Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannah S Coalson"'
Autor:
Margaret AM Nelson, Kelsey L McLaughlin, James T Hagen, Hannah S Coalson, Cameron Schmidt, Miki Kassai, Kimberly A Kew, Joseph M McClung, P Darrell Neufer, Patricia Brophy, Nasreen A Vohra, Darla Liles, Myles C Cabot, Kelsey H Fisher-Wellman
Publikováno v:
eLife, Vol 10 (2021)
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from
Externí odkaz:
https://doaj.org/article/e567853a8a3040149b87851b0c1938d3
Autor:
Ilya N. Boykov, McLane M. Montgomery, James T. Hagen, Raphael T. Aruleba, Kelsey L. McLaughlin, Hannah S. Coalson, Margaret A. Nelson, Andrea S. Pereyra, Jessica M. Ellis, Tonya N. Zeczycki, Nasreen A. Vohra, Su-Fern Tan, Myles C. Cabot, Kelsey H. Fisher-Wellman
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Targeting mitochondrial oxidative phosphorylation (OXPHOS) to treat cancer has been hampered due to serious side-effects potentially arising from the inability to discriminate between non-cancerous and cancerous mitochondria. Herein, compreh
Externí odkaz:
https://doaj.org/article/de226395575a4fb3a7b262bef6cb95d5
Autor:
Kelsey L. McLaughlin, Margaret A.M. Nelson, Hannah S. Coalson, James T. Hagen, McLane M. Montgomery, Ashley R. Wooten, Tonya N. Zeczycki, Nasreen A. Vohra, Kelsey H. Fisher-Wellman
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
Hepatocellular carcinoma (HCC) is the most common form of liver cancer worldwide. Increasing evidence suggests that mitochondria play a central role in malignant metabolic reprogramming in HCC, which may promote disease progression. To comprehensivel
Externí odkaz:
https://doaj.org/article/6b204570f6f945f9909e1b7dce2536ea
Novel approach to quantify mitochondrial content and intrinsic bioenergetic efficiency across organs
Autor:
James T Hagen, Margaret Nelson, Kelsey L. McLaughlin, Kelsey H. Fisher-Wellman, Ashley R. Wooten, Hannah S Coalson, Kimberly A. Kew
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports
Scientific Reports
Human disease pathophysiology commonly involves metabolic disruption at both the cellular and subcellular levels. Isolated mitochondria are a powerful model for separating global cellular changes from intrinsic mitochondrial alterations. However, com
Autor:
Miki Kassai, Su-Fern Tan, Todd E. Fox, Hannah S Coalson, Li-Pin Kao, Kelsey L. McLaughlin, David J. Feith, Margaret Nelson, Mark Kester, Myles C. Cabot, David F. Claxton, Thomas P. Loughran, Kelsey H. Fisher-Wellman, James T Hagen
Publikováno v:
FASEB J
Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in cancer trea
Autor:
Kimberly A. Kew, Darla K. Liles, Joseph M. McClung, P. Darrell Neufer, Patricia Brophy, Cameron A. Schmidt, Hannah S Coalson, Kelsey L. McLaughlin, Kelsey H. Fisher-Wellman, James T Hagen, Myles C. Cabot, Margaret Nelson, Nasreen A. Vohra, Miki Kassai
Publikováno v:
eLife, Vol 10 (2021)
eLife
eLife
Currently there is great interest in targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer. However, notwithstanding the targeting of mutant dehydrogenases, nearly all hopeful ‘mito-therapeutics’ cannot discriminate cancerous from
Autor:
Nasreen A. Vohra, Miki Kassai, Hannah S Coalson, Joseph M. McClung, James T Hagen, Myles C. Cabot, Darla K. Liles, Kimberly A. Kew, Kelsey L. McLaughlin, Margaret Nelson, Patricia Brophy, Kelsey H. Fisher-Wellman, Cameron A. Schmidt, P. Darrell Neufer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8c60d39f774c49fb5252dd355bf33aa9
https://doi.org/10.7554/elife.63104.sa2
https://doi.org/10.7554/elife.63104.sa2
Autor:
James T Hagen, Myles C. Cabot, David F. Claxton, Margaret Nelson, Mark Kester, Thomas P. Loughran, Kelsey H. Fisher-Wellman, Su-Fern Tan, Li-Pin Kao, Miki Kassai, Kelsey L. McLaughlin, David J. Feith, Todd E. Fox, Hannah S Coalson
Background: Modifications in sphingolipid (SL) metabolism and mitochondrial bioenergetics are key factors implicated in cancer cell response to chemotherapy, including chemotherapy resistance. Vinca alkaloids such as vincristine (VCR), widely used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c8fb73cef03826f4865cc911931369f
https://doi.org/10.21203/rs.3.rs-506642/v1
https://doi.org/10.21203/rs.3.rs-506642/v1
Autor:
Ilya Boykov, McLane M. Montgomery, James T. Hagen, Hannah S. Coalson, Kelsey H. Fisher-Wellman
Publikováno v:
Cancer Research. 82:LB126-LB126
Typified by oxidative phosphorylation (OXPHOS), mitochondria catalyze a wide variety of cellular processes now understood to be critical for malignant growth. As such, there is considerable interest in targeting mitochondrial OXPHOS in cancer. The pr
Autor:
Hannah S Coalson, Cameron A. Schmidt, Darla K. Liles, Nasreen A. Vohra, Kelsey H. Fisher-Wellman, P D Neufer, James T Hagen, Patricia Brophy, Kelsey L. McLaughlin, Margaret Nelson, Myles C. Cabot, Kimberly A. Kew, Joseph M. McClung
Currently there is great interest in developing cytotoxic pharmacotherapies that disrupt mitochondrial energy transduction in cancer. Given that mitochondria are critical to mammalian energy homeostasis, clinical success of a given therapeutic will u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f92b2cb5c2023f670e44ead322f482f3
https://doi.org/10.21203/rs.3.rs-64203/v1
https://doi.org/10.21203/rs.3.rs-64203/v1