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Data from Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Autor: Joseph W. Landry, David A. Gewirtz, Yves Pommier, William C.K. Pomerantz, Dipankar Bandyopadhyay, Paula D. Bos, Steve E. Kirberger, Xiaoyan Deng, Ryan Finnegan, Joshua Haueis, Syed Haqqani, Manjulata Singh, Ashish Vaidyanathan, Mallika Dammalapati, Hannah Ngo, Nga Dao, Yilun Sun, Liliya Tyutyunyk-Massey

Epigenetic regulators can modulate the effects of cancer therapeutics. To further these observations, we discovered that the bromodomain PHD finger transcription factor subunit (BPTF) of the nucleosome remodeling factor (NURF) promotes resistance to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4bc0c883ceb3539d71fe27c779f70976
https://doi.org/10.1158/1541-7786.c.6545277.v1

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Supplemental Figure 5 from Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Supplemental Figure 5. Selective BPTF Bromdomain Inhibitor AU1 Recapitulates Effects from BPTF KD in Human MDA-MB-231 and Mouse 66cl4 and 4T07 Cell Lines.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eee3dab037824eb4c432997801db05
https://doi.org/10.1158/1541-7786.22526982

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Supplemental Figure 2 from Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Supplemental Figure 2. NURF Selectively Suppresses Toxicity to Topoisomerase 2 Poisons and Improves their DNA Damaging Effects.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14da1f0fee997c059dcc86cd19ec2637
https://doi.org/10.1158/1541-7786.22526991.v1

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Supplemental Figure 4 from Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Supplemental Figure 4. Selective BPTF Bromdomain Inhibitor AU1 Recapitulates Effects from BPTF KD in 4T1 Cells and Tumors.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d8a1ae72d220a7e58c080efeb1f9ccb
https://doi.org/10.1158/1541-7786.22526985

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Supplemental Figure 3 from Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Supplemental Figure 3. Validation of Autophagy by Microscopy and ATG5 KD in 4T1 Cells.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6cea3399c1394e3e7d959a2f370c44
https://doi.org/10.1158/1541-7786.22526988.v1

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Autophagy-Dependent Sensitization of Triple-Negative Breast Cancer Models to Topoisomerase II Poisons by Inhibition of the Nucleosome Remodeling Factor

Autor: Nga Dao, Steve E. Kirberger, Dipankar Bandyopadhyay, Ashish Vaidyanathan, Xiaoyan Deng, Paula D. Bos, Ryan Finnegan, Joshua Haueis, Syed Haqqani, Mallika Dammalapati, Yilun Sun, William C. K. Pomerantz, Yves Pommier, Joseph W. Landry, Hannah Ngo, David A. Gewirtz, Manjulata Singh, Liliya Tyutyunyk-Massey

Publikováno v: Mol Cancer Res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e540ebb55ae683be25df55bbe91fc42
https://pubmed.ncbi.nlm.nih.gov/33811160

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