Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Hannah M Burgess"'
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010099 (2022)
The mRNA 5' cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly regul
Externí odkaz:
https://doaj.org/article/58f67aa922ba4ece9d0054a02ca771dc
Autor:
Rupert Ollinger, Andrew J Childs, Hannah M Burgess, Robert M Speed, Pia R Lundegaard, Nicola Reynolds, Nicola K Gray, Howard J Cooke, Ian R Adams
Publikováno v:
PLoS Genetics, Vol 4, Iss 9, p e1000199 (2008)
As genetic information is transmitted through successive generations, it passes between pluripotent cells in the early embryo and germ cells in the developing foetus and adult animal. Tex19.1 encodes a protein of unknown function, whose expression is
Externí odkaz:
https://doaj.org/article/d9aacbdcd60f44848bc41f080a15718b
Publikováno v:
Cell Reports, Vol 39, Iss 5, Pp 110767- (2022)
Summary: Regulated loading of eIF3-bound 40S ribosomes on capped mRNA is generally dependent upon the translation initiation factor eIF4E; however, mRNA translation often proceeds during physiological stress, such as virus infection, when eIF4E avail
Externí odkaz:
https://doaj.org/article/c705042429144d6ebfd359d73594fbe2
Autor:
Julie Alejo, Camelia Iancu-Rubin, Stefania Pittaluga, Ian Mohr, Grace Smith, Judith S. Hochman, Hannah M. Burgess, Seda Bilaloglu, Mark S. Lifshitz, MacIntosh Cornwell, Tessa J. Barrett, Homam Ibrahim, Jun Wang, Vitor W Virginio, Yin Aphinyanaphongs, Eugene Yuriditsky, Jeffrey S. Berger, Feng Xia Liang, Kenneth A. Stapleford, Kelly V. Ruggles, Kamelia Drenkova, Amy Rapkiewicz
Publikováno v:
Journal of Thrombosis and Haemostasis
Objective Heightened inflammation, dysregulated immunity, and thrombotic events are characteristic of hospitalized COVID‐19 patients. Given that platelets are key regulators of thrombosis, inflammation, and immunity they represent prime candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f66f821fd318dac3ce8d5613b61ace7e
https://doi.org/10.1111/jth.15534
https://doi.org/10.1111/jth.15534
Publikováno v:
Genesdevelopment. 36(3-4)
With their categorical requirement for host ribosomes to translate mRNA, viruses provide a wealth of genetically tractable models to investigate how gene expression is remodeled post-transcriptionally by infection-triggered biological stress. By co-o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2ea80d55f68b090144f9bde3a6a5ea
https://pubmed.ncbi.nlm.nih.gov/35193946
https://pubmed.ncbi.nlm.nih.gov/35193946
The mRNA 5’ cap structure serves both to protect transcripts from degradation and promote their translation. Cap removal is thus an integral component of mRNA turnover that is carried out by cellular decapping enzymes, whose activity is tightly reg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bef59608161810d05ded89785a4ea515
https://doi.org/10.1101/2021.11.10.468017
https://doi.org/10.1101/2021.11.10.468017
Autor:
Alexander T. Fields, Eugene Yuriditsky, Amy Rapkiewicz, Antoine Biebuyck, Lucy Z. Kornblith, Tessa J. Barrett, Judith S. Hochman, Stefania Pittaluga, Matthew D. Neal, Yuhe Xia, Michael Tawil, Paolo Cotzia, Kamelia Drenkova, MacIntosh Cornwell, Khrystyna Myndzar, Ian Mohr, Grace Smith, Kenneth A. Stapleford, Kelly V. Ruggles, Christina C. Rolling, Jeffrey S. Berger, Elliot Luttrell-Williams, Deepak Voora, Hannah M. Burgess
Publikováno v:
Science advances, vol 7, iss 37
Given the evidence for a hyperactive platelet phenotype in COVID-19, we investigated effector cell properties of COVID-19 platelets on endothelial cells (ECs). Integration of EC and platelet RNA sequencing revealed that platelet-released factors in C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e21a0f053f8e0d38bc6a9230e3cf5c
https://escholarship.org/uc/item/5ww3k03m
https://escholarship.org/uc/item/5ww3k03m
Publikováno v:
Cell reports. 39(5)
Regulated loading of eIF3-bound 40S ribosomes on capped mRNA is generally dependent upon the translation initiation factor eIF4E; however, mRNA translation often proceeds during physiological stress, such as virus infection, when eIF4E availability a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fc0fa79b77447fa44cb19eaeed87026
https://pubmed.ncbi.nlm.nih.gov/35508137
https://pubmed.ncbi.nlm.nih.gov/35508137
Publikováno v:
Molecular Therapy: Oncolytics, Vol 8, Iss, Pp 71-81 (2018)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Through the action of two virus-encoded decapping enzymes (D9 and D10) that remove protective caps from mRNA 5′-termini, Vaccinia virus (VACV) accelerates mRNA decay and limits activation of host defenses. D9- or D10-deficient VACV are markedly att
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b599d5bd1742022a5d69e0373778dde0
http://www.sciencedirect.com/science/article/pii/S2372770518300019
http://www.sciencedirect.com/science/article/pii/S2372770518300019
Autor:
Ian Mohr, Hannah M. Burgess
In response to virus-induced shutoff host protein synthesis, dynamic aggregates containing mRNA, RNA-binding proteins and translation factors termed stress granules (SGs) often accumulate within the cytoplasm. SGs typically form following phosphoryla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::059b3476a1b446411d2a7abc7c21fd12
https://europepmc.org/articles/PMC6052315/
https://europepmc.org/articles/PMC6052315/