Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Hannah N. Aldeborgh"'
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
Hyperpolarized MRS of sodium alginate thread cultures. (A) Bright-field image of an alginate thread in culture and (B) H&E stain of the same thread and (C) another cross-section stained with Ki-67. (D) Representative images of an alginate thread cult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57facf18b02cb2b313e40165e8344670
https://doi.org/10.1158/1541-7786.22512912.v1
https://doi.org/10.1158/1541-7786.22512912.v1
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
The PI3K/AKT/mTOR (PAM) signaling pathway is frequently mutated in prostate cancer. Specific AKT inhibitors are now in advanced clinical trials, and this study investigates the effect of MK2206, a non–ATP-competitive inhibitor, on the cellular meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a04805e186470cc6f7431729685fa5b
https://doi.org/10.1158/1541-7786.c.6540375.v1
https://doi.org/10.1158/1541-7786.c.6540375.v1
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
Supp Figure Captions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a14abea208a9d615dfb5509a21401f1
https://doi.org/10.1158/1541-7786.22512930
https://doi.org/10.1158/1541-7786.22512930
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
Western blot of metabolic proteins in LnCAP cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9869ee4bcf095d6af7ad63d3e5c23736
https://doi.org/10.1158/1541-7786.22512924
https://doi.org/10.1158/1541-7786.22512924
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
Co-localization analysis of HKII and CoxIV. LnCAP cells were grown on coverslips, fixed and permeablized for detection of HKII and CoxIV, coupled to Alexa488 and Alexa594 secondary antibodies respectively. Co-localization analysis was performed by th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00695ca1850ac8815d44fe33830f10d0
https://doi.org/10.1158/1541-7786.22512921.v1
https://doi.org/10.1158/1541-7786.22512921.v1
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
LnCAP cells were grown on coverslips, fixed and permeabilized for detection of Glut-1 coupled to Alexa488. Scale bar = 100 μm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bba85ff43f3a7cbcebbf79cc1b1cdd0
https://doi.org/10.1158/1541-7786.22512918.v1
https://doi.org/10.1158/1541-7786.22512918.v1
Autor:
Kayvan R. Keshari, Hannah N. Aldeborgh, Julio A. Alvarez, Valentina DiGialleonardo, Roozbeh Eskandari, Sangmoo Jeong, Steven Truong, Izabela Suster, Sui Seng Tee
Proton NMR spectra of LnCAP cell extracts treated either with DMSO or 1uM MK2206 for 24 hr. Co-factor concentrations were quantified as a ratio between the resonance for the lone hydrogen atom on the five membered ring of the adenine moiety in NAD+ t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41ea0fdc2c2714afb5a6384886afeaa9
https://doi.org/10.1158/1541-7786.22512927
https://doi.org/10.1158/1541-7786.22512927
Autor:
Kayvan R. Keshari, Wolfgang A. Weber, Jason S. Lewis, William D. Tap, Kristin Granlund, Kelly M. Folkers, Vesselin Miloushev, Hannah N. Aldeborgh, Valentina Di Gialleonardo
Supplementary Materials and Methods. Figure S1. Major genetic alterations in of PI3K/AKT/mTOR pathway in 265 sarcoma tumors as summarized by TCGA using cBioPortal. Figure S2. Protein expression level detected with Western blot. Lactate Dehydrogenase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df68363211eb2fd50ff254e40a8b63cc
https://doi.org/10.1158/0008-5472.22412951.v1
https://doi.org/10.1158/0008-5472.22412951.v1
Autor:
Kayvan R. Keshari, Wolfgang A. Weber, Jason S. Lewis, William D. Tap, Kristin Granlund, Kelly M. Folkers, Vesselin Miloushev, Hannah N. Aldeborgh, Valentina Di Gialleonardo
Biomarkers predicting rapalog responses in sarcomas where PI3K and mTOR are often hyperactivated could improve the suitable recruitment of responsive patients to clinical trials. PI3K/mTOR pathway activation drives energy production by regulating ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2537a4bc86787ad67668256531c50f2
https://doi.org/10.1158/0008-5472.c.6508562.v1
https://doi.org/10.1158/0008-5472.c.6508562.v1
Autor:
Julio A. Alvarez, Sui Seng Tee, Valentina DiGialleonardo, Hannah N. Aldeborgh, Steven Truong, Izabela Suster, Sangmoo Jeong, Roozbeh Eskandari, Kayvan R. Keshari
Publikováno v:
Molecular Cancer Research. 16:453-460
The PI3K/AKT/mTOR (PAM) signaling pathway is frequently mutated in prostate cancer. Specific AKT inhibitors are now in advanced clinical trials, and this study investigates the effect of MK2206, a non–ATP-competitive inhibitor, on the cellular meta