Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Hannah Pollard"'
Autor:
David I Fisher, Roger L. Williams, Domagoj Baretić, Hannah Pollard, Martina Niess, Christopher M. Johnson, Eileen McCall, Taiana Maia de Oliveira, Christopher R. Phillips, Caroline Truman, Paul Wan
Publikováno v:
Progress in Biophysics and Molecular Biology. 147:4-16
ATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c4491ce2bce8065187c2b220e9a0a55
https://doi.org/10.1016/j.pbiomolbio.2019.06.003
https://doi.org/10.1016/j.pbiomolbio.2019.06.003
Autor:
Huimin Wang, Tony Johnson, Sameer Kawatkar, Peng Wang, Lakshmaiah Gingipalli, Scott D. Edmondson, Jon Read, Scott Boyd, Timothy Ikeda, Andrew Pike, Qibin Su, Olivier Lorthioir, Lianghe Wang, Hannah Dry, Hannah Pollard, Barlaam Bernard Christophe, Haiyun Wang, Scott Boiko
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127523
Hybridisation of amino-pyrimidine based SYK inhibitors (e.g. 1a) with previously reported diamine-based SYK inhibitors (e.g. TAK-659) led to the identification and optimisation of a novel pyrimidine-based series of potent and selective SYK inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b64b2339e860fa1c384ebed0af403608
https://doi.org/10.1016/j.bmcl.2020.127523
https://doi.org/10.1016/j.bmcl.2020.127523
Autor:
James E. Dowling, Scott G. Lamont, Quanshan Wen, Scott Boiko, Peng Wang, Sameer Kawatkar, Scott D. Edmondson, Haiyun Wang, Ujjal Sarkar, Zhiyuan Yan, Barlaam Bernard Christophe, Andrew Pike, Joe Patel, Jon Read, Iain Simpson, Paul D. Kemmitt, Hannah Pollard, Hannah Dry, Timothy Ikeda, Qibin Su, David W. Watson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:127393
Spleen Tyrosine Kinase (SYK) is a well-studied enzyme with therapeutic applications in oncology and autoimmune diseases. We identified an azabenzimidazole (ABI) series of SYK inhibitors by mining activity data of 86,000 compounds from legacy biochemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1114c3d707cb69b964dd0155b8dfbd45
https://doi.org/10.1016/j.bmcl.2020.127393
https://doi.org/10.1016/j.bmcl.2020.127393
Autor:
David I Fisher, Caroline Truman, Alan R. Fersht, Hannah Pollard, Christopher M. Johnson, Tomáš Kouba, Domagoj Baretić, Balaji Santhanam, Christopher R. Phillips, Roger L. Williams
Publikováno v:
Science Advances
Electron cryomicroscopy suggests regulation of ATM by a dynamic equilibrium between open and closed dimers.
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA dam
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase–related protein kinase (PIKK) best known for its role in DNA dam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::019fcde1f42aaae572d5b2a37a04164d
https://doi.org/10.1126/sciadv.1700933
https://doi.org/10.1126/sciadv.1700933
Autor:
James E. Dowling, Michelle Lamb, Erika Krasnickas Keeton, Alexander Hird, Erin Code, Xiaomei Feng, Michael Howard Block, Tina Howard, Les A. Dakin, Huawei Chen, Xiaolan Zheng, Isabelle Green, Paul Lyne, Andrew D. Ferguson, Hannah Pollard, Allan Wu, Jon Read, Tao Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(14)
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-prolif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf7b6241f9d94574ba4d1773e59dab8
https://pubmed.ncbi.nlm.nih.gov/22727640
https://pubmed.ncbi.nlm.nih.gov/22727640
Autor:
Nancy Su, Claudio Chuaqui, Emma L. Cooke, Vicki Racicot, Kumar Thakur, Paul Lyne, Timothy Pontz, Patrick Brassil, Lee John W, Nicholas A. Larsen, James E. Dowling, Allan Wu, Tao Zhang, Qing Ye, Daniel John Russell, Bo Peng, Huawei Chen, Hannah Pollard, Larry Bao, Christopher R. Denz, Michael Howard Block
Publikováno v:
ACS medicinal chemistry letters. 3(4)
In this paper we describe a series of 3-cyano-5-aryl-7-aminopyrazolo[1,5-a]pyrimidine hits identified by kinase-focused subset screening as starting points for the structure-based design of conformationally constrained 6-acetamido-indole inhibitors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfa52ac8e6cd286b6d945581e9ee119
https://pubmed.ncbi.nlm.nih.gov/24900464
https://pubmed.ncbi.nlm.nih.gov/24900464
Autor:
Hai-Jun Zhang, Tina Howard, Isabelle Green, Marat Alimzhanov, Minwei Ye, Michael Howard Block, Hannah Pollard, Ethan Hoffmann, Lynsie Almeida, Mei Su, Stephanos Ioannidis, Michael Zinda, Kirsten Bell, Jon Read, Geraldine Bebernitz, Davies Audrey, Dennis Huszar, Michelle Lamb, Tao Wang, Caroline Rivard, Bo Peng
Publikováno v:
Journal of medicinal chemistry. 54(1)
The myeloproliferative neoplasms, polycythemia vera, essential thrombocythemia, and idiopathic myelofibrosis are a heterogeneous but related group of hematological malignancies characterized by clonal expansion of one or more myeloid lineages. The di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7f5f08188f39c17cf7c191bf5891a78
https://pubmed.ncbi.nlm.nih.gov/21138246
https://pubmed.ncbi.nlm.nih.gov/21138246
Autor:
Xiaolan Zheng, Michael T. Rooney, Michael Howard Block, James E. Dowling, Michelle Lamb, Les A. Dakin, Jon Read, Erika Krasnickas Keeton, Tao Zhang, Paul Lyne, Tina Howard, Allan Wu, Isabelle Green, Erin Code, Xiaomei Feng, Dennis Huszar, Alexander Hird, Andrew D. Ferguson, Hannah Pollard, Huawei Chen
Publikováno v:
Cancer Research. 73:2353-2353
The PIM serine/threonine kinase family, composed of three highly homologous members, PIM-1, PIM-2 and PIM-3, are upregulated in leukemias and lymphomas, including AML, NHL and CLL, highlighting the potential of these kinases as therapeutic targets in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f97a146812a60d5c92ae7dd5af344e2
https://doi.org/10.1158/1538-7445.am2013-2353
https://doi.org/10.1158/1538-7445.am2013-2353
Autor:
Stephanos Ioannidis, Michelle L. Lamb, Tao Wang, Lynsie Almeida, Michael H. Block, Audrey M. Davies, Bo Peng, Mei Su, Hai-Jun Zhang, Ethan Hoffmann, Caroline Rivard, Isabelle Green, Tina Howard, Hannah Pollard, Jon Read, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell, Minwei Ye, Dennis Huszar
Publikováno v:
Journal of Medicinal Chemistry; Jan2011, Vol. 54 Issue 1, p262-276, 15p