Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Hannah M Stoveken"'
Autor:
Stefanie Giera, Rong Luo, Yanqin Ying, Sarah D Ackerman, Sung-Jin Jeong, Hannah M Stoveken, Christopher J Folts, Christina A Welsh, Gregory G Tall, Beth Stevens, Kelly R Monk, Xianhua Piao
Publikováno v:
eLife, Vol 7 (2018)
In the central nervous system (CNS), myelin formation and repair are regulated by oligodendrocyte (OL) lineage cells, which sense and integrate signals from their environment, including from other glial cells and the extracellular matrix (ECM). The s
Externí odkaz:
https://doaj.org/article/df855cc93c824dc2a33053125a2dd7c0
Autor:
Hannah M. Stoveken, Kirill A. Martemyanov, Dipak N. Patil, Justin Shumate, Thomas D. Bannister, Timothy P. Spicer, Brian S. Muntean, Louis Scampavia, Virneliz Fernandez-Vega
Publikováno v:
SLAS Discov
Regulators of G protein signaling (RGS) proteins serve as critical regulatory nodes to limit the lifetime and extent of signaling via G protein-coupled receptors (GPCRs). Previously, approaches to pharmacologically inhibit RGS activity have mostly fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4c99e2a226d6835ee891d54d5d0ed43
https://doi.org/10.1177/24725552211020679
https://doi.org/10.1177/24725552211020679
Autor:
Maiya Yu, Xianhua Piao, Emily N Stringham, Rong Luo, Jennifer Yeung, Gregory G. Tall, Hannah M. Stoveken, Luciana K. Rosselli-Murai, Alexander Vizurraga, Reheman Adili, Michael Holinstat
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We identified the known collagen receptor GPR56/ADGRG1 on platelets. GPR56 is an adhesion G protein-coupled receptor that becomes activated following forced dissociation of its N-terminal fragment and C-terminal fragment or seven-transme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac5cf9ef5408c578858c7bfe6c45377
https://doi.org/10.1073/pnas.2008921117
https://doi.org/10.1073/pnas.2008921117
Autor:
Alex Vizurraga, Tiago Palmisano, Gregory G. Tall, Dyke P. McEwen, Nevin A. Lambert, Hannah M. Stoveken, Jonathan A. Javitch, Asuka Inoue, Nicole A. Perry, Najeah Okashah, Tobias Langenhan, Signe Mathiasen
Publikováno v:
Nature Chemical Biology. 16:1343-1350
The adhesion G-protein-coupled receptor (GPCR) latrophilin 3 (ADGRL3) has been associated with increased risk of attention deficit hyperactivity disorder (ADHD) and substance use in human genetic studies. Knockdown in multiple species leads to hyperl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21ab0b8187597f30172c434e1adeaa9a
https://doi.org/10.1038/s41589-020-0617-7
https://doi.org/10.1038/s41589-020-0617-7
Publikováno v:
Journal of Biological Chemistry. 295:10822-10830
The interplay between G protein–coupled receptors (GPCRs) is critical for controlling neuronal activity that shapes neuromodulatory outcomes. Recent evidence indicates that the orphan receptor GPR139 influences opioid modulation of key brain circui
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d580f7364d259092793687f6646a70f
https://doi.org/10.1074/jbc.ac120.014770
https://doi.org/10.1074/jbc.ac120.014770
Autor:
Andrew C. Giles, Caitlin Johnston, Ikuo Masuho, Kirill A. Martemyanov, Stefano Zucca, Erik A. Lundquist, Brock Grill, Maria Dao, Hannah M. Stoveken, Matthew S. Gill, Dandan Wang, Chenghui Song, Cesare Orlandi, Karla J. Opperman
Publikováno v:
Science. 365:1267-1273
Worms yield opioid receptor insight The µ-opioid receptor (MOR) is the target of pain-reducing drugs, including morphine and the potent synthetic opioid fentanyl. Better understanding of the receptor system is needed to suppress potentially deadly s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d746d65c4ff3117ff179798dd525944f
https://doi.org/10.1126/science.aau2078
https://doi.org/10.1126/science.aau2078
Autor:
Nycole Maza, Dandan Wang, Cody Kowalski, Hannah M. Stoveken, Maria Dao, Omar K. Sial, Andrew C. Giles, Brock Grill, Kirill A. Martemyanov
Publikováno v:
Nat Neurosci
Repeated exposure to opioids causes tolerance, which limits their analgesic utility and contributes to overdose and abuse liability. However, the molecular mechanisms underpinning tolerance are not well understood. Here, we used a forward genetic scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c791988382102fdaade06a449574af4
https://pubmed.ncbi.nlm.nih.gov/35982154
https://pubmed.ncbi.nlm.nih.gov/35982154
Publikováno v:
Neuropsychopharmacology
Orphan G protein Coupled Receptors (GPCRs) present attractive targets both for understanding neuropsychiatric diseases and for development of novel therapeutics. GPR139 is an orphan GPCR expressed in select brain circuits involved in controlling move
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76f14551baf33bbb63592412f5f6861d
https://europepmc.org/articles/PMC8882194/
https://europepmc.org/articles/PMC8882194/
Autor:
Jana Winkler, Hannah M. Stoveken, Gregory G. Tall, Katherine Leon, Katarzyna Merdas, Pradnya Narkhede, Amanuel Kibrom, Simone Prömel, Yue Lu, Demet Araç, Olha V. Nazarko, Gabriel S. Salzman
Publikováno v:
iScience, Vol 3, Iss, Pp 264-278 (2018)
Summary: Adhesion G-protein-coupled receptors (aGPCRs) play critical roles in diverse cellular processes in neurobiology, development, immunity, and numerous diseases. The lack of molecular understanding of their activation mechanisms, especially wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bffa238207238845be431347aef3191
https://doi.org/10.1016/j.isci.2018.04.019
https://doi.org/10.1016/j.isci.2018.04.019
Autor:
Paul F. Bray, Yogendra Kanthi, Benjamin E. Tourdot, Gregory G. Tall, Leonard C. Edelstein, Jennifer Yeung, Hannah M. Stoveken, Michael Holinstat, Derek Trumbo
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology
Supplemental Digital Content is available in the text.
Objective— Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signa
Objective— Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9875e650f81c8353ac168f089102db36
http://europepmc.org/articles/PMC6023764
http://europepmc.org/articles/PMC6023764