Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hannah M. Simpson"'
Publikováno v:
International Journal of Healthcare Simulation. 1:49-55
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efa6ebf94e74141cb3ecbe840075f840
https://doi.org/10.54531/inrx6536
https://doi.org/10.54531/inrx6536
Autor:
Arun K. Ghosh, Jacqueline N. Williams, Rachel Y. Ho, Hannah M. Simpson, Shin-ichiro Hattori, Hironori Hayashi, Johnson Agniswamy, Yuan-Fang Wang, Irene T. Weber, Hiroaki Mitsuya
Publikováno v:
Journal of Medicinal Chemistry. 61:9722-9737
We have designed, synthesized, and evaluated a new class of potent HIV-1 protease inhibitors with novel bicyclic oxazolidinone derivatives as the P2 ligand. We have developed an enantioselective synthesis of these bicyclic oxazolidinones utilizing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42cd656aaa4328da9c883c0350e91967
https://doi.org/10.1021/acs.jmedchem.8b01227
https://doi.org/10.1021/acs.jmedchem.8b01227
Autor:
Arun K. Ghosh, D. Eric Walters, Jacqueline N. Williams, Hannah M. Simpson, Jun Takayama, Satish Kovela, Manabu Aoki, Hiroaki Mitsuya, Shin-ichiro Hattori
Publikováno v:
Bioorg Med Chem Lett
We describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing a squaramide-derived scaffold as the P2 ligand in combination with a (R)-hydroxyethylamine sulfonamide isostere. Inhibitor 3h with an N-methyl-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20bf4062e2e25a583833b30d99112670
https://pubmed.ncbi.nlm.nih.gov/31416666
https://pubmed.ncbi.nlm.nih.gov/31416666
Publikováno v:
Organicbiomolecular chemistry. 16(33)
Enantioselective syntheses of decytospolide A and decytospolide B are described here. The current synthesis highlights an Achmatowicz rearrangement of an optically active furanyl alcohol followed by reduction of the resulting dihydropyranone hemiacet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2e06ed8a3abfade744134cffadf648
https://pubmed.ncbi.nlm.nih.gov/30083684
https://pubmed.ncbi.nlm.nih.gov/30083684
Dissertation/ Thesis
Autor:
Hannah M Simpson (9755462)
Decytospolides A and B are natural products isolated from Cytospora sp. No ZW02 that show mild anticancer properties. The interest in synthesizing these compound lies not in their activities, but rather the simplicity of the structure which could eas
