Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hannah Murphy-Marshman"'
Autor:
Hannah Murphy-Marshman, Katherine Quensel, Xu Shi-Wen, Rebecca Barnfield, Jacalyn Kelly, Alex Peidl, Richard J Stratton, Andrew Leask
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186740 (2017)
TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), t
Externí odkaz:
https://doaj.org/article/c4ef3a924b5d42ddbbb540787083be69
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0123689 (2015)
Transforming growth factor (TGF)β acts on fibroblasts to promote the production and remodeling of extracellular matrix (ECM). In adult humans, excessive action of TGFβ is associated with fibrotic disease and fibroproliferative conditions, including
Externí odkaz:
https://doaj.org/article/c2af814c928142948a668b6b20598702
Publikováno v:
Rheumatology. 57
Autor:
Katherine Quensel, Xu Shiwen, Andrew Leask, Richard Stratton, Jacalyn Kelly, Hannah Murphy-Marshman, Rebecca Barnfield, Alex Peidl
Publikováno v:
PLoS ONE
PLoS ONE, Vol 12, Iss 10, p e0186740 (2017)
PLoS ONE, Vol 12, Iss 10, p e0186740 (2017)
TGFbeta induces fibrogenic responses in fibroblasts. Reactive oxygen species (ROS)/nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) may contribute to fibrogenic responses. Here, we examine if the antioxidant N-acetylcysteine (NAC), t
Publikováno v:
Journal of Cell Communication and Signaling. 8:59-63
The potent profibrotic cytokine TGFβ induces connective tissue growth factor (CCN2/CTGF) is induced in fibroblasts in a fashion sensitive to SB-431542, a specific pharmacological inhibitor of TGFβ type I receptor (ALK5). In several cell types, TGF
Autor:
Katherine Thompson, Christopher P. Denton, Xu Shiwen, Korsa Khan, Murray Baron, Andrew Leask, David Abraham, Shangxi Liu, Hannah Murphy-Marshman
Publikováno v:
Rheumatology. 51:2146-2154
Fibrotic diseases such as SSc (systemic sclerosis, scleroderma) are characterized by the abnormal presence of the myofibroblast, a specialized type of fibroblast that overexpresses the highly contractile protein α-smooth muscle actin. Myofibroblasts