Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Hannah S, Newton"'
Autor:
Hannah S. Newton, Jenny Zhang, Duncan Donohue, Ragi Unnithan, Edward Cedrone, Jie Xu, Alison Vermilya, Tyler Malys, Jeffrey D. Clogston, Marina A. Dobrovolskaia
Publikováno v:
Frontiers in Allergy, Vol 4 (2023)
IntroductionImmunophenotyping, which is the identification of immune cell subsets based on antigen expression, is an integral technique used to determine changes of cell composition and activation in various disease states or as a response to differe
Externí odkaz:
https://doaj.org/article/bd774b4beec14b8db17cb8ee2017a52b
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 133-143 (2021)
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8+ T cell functions including chemotaxis and tumor infiltration. Adenosin
Externí odkaz:
https://doaj.org/article/93994cde84c24784907ef9ef889ddc9c
Autor:
Hannah S. Newton, Yasmine Radwan, Jie Xu, Jeffrey D. Clogston, Marina A. Dobrovolskaia, Kirill A. Afonin
Publikováno v:
Molecules, Vol 28, Iss 11, p 4484 (2023)
Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimulati
Externí odkaz:
https://doaj.org/article/534ab500d97042b2b738b10d4b85f16f
Autor:
Vaibhavkumar S. Gawali, Ameet A. Chimote, Hannah S. Newton, Manuel G. Feria-Garzón, Martina Chirra, Edith M. Janssen, Trisha M. Wise-Draper, Laura Conforti
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Programmed death receptor-1 (PD-1) and its ligand (PD-L1) interaction negatively regulates T cell function in head and neck squamous cell carcinoma (HNSCC). Overexpression of PD-1 reduces intracellular Ca2+ fluxes, and thereby T cell effector functio
Externí odkaz:
https://doaj.org/article/3988e8398cf542708e8c547c9f888c29
Autor:
Laura Conforti, Edith M Janssen, Hannah S Newton, Vaibhavkumar S Gawali, Ameet A Chimote, Maria A Lehn, Sarah M Palackdharry, Benjamin H Hinrichs, Roman Jandarov, David Hildeman, Trisha M Wise-Draper
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Immunotherapy has emerged as a promising treatment modality for head and neck squamous cell carcinoma (HNSCC). Pembrolizumab, an anti-programmed death 1 antibody, is an immunotherapy agent currently approved for metastatic HNSCC and curati
Externí odkaz:
https://doaj.org/article/65aba8cacdf74f5d84b824a04f706c53
Autor:
Ameet A. Chimote, Vaibhavkumar S. Gawali, Hannah S. Newton, Trisha M. Wise-Draper, Laura Conforti
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
The limited ability of cytotoxic CD8+ T cells to infiltrate solid tumors and function within the tumor microenvironment presents a major roadblock to effective immunotherapy. Ion channels and Ca2+-dependent signaling events control the activity of T
Externí odkaz:
https://doaj.org/article/6de5d9af9a4947339b10f27bd2a1fae0
Autor:
Afonin, Hannah S. Newton, Yasmine Radwan, Jie Xu, Jeffrey D. Clogston, Marina A. Dobrovolskaia, Kirill A.
Publikováno v:
Molecules; Volume 28; Issue 11; Pages: 4484
Nucleic acid nanoparticles (NANPs) require a carrier to allow for their intracellular delivery to immune cells. Cytokine production, specifically type I and III interferons, allows for reliable monitoring of the carrier effect on NANP immunostimulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::a6c6a4ca875ab54b540a7ca40e588d08
Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier
Autor:
Yelixza I. Avila, Morgan Chandler, Edward Cedrone, Hannah S. Newton, Melina Richardson, Jie Xu, Jeffrey D. Clogston, Neill J. Liptrott, Kirill A. Afonin, Marina A. Dobrovolskaia
Publikováno v:
Molecules, Vol 26, Iss 3, p 652 (2021)
Recent insights into the immunostimulatory properties of nucleic acid nanoparticles (NANPs) have demonstrated that variations in the shape, size, and composition lead to distinct patterns in their immunostimulatory properties. While most of these stu
Externí odkaz:
https://doaj.org/article/8f16ade319414daab6b20f4ae0003a4a
Autor:
Martina Chirra, Hannah S. Newton, Vaibhavkumar S. Gawali, Trisha M. Wise-Draper, Ameet A. Chimote, Laura Conforti
Publikováno v:
Cancers. 14(15)
Competent antitumor immune cells are fundamental for tumor surveillance and combating active cancers. Once established, tumors generate a tumor microenvironment (TME) consisting of complex cellular and metabolic elements that serve to suppress the fu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4ac646ce8cc2c7cbea1c72de14c746
https://pubmed.ncbi.nlm.nih.gov/35892822
https://pubmed.ncbi.nlm.nih.gov/35892822
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss, Pp 133-143 (2021)
In solid malignancies, including head and neck squamous cell carcinoma (HNSCC), the immunosuppressive molecule adenosine, which accumulates in the tumor, suppresses cytotoxic CD8+ T cell functions including chemotaxis and tumor infiltration. Adenosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35bd722758f7f0642185642751493dde
https://doi.org/10.1016/j.omtm.2021.03.001
https://doi.org/10.1016/j.omtm.2021.03.001