Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Hannah M, Kerns"'
Autor:
Alex Pellerin, Karel Otero, Julie M Czerkowicz, Hannah M Kerns, Renée I Shapiro, Ann M Ranger, Kevin L Otipoby, Frederick R Taylor, Thomas O Cameron, Joanne L Viney, Dania Rabah
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 4, Pp 464-476 (2015)
Abstract Type I interferons (IFN‐I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the sec
Externí odkaz:
https://doaj.org/article/9ceab9bde5004b959003e383c7a33823
Autor:
Agnes Gardet, Wei C Chou, Taylor L Reynolds, Diana B Velez, Kai Fu, Julia M Czerkowicz, Jeffrey Bajko, Ann M Ranger, Normand Allaire, Hannah M Kerns, Sarah Ryan, Holly M Legault, Robert W Dunstan, Robert Lafyatis, Matvey Lukashev, Joanne L Viney, Jeffrey L Browning, Dania Rabah
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://doaj.org/article/de2edfb8f586497f81cac95be2baa6e6
Autor:
Jayanth V. Chodaparambil, Benbo Gao, Gregory M Dillon, Hannah M. Kerns, Jaclyn L. Henderson, Douglas Marcotte, Ru Wei, Bekim Bajrami, Channa Bao
Publikováno v:
Cellular and Molecular Neurobiology. 41:669-685
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::785ba6754ca160aed7d4ffda2a0c284a
https://doi.org/10.1007/s10571-020-00875-6
https://doi.org/10.1007/s10571-020-00875-6
Autor:
Michael Rooney, Pei Li, Rachel Groth, James Gilbert, Yuqing Gong, Hannah M. Kerns, Jaeah Kim, Xingrong Liu
Publikováno v:
Analytical chemistry. 92(15)
Quantitative bioanalysis in plasma and tissues samples is required to study the pharmacokinetic and pharmacodynamic properties of antisense oligonucleotides (ASOs). To overcome intrinsic drawbacks in specificity, sensitivity, and throughput of tradit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c308e89ecc196a026bccde8f0fd260c2
https://pubmed.ncbi.nlm.nih.gov/32628461
https://pubmed.ncbi.nlm.nih.gov/32628461
Autor:
Channa, Bao, Bekim, Bajrami, Douglas J, Marcotte, Jayanth V, Chodaparambil, Hannah M, Kerns, Jaclyn, Henderson, Ru, Wei, Benbo, Gao, Gregory M, Dillon
Publikováno v:
Cellular and molecular neurobiology. 41(4)
Tau-tubulin kinase 1 (TTBK1) is a CNS-specific, kinase that has been implicated in the pathological phosphorylation of tau in Alzheimer's Disease (AD) and Frontotemporal Dementia (FTD). TTBK1 is a challenging therapeutic target because it shares a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6c6ff604205513513cb5b117098fe34
https://pubmed.ncbi.nlm.nih.gov/32424773
https://pubmed.ncbi.nlm.nih.gov/32424773
Autor:
Albanus O. Moguche, Deqiang Niu, Tahmina A. Jahan, Richard G. James, Socheath Khim, Hannah M. Kerns, Beth Browning, Katherine A. Bosch, Swati Singh, Jessica A. Hamerman, M. Nacht, David J. Rawlings, Giacomo Tampella, Alejandro Wolf-Yadlin, Alessandro Plebani, Erica Evans, Meghan E. Garrett
Publikováno v:
The Journal of Immunology. 195:246-256
Previous work has shown conflicting roles for Tec family kinases in regulation of TLR-dependent signaling in myeloid cells. In the present study, we performed a detailed investigation of the role of the Tec kinases Btk and Tec kinases in regulating T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eece15776d49c3cc655e73f417f69fde
https://doi.org/10.4049/jimmunol.1403238
https://doi.org/10.4049/jimmunol.1403238
Autor:
Dania Rabah, Thomas Cameron, Alex Pellerin, Hannah M. Kerns, Frederick R. Taylor, Kevin L. Otipoby, Julie Czerkowicz, Renee I. Shapiro, Karel Otero, Ann Ranger, Joanne L. Viney
Publikováno v:
EMBO Molecular Medicine
Type I interferons (IFN-I) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). In SLE, immune complexes bind to the CD32a (FcγRIIa) receptor on the surface of plasmacytoid dendritic cells (pDCs) and stimulate the secretion of I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b6bf43a25332ae182f915a160b4209e
http://europepmc.org/articles/PMC4403047
http://europepmc.org/articles/PMC4403047
Autor:
Dania Rabah, Sarah Ryan, Robert Dunstan, Julia M. Czerkowicz, Taylor L. Reynolds, Kai Fu, Normand Allaire, Jeffrey L. Browning, Matvey E. Lukashev, Agnes Gardet, Joanne L. Viney, Wei C. Chou, Ann Ranger, Hannah M. Kerns, Jeffrey Bajko, Holly M. Legault, Diana B. Velez, Robert Lafyatis
Publikováno v:
PLoS ONE, Vol 11, Iss 10, p e0164423 (2016)
PLoS ONE
PLoS ONE
Mouse models lupus nephritis (LN) have provided important insights into disease pathogenesis, although none have been able to recapitulate all features of the human disease. Using comprehensive longitudinal analyses, we characterized a novel accelera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4ffcf6e7f9b0c091105433f5dc7b58
http://europepmc.org/articles/PMC5070861?pdf=render
http://europepmc.org/articles/PMC5070861?pdf=render
Autor:
Blythe D. Sather, Mikhail Garibov, Stephanie Humblet-Baron, Alexander Astrakhan, Byoung Y. Ryu, Hannah M. Kerns, Brigid V. Stirling, David J. Rawlings
Publikováno v:
Molecular therapy : the journal of the American Society of Gene Therapy. 19(3)
Sustained, targeted, high-level transgene expression in primary B lymphocytes may be useful for gene therapy in B cell disorders. We developed several candidate B-lineage predominant self-inactivating lentiviral vectors (LV) containing alternative en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5eedb10cfb10f53a275254b81d5dec2
https://pubmed.ncbi.nlm.nih.gov/21139568
https://pubmed.ncbi.nlm.nih.gov/21139568
Autor:
David J. Rawlings, Byoung Y. Ryu, Denny Liggitt, Brigid V. Stirling, Blythe D. Sather, Hannah M. Kerns, Stephanie Humblet-Baron, Alexander Astrakhan
Publikováno v:
Blood. 115(11)
The immunodeficiency disorder, X-linked agammaglobulinemia (XLA), results from mutations in the gene encoding Bruton tyrosine kinase (Btk). Btk is required for pre-B cell clonal expansion and B-cell antigen receptor signaling. XLA patients lack matur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673ae825ad3c7e0f2dd1a2e9826aa7aa
https://pubmed.ncbi.nlm.nih.gov/20093406
https://pubmed.ncbi.nlm.nih.gov/20093406