Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hannah Piepenbreier"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Antibiotics targeting cell wall synthesis display an unexplained gap between in vivo efficacy and in vitro binding affinity for their target. Here, Piepenbreier et al. develop a model for bacterial cell wall biosynthesis, show how it is affected by a
Externí odkaz:
https://doaj.org/article/a814415456d14601a61c11483ea4c660
Autor:
Hannah Piepenbreier, Andre Sim, Carolin M. Kobras, Jara Radeck, Thorsten Mascher, Susanne Gebhard, Georg Fritz
Publikováno v:
mSystems, Vol 5, Iss 1 (2020)
ABSTRACT Bacterial resistance against antibiotics often involves multiple mechanisms that are interconnected to ensure robust protection. So far, the knowledge about underlying regulatory features of those resistance networks is sparse, since they ca
Externí odkaz:
https://doaj.org/article/bad63c3f2cbc483f965bbdb5448c3e63
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Cell wall antibiotics are crucial for combatting the emerging wave of resistant bacteria. Yet, our understanding of antibiotic action is limited, as many strains devoid of all resistance determinants display far higher antibiotic tolerance in vivo th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09937b519d9aaab0d58b0805fe558d0b
http://link.springer.com/article/10.1038/s41467-019-10673-4
http://link.springer.com/article/10.1038/s41467-019-10673-4
Autor:
Thorsten Mascher, Jara Radeck, Georg Fritz, Hannah Piepenbreier, Andre Sim, Susanne Gebhard, Carolin M. Kobras
Publikováno v:
mSystems
mSystems, Vol 5, Iss 1, p e00687-19 (2020)
Piepenbreier, H, Sim, A, Kobras, C M, Radeck, J, Mascher, T, Gebhard, S & Fritz, G 2020, ' From modules to networks: A systems-level analysis of the bacitracin stress response in Bacillus subtilis ', mSystems, vol. 5, no. 1, e00687-19 . https://doi.org/10.1128/mSystems.00687-19
mSystems, Vol 5, Iss 1 (2020)
mSystems, Vol 5, Iss 1, p e00687-19 (2020)
Piepenbreier, H, Sim, A, Kobras, C M, Radeck, J, Mascher, T, Gebhard, S & Fritz, G 2020, ' From modules to networks: A systems-level analysis of the bacitracin stress response in Bacillus subtilis ', mSystems, vol. 5, no. 1, e00687-19 . https://doi.org/10.1128/mSystems.00687-19
mSystems, Vol 5, Iss 1 (2020)
Antibiotic resistance poses a major threat to global health, and systematic studies to understand the underlying resistance mechanisms are urgently needed. Although significant progress has been made in deciphering the mechanistic basis of individual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff3966a2eb352146841bcfa909921f11
https://pubmed.ncbi.nlm.nih.gov/32019833
https://pubmed.ncbi.nlm.nih.gov/32019833
Publikováno v:
Molecular Microbiology. 104:1-15
Transporters are essential players in bacterial growth and survival, since they are key for uptake of nutrients on the one hand, and for defence against endogenous and environmental stresses on the other hand. Remarkably, in addition to their primary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7ba73a0d6590b4cb1d456630aaacad25
https://doi.org/10.1111/mmi.13633
https://doi.org/10.1111/mmi.13633
Autor:
Georg Fritz, Jennifer Emenegger, Andre Sim, Carolin M. Kobras, Hannah Piepenbreier, Susanne Gebhard
Publikováno v:
Kobras, C M, Piepenbreier, H, Emenegger, J, Sim, A, Fritz, G & Gebhard, S 2020, ' BceAB-type antibiotic resistance transporters appear to act by target protection of cell wall synthesis ', Antimicrobial Agents and Chemotherapy, vol. 64, no. 3, e02241-19 . https://doi.org/10.1128/AAC.02241-19
Antimicrobial Agents and Chemotherapy
Antimicrobial Agents and Chemotherapy
Resistance against cell wall-active antimicrobial peptides in bacteria is often mediated by transporters. In low-GC-content Gram-positive bacteria, a common type of such transporters is BceAB-like systems, which frequently provide high-level resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4a190ae25bcb3789ec8e56ce3ecd2a2
Publikováno v:
Molecular microbiology 111(5), 1367-1381 (2019). doi:10.1111/mmi.14226
Molecular Microbiology
Molecular Microbiology
Summary Heme is an essential cofactor and alternative iron source for almost all bacterial species but may cause severe toxicity upon elevated levels and consequently, regulatory mechanisms coordinating heme homeostasis represent an important fitness
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::983f9cf4ab6be8d79ef68be4c573d02f
https://hdl.handle.net/2128/22383
https://hdl.handle.net/2128/22383