Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Hannah McCalmont"'
Autor:
Quentin Van Thillo, Jolien De Bie, Janith A. Seneviratne, Sofie Demeyer, Sofia Omari, Anushree Balachandran, Vicki Zhai, Wai L. Tam, Bram Sweron, Ellen Geerdens, Olga Gielen, Sarah Provost, Heidi Segers, Nancy Boeckx, Glenn M. Marshall, Belamy B. Cheung, Kiyotaka Isobe, Itaru Kato, Junko Takita, Timothy G. Amos, Ira W. Deveson, Hannah McCalmont, Richard B. Lock, Ethan P. Oxley, Maximilian M. Garwood, Ross A. Dickins, Anne Uyttebroeck, Daniel R. Carter, Jan Cools, Charles E. de Bock
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SPI1 fusion genes in T-cell acute lymphoblastic leukemia (T-ALL) are commonly found with co-occurring NRAS mutations. Here, the authors show that the combination of these oncogenes is necessary to drive T-ALL in a murine model and that the oncogenic
Externí odkaz:
https://doaj.org/article/097bfb27edca4477bb37a09172ff1f71
Autor:
Cedric S. Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E. Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M. Salmon, Adam McCluskey, Richard B. Lock, Phillip J. Robinson, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The tumour microenvironment provides signals to support leukaemic stem cells (LSC) maintenance and chemoresistance. Here, the authors show that disrupting niche-associated signalling by inhibiting receptor-mediated endocytosis with a dynamin GTPase i
Externí odkaz:
https://doaj.org/article/9f9ae7f5fae34540a33d8cb9dbda1467
Autor:
Jo Lynne Rokita, Komal S. Rathi, Maria F. Cardenas, Kristen A. Upton, Joy Jayaseelan, Katherine L. Cross, Jacob Pfeil, Laura E. Egolf, Gregory P. Way, Alvin Farrel, Nathan M. Kendsersky, Khushbu Patel, Krutika S. Gaonkar, Apexa Modi, Esther R. Berko, Gonzalo Lopez, Zalman Vaksman, Chelsea Mayoh, Jonas Nance, Kristyn McCoy, Michelle Haber, Kathryn Evans, Hannah McCalmont, Katerina Bendak, Julia W. Böhm, Glenn M. Marshall, Vanessa Tyrrell, Karthik Kalletla, Frank K. Braun, Lin Qi, Yunchen Du, Huiyuan Zhang, Holly B. Lindsay, Sibo Zhao, Jack Shu, Patricia Baxter, Christopher Morton, Dias Kurmashev, Siyuan Zheng, Yidong Chen, Jay Bowen, Anthony C. Bryan, Kristen M. Leraas, Sara E. Coppens, HarshaVardhan Doddapaneni, Zeineen Momin, Wendong Zhang, Gregory I. Sacks, Lori S. Hart, Kateryna Krytska, Yael P. Mosse, Gregory J. Gatto, Yolanda Sanchez, Casey S. Greene, Sharon J. Diskin, Olena Morozova Vaske, David Haussler, Julie M. Gastier-Foster, E. Anders Kolb, Richard Gorlick, Xiao-Nan Li, C. Patrick Reynolds, Raushan T. Kurmasheva, Peter J. Houghton, Malcolm A. Smith, Richard B. Lock, Pichai Raman, David A. Wheeler, John M. Maris
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1675-1689.e9 (2019)
Summary: Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and li
Externí odkaz:
https://doaj.org/article/5a7054ef48fe4832b69df7b358c3a0d5
Autor:
Linda Craig, Radi Haloub, Heather Reid, Dalrene Masson, Hannah Mccalmont, Kathy Fodey, Barbara R. Conway, William J. Lattyak, Elizabeth A. Lattyak, Amie Bain, Sayer Al-Azzam, Mamoon A. Aldeyab
Publikováno v:
Vaccines, Vol 9, Iss 10, p 1160 (2021)
The Coronavirus 2019 (COVID-19) pandemic disproportionately affected people living and working in care homes. This study aimed to explore the experience of care home managers on the implementation and uptake of the COVID-19 vaccination programme by r
Externí odkaz:
https://doaj.org/article/1900809e1bd54c6ab971024756860017
Autor:
Cedric S. Tremblay, Sung Kai Chiu, Jesslyn Saw, Hannah McCalmont, Veronique Litalien, Jacqueline Boyle, Stefan E. Sonderegger, Ngoc Chau, Kathryn Evans, Loretta Cerruti, Jessica M. Salmon, Adam McCluskey, Richard B. Lock, Phillip J. Robinson, Stephen M. Jane, David J. Curtis
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-21688-1
Externí odkaz:
https://doaj.org/article/9846dc9e5dfd409a8bf2b3f5a56fc30d
Autor:
Ernest Moles, Christopher B. Howard, Pie Huda, Mawar Karsa, Hannah McCalmont, Kathleen Kimpton, Alastair Duly, Yongjuan Chen, Yizhou Huang, Melinda L. Tursky, David Ma, Sonia Bustamante, Russell Pickford, Patrick Connerty, Sofia Omari, Christopher J. Jolly, Swapna Joshi, Sylvie Shen, John E. Pimanda, Alla Dolnikov, Laurence C. Cheung, Rishi S. Kotecha, Murray D. Norris, Michelle Haber, Charles E. de Bock, Klaartje Somers, Richard B. Lock, Kristofer J. Thurecht, Maria Kavallaris
Publikováno v:
Science Translational Medicine. 15
High-risk childhood leukemia has a poor prognosis because of treatment failure and toxic side effects of therapy. Drug encapsulation into liposomal nanocarriers has shown clinical success at improving biodistribution and tolerability of chemotherapy.
Autor:
John Toubia, Hannah McCalmont, Debora A. Casolari, Chelsea Mayoh, Saumya E. Samaraweera, Richard J D'Andrea, Sarah C Bray, Ka Leung Li, Ian D. Lewis, Rab K. Prinjha, Nicholas Smithers, Luke Jones, Shudong Wang, Richard B. Lock
Publikováno v:
Blood Advances. 4:296-300
Chromosomal rearrangements of the lysine methyltransferase 2A (KMT2A or MLL) gene are observed in ;10% of all acute leukemias, with particularly high frequency (;80%) in infant acute lymphoblastic leukemia (ALL),1 where, despite aggressive chemothera
Autor:
Timothy G. Amos, Janith A. Seneviratne, Quentin Van Thillo, Hannah McCalmont, Wai L. Tam, Jan Cools, Ira W. Deveson, Jolien De Bie, Sofie Demeyer, Nancy Boeckx, Richard B. Lock, Vicki Zhai, Sarah Provost, Kiyotaka Isobe, Junko Takita, Anne Uyttebroeck, Heidi Segers, Olga Gielen, Daniel R. Carter, Ethan P. Oxley, Charles E. de Bock, Bram Sweron, Maximilian M. Garwood, Belamy B. Cheung, Glenn M. Marshall, Ross A. Dickins, Anushree Balachandran, Itaru Kato, Ellen Geerdens, Sofia Omari
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Nature Communications
Spi-1 Proto-Oncogene (SPI1) fusion genes are recurrently found in T-cell acute lymphoblastic leukemia (T-ALL) cases but are insufficient to drive leukemogenesis. Here we show that SPI1 fusions in combination with activating NRAS mutations drive an im
Autor:
Karlheinz Friedrich, Narges Bayat, Hannah McCalmont, Peter R. Schofield, Savvas N. Savvides, Maria Kavallaris, Andreas Wohlmann, Daniel Christ, Richard B. Lock, Kenneth Verstraete, Sara M.A. Mohamed, Keith C.S. Sia
Publikováno v:
International journal of biological macromolecules. 190
Antibody fragments are promising building blocks for developing targeted therapeutics, thus improving treatment efficacy while minimising off-target toxicity. Despite recent advances in targeted therapeutics, patients with Philadelphia-like acute lym
Autor:
Hannah McCalmont, Phillip J. Robinson, Veronique Litalien, Loretta Cerruti, Jacqueline Boyle, Stephen M. Jane, Sung Kai Chiu, Richard B. Lock, David J. Curtis, Adam McCluskey, Jessica M. Salmon, Ngoc Chau, Kathryn Evans, Stefan Eugen Sonderegger, Jesslyn Saw, Cedric S. Tremblay
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Intensive chemotherapy for acute leukemia can usually induce complete remission, but fails in many patients to eradicate the leukemia stem cells responsible for relapse. There is accumulating evidence that these relapse-inducing cells are maintained