Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Hannah M. Holst"'
Publikováno v:
Org Lett
We report that the treatment of unsymmetrical 2,3-disubstituted aziridines with TiCl(4) yields β-phenethylamine products via the intermediacy of a phenonium ion. Derivatization of the products obtained via this method is demonstrated. Computational
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7eeb516247e1c2ff394325237e51a01
https://doi.org/10.1021/acs.orglett.1c03857
https://doi.org/10.1021/acs.orglett.1c03857
Publikováno v:
Synlett. 32:01-06
Formation of phenonium ions through anchimeric assistance (neighboring-group participation) of aryl rings has been known since 1949. Although these reactive intermediates have been studied extensively by physical organic chemists, their potential as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::841ee64f051ba193842bf53a597cf0f0
https://doi.org/10.1055/s-0040-1706420
https://doi.org/10.1055/s-0040-1706420
Publikováno v:
Journal of the American Chemical Society. 142:8090-8096
We report the first examples of selective and regiodivergent opening of unsymmetrical phenonium ions with chloride ions. These reactions are enabled by the dual role of SnCl4 and TiCl4 as Lewis acids and chloride nucleophiles. Reagent control dictate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9401a5ba5ba83891ea239a0897961b27
https://doi.org/10.1021/jacs.0c02095
https://doi.org/10.1021/jacs.0c02095