann, Francisco Venegas Solis, Eva Bartok, Stefan Bauer, Stephanie Jung
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11139 (2022)
Recognition of RNA by receptors of the innate immune system is regulated by various posttranslational modifications. Different single 2′-O-ribose (2′-O-) methylations have been shown to convert TLR7/TLR8 ligands into specific TLR8 ligands, so we
Externí odkaz:
https://doaj.org/article/3beb0d8175c5448180409cff2dfbbae0
Publikováno v:
Immunobiology. 224:843-851
The innate immune system senses viral and bacterial RNA or DNA via different cytoplasmic or endosomal localized pattern recognition receptors. In general, the preference of these receptors for single-stranded (ss), double-stranded (ds) RNA or DNA has
Autor:
Andreas Kaufmann, Sven Zukunft, Hannah-Lena Obermann, Nelli Baal, Alexander Goesmann, Andrea Nist, Oliver Rupp, Gregor Bein, Kristina Dietert, Sarah Cunningham, Thorsten Stiewe, Anne Lippitsch, Gabriela Michel, Jürgen Lohmeyer, Stefan Bauer, Jenny Thomas, Holger Hackstein, Ingrid Fleming, Achim D. Gruber
Publikováno v:
The Journal of Immunology. 202:1099-1111
RNA editing by adenosine deaminases acting on dsRNA (ADAR) has become of increasing medical relevance, particularly because aberrant ADAR1 activity has been associated with autoimmunity and malignancies. However, the role of ADAR1 in dendritic cells
Autor:
Gabriele Köllisch, Francisco Venegas Solis, Hannah-Lena Obermann, Jeannine Eckert, Thomas Müller, Tim Vierbuchen, Thomas Rickmeyer, Simon Muche, Jude M. Przyborski, Holger Heine, Andreas Kaufmann, Stefan Baumeister, Klaus Lingelbach, Stefan Bauer
Publikováno v:
Cell reports. 39(2)
The innate immune recognition of the malaria-causing pathogen Plasmodium falciparum (P. falciparum) is not fully explored. Here, we identify the nucleoside 5ʹ-methylthioinosine (MTI), a Plasmodium-specific intermediate of the purine salvage pathway,
Autor:
Francisco Venegas Solis, Klaus Lingelbach, Thomas Müller, Tim Vierbuchen, Andreas Kaufmann, Holger Heine, Jeannine Eckert, Stefan Baumeister, Hannah-Lena Obermann, Gabriele Köllisch, Stefan Bauer, Simon Muche, Thomas Rickmeyer
Publikováno v:
SSRN Electronic Journal.
The innate immune recognition of the malaria causing pathogen Plasmodium falciparum (Pf) is not yet fully explored. Utilizing genetic complementation assays, Toll-like receptor (TLR)-deficient immune cells, inhibitor studies and molecular modelling,
Autor:
Georgios-Dimitrios Panagiotidis, Harshavardhan Janga, Viktoria Laukemper, Leon N. Schulte, Andreas Schoen, Benjamin Rupf, Andreas Kaufmann, Ines Yang, Marina Nicolai, Stefan Bauer, Friedemann Weber, Stephanie Jung, Tina von Thülen, Hannah-Lena Obermann
Publikováno v:
Nucleic Acids Research
The RNA helicase RIG-I plays a key role in sensing pathogen-derived RNA. Double-stranded RNA structures bearing 5′-tri- or diphosphates are commonly referred to as activating RIG-I ligands. However, endogenous RNA fragments generated during viral i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2a993e3b52562b542e08f68ca95aaa3
https://mediatum.ub.tum.de/1602173
https://mediatum.ub.tum.de/1602173
Autor:
Magdalena, Huber, Tamara, Suprunenko, Thomas, Ashhurst, Felix, Marbach, Hartmann, Raifer, Svenja, Wolff, Thomas, Strecker, Barney, Viengkhou, So Ri, Jung, Hannah-Lena, Obermann, Stefan, Bauer, Haifeng C, Xu, Philipp A, Lang, Adomati, Tom, Karl S, Lang, Nicholas J C, King, Iain L, Campbell, Markus J, Hofer
Publikováno v:
Journal of virology. 91(22)
Effective CD8+ T cell responses play an important role in determining the course of a viral infection. Overwhelming antigen exposure can result in suboptimal CD8+ T cell responses, leading to chronic infection. This altered CD8+ T cell differentiatio
Autor:
Hartmann Raifer, Felix Marbach, Haifeng C. Xu, Hannah-Lena Obermann, Svenja Wolff, Philipp A. Lang, Tamara Suprunenko, Barney Viengkhou, Nicholas J. C. King, Thomas M. Ashhurst, Magdalena Huber, So Ri Jung, Adomati Tom, Karl S. Lang, Stefan Bauer, Iain L. Campbell, Markus J. Hofer, Thomas Strecker
Effective CD8 + T cell responses play an important role in determining the course of a viral infection. Overwhelming antigen exposure can result in suboptimal CD8 + T cell responses, leading to chronic infection. This altered CD8 + T cell differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55b25c47dee9f27c2555b5d2156a405f
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85032289917
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85032289917
Autor:
Stefan Bauer, Hannah-Lena Obermann
Publikováno v:
Immunity. 36(2):159-161
In this issue of Immunity, Silver et al. (2012) provide evidence that murine Toll-like receptor 9 (TLR9) expression and function in innate and adaptive immunity is controlled by the circadian cycle.