Defining the age-dependent and tissue-specific circadian transcriptome in male mice

Autor: Christopher A. Wolff, Miguel A. Gutierrez-Monreal, Lingsong Meng, Xiping Zhang, Lauren G. Douma, Hannah M. Costello, Collin M. Douglas, Elnaz Ebrahimi, Ann Pham, Aline C. Oliveira, Chunhua Fu, Amy Nguyen, Bryan R. Alava, Stuart J. Hesketh, Andrew R. Morris, Mehari M. Endale, G. Ryan Crislip, Kit-yan Cheng, Elizabeth A. Schroder, Brian P. Delisle, Andrew J. Bryant, Michelle L. Gumz, Zhiguang Huo, Andrew C. Liu, Karyn A. Esser

Publikováno v: Cell Reports, Vol 42, Iss 1, Pp 111982- (2023)

Summary: Cellular circadian clocks direct a daily transcriptional program that supports homeostasis and resilience. Emerging evidence has demonstrated age-associated changes in circadian functions. To define age-dependent changes at the systems level

Externí odkaz: https://doaj.org/article/2f18b4dcc2854c8b81ce1f23e09506dc

Sodium–glucose cotransporter 2 inhibition does not improve the acute pressure natriuresis response in rats with type 1 diabetes

Autor: Natalie K. Jones, Hannah M. Costello, Marie‐Louise T. Monaghan, Kevin Stewart, David Binnie, Joanne Marks, Matthew A. Bailey, Geoffrey J. Culshaw

Publikováno v: Jones, N, Costello, H, Monaghan, M-L, Stewart, K, Binnie, D, Marks, J, Bailey, M A & Culshaw, G 2023, ' Sodium-glucose co-transporter 2 inhibition does not improve the acute pressure natriuresis response in rats with Type 1 diabetes ', Experimental Psychology, vol. 108, no. 3, pp. 480-490 . https://doi.org/10.1113/EP090849
Jones, N, Costello, H, Monaghan, M-L, Stewart, K, Binnie, D, Marks, J, Bailey, M A & Culshaw, G 2023, ' Sodium–glucose cotransporter 2 inhibition does not improve the acute pressure natriuresis response in rats with type 1 diabetes ', Experimental physiology, vol. 10, no. 3, pp. 480-490 . https://doi.org/10.1113/EP090849

New Findings: What is the central question of this study? Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce cardiovascular risk in patients with both diabetic and non-diabetic kidney disease: can SGLT2 inhibition improve renal pressure natri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::828d3b7a35487f24996964e34427cbb5
https://doi.org/10.1113/ep090849

Circadian clocks of the kidney: function, mechanism, and regulation

Autor: Hannah M. Costello, Jermaine G. Johnston, Alexandria Juffre, G. Ryan Crislip, Michelle L. Gumz

Publikováno v: Physiological Reviews. 102:1669-1701

An intrinsic cellular circadian clock is located in nearly every cell of the body. The peripheral circadian clocks within the cells of the kidney contribute to the regulation of a variety of renal processes. In this review, we summarize what is curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbb4ac75afaf7d127c1c2eda17b8259
https://doi.org/10.1152/physrev.00045.2021

Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems

Autor: G. Ryan Crislip, Jermaine G. Johnston, Lauren G. Douma, Hannah M. Costello, Alexandria Juffre, Kyla Boyd, Wendy Li, Cheoting C. Maugans, Miguel Gutierrez‐Monreal, Karyn A. Esser, Andrew J. Bryant, Andrew C. Liu, Michelle L. Gumz

Publikováno v: Comprehensive Physiology. :2769-2798

Nearly every system within the body contains an intrinsic cellular circadian clock. The circadian clock contributes to the regulation of a variety of homeostatic processes in mammals through the regulation of gene expression. Circadian disruption of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4537d5957dcfab201f4f2306a4116945
https://doi.org/10.1002/cphy.c210011

The Circadian Clock Protein PER1 is Important in Maintaining Endothelin Axis Regulation in Dahl Salt Sensitive Rats

Autor: Hannah M. Costello, Alexandria Juffre, Kit-Yan Cheng, Phillip Bratanatawira, G. Ryan Crislip, Adrian Zietara, Denisha R. Spires, Alexander Staruschenko, Lauren G. Douma, Michelle L. Gumz

Publikováno v: Canadian journal of physiology and pharmacology.

Endothelin-1 (ET-1) is a peptide hormone that acts on its receptors to regulate sodium handling in the kidney's collecting duct. Dysregulation of the endothelin axis is associated with various diseases, including salt-sensitive hypertension and chron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f64c6ac17854d0ebbfbe8a1897b52a
https://pubmed.ncbi.nlm.nih.gov/36450128