DISC1 regulates N-Methyl-D-Aspartate receptor dynamics: Abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness

Autor: David J. Porteous, Mostafa Kabiri, Hazel Davidson-Smith, David Price, Marion Bonneau, Daniel L. McCartney, Miles D. Houslay, Paul Perry, J. Kirsty Millar, Kyriakos D. Economides, Shaun Mackie, Laura C. Murphy, Michel Didier, Fumiaki Ogawa, H. Greg Polites, Stephen M. Lawrie, Ellen Grünewald, Barbara Duff, Kathryn L. Evans, Colin A. Semple, Shane T. O’Sullivan, Darragh K. Crummie, Mandy Johnstone, Helen S. Torrance, Jonathan Phillips, Andrew M. McIntosh, Elise L.V. Malavasi, Philippe Gautier, Karen Burr, Costas Constantinides, Susan Anderson, Paraskevi Makedonopoulou, Siddharthan Chandran, Douglas Blackwood, Hannah Murdoch, Matthew Pearson

Publikováno v: Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O'Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational Psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Malavasi, E L V, Economides, K D, Grünewald, E, Makedonopoulou, P, Gautier, P, Mackie, S, Murphy, L C, Murdoch, H, Crummie, D, Ogawa, F, McCartney, D L, O’Sullivan, S T, Burr, K, Torrance, H S, Phillips, J, Bonneau, M, Anderson, S M, Perry, P, Pearson, M, Constantinides, C, Davidson-Smith, H, Kabiri, M, Duff, B, Johnstone, M, Polites, H G, Lawrie, S M, Blackwood, D H, Semple, C A, Evans, K L, Didier, M, Chandran, S, McIntosh, A M, Price, D J, Houslay, M D, Porteous, D J & Millar, J K 2018, ' DISC1 regulates N-methyl-D-aspartate receptor dynamics : abnormalities induced by a Disc1 mutation modelling a translocation linked to major mental illness ', Translational psychiatry, vol. 8, no. 1, 184 . https://doi.org/10.1038/s41398-018-0228-1
Translational Psychiatry
Translational Psychiatry, Vol 8, Iss 1, Pp 1-16 (2018)

The neuromodulatory gene DISC1 is disrupted by a t(1;11) translocation that is highly penetrant for schizophrenia and affective disorders, but how this translocation affects DISC1 function is incompletely understood. N-Methyl-D-Aspartate receptors (N

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::870cbede3d419f12ab6663ee499dc410

Complex Pharmacology of Novel Allosteric Free Fatty Acid 3 Receptor Ligands

Autor: Graeme Milligan, Brian D. Hudson, Elisabeth Christiansen, Hannah Murdoch, Ole B Madsen, Trond Ulven, Anders Højgaard Hansen, Laura Jenkins

Publikováno v: Hudson, B D, Christiansen, E, Murdoch, H, Jenkins, L, Hansen, A H, Madsen, O, Ulven, T & Milligan, G 2014, ' Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands ', Molecular Pharmacology, vol. 86, no. 2, pp. 200-10 . https://doi.org/10.1124/mol.114.093294

Analysis of the roles of the short chain fatty acid receptor, free fatty acid 3 receptor (FFA3), has been severely limited by the low potency of its endogenous ligands, the crossover of function of these on the closely related free fatty acid 2 recep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5bf2617b489a2b4080f0c84142a576
https://doi.org/10.1124/mol.114.093294

Yield and water use of a ryegrass/white clover sward under different nitrogen and irrigation regimes

Autor: Alistair Black, Hannah Murdoch

Publikováno v: Proceedings of the New Zealand Grassland Association. :157-164

We investigated how N availability affected the wateruse efficiency (WUE) of a perennial ryegrass/white clover sward under different soil moisture regimes at Lincoln. Four combinations of ± N fertiliser and ± irrigation (I) were applied to plots ro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13d225c0987660c4735b3ab6cf35cef4
https://doi.org/10.33584/jnzg.2013.75.2916

Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1

Autor: Hannah Murdoch, Zhong Xie, Miles D. Houslay, Zhen Yan, Manabu Takaki, Akira Sawa, Deepak Srivastava, Yuichi Makino, Nicholas J. Brandon, Toshifumi Tomoda, Nicholas M. Graziane, Akiko Hayashi-Takagi, Allan J. Dunlop, Jay M. Baraban, Anupamaa J Seshadri, Koko Ishizuka, Peter Penzes, Saurav Seshadri, Atsushi Kamiya

Publikováno v: Nature neuroscience

Synaptic spines are dynamic structures that regulate neuronal responsiveness and plasticity. Here we describe a role for the schizophrenia risk factor, Disrupted-in-Schizophrenia 1 (DISC1), in the maintenance of spine morphology and function. We show

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c00f4d8c230395b3abd03fd2facbb0
http://europepmc.org/articles/PMC2846623

Disrupted in schizophrenia 1 and phosphodiesterase 4B: towards an understanding of psychiatric illness

Autor: Sheila Christie, Steven J. Clapcote, Hannah Murdoch, Shaun Mackie, John C. Roder, David J. Porteous, Ben S. Pickard, Walter J. Muir, Douglas Blackwood, Miles D. Houslay, J. Kirsty Millar

Publikováno v: The Journal of Physiology. 584:401-405

Disrupted in schizophrenia 1 (DISC1) is one of the most convincing genetic risk factors for major mental illness identified to date. DISC1 interacts directly with phosphodiesterase 4B (PDE4B), an independently identified risk factor for schizophrenia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c21b22a59cbc5aea25459c4fe8b40451
https://doi.org/10.1113/jphysiol.2007.140210