Perceptual Health and Wellbeing, Self-Reported Sleep, and Hydration Status in Youth Soccer Players During Competition

Autor: Michael King, Rachel Kimble, Matthew Brown, Seamus McCafferty, Hannah Lithgow

Publikováno v: Journal of Nutrition and Metabolism, Vol 2024 (2024)

Conclusion: It is important to consider sleep strategies to mitigate the potential impact of lack of sleep following match play. Self-reported sleep seems to be appropriate for estimating individual components of health and wellbeing, and therefore m

Externí odkaz: https://doaj.org/article/ec043f0fa07d4686ab044f0445fe4b5a

Exercise acutely increases vitamin D receptor expression in T lymphocytes in vitamin D‐deficient men, independent of age

Autor: Gary Duncan, Melanie Leggate, Hannah Lithgow, Geraint Florida-James, Mark Ross

Publikováno v: Experimental Physiology. 106:1460-1469

New findings What is the central question of this study? Does exercise affect vitamin D receptor expression in T lymphocytes in young, middle-aged and older adults? What is the main finding and its importance? Moderate-intensity cycling exercise incr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55207c178615a4db9c855eb302a7b487
https://doi.org/10.1113/ep089480

Effect of Exercise Intensity and Duration on Cardiac Troponin Release

Autor: Neeraj Dhaun, Mark Ross, Stacey Stewart, Lucy Marshall, Catherine L. Stables, Nicholas L. Mills, Atul Anand, Amy V. Ferry, Andrew R. Chapman, Adam Wild, Hannah Lithgow, Fiona E. Strachan, Takeshi Fujisawa, Kuan Ken Lee, Anoop S V Shah

Publikováno v: Marshall, L, Lee, K, Stewart, S, Wild, A, Fujisawa, T, Ferry, A V, Stables, C, Lithgow, H, Chapman, A, Anand, A, Shah, A S, Dhaun, N, Strachan, F, Mills, N & Ross, M D 2019, ' Effect of Exercise Intensity and Duration on Cardiac Troponin Release ', Circulation . https://doi.org/10.1161/CIRCULATIONAHA.119.041874
Circulation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560fcac00b3fad8d111d85bf9c1e52d0
https://hdl.handle.net/20.500.11820/878fc976-b836-4305-8c65-cafff53915fa

PROTAC-mediated degradation of Bruton's tyrosine kinase is inhibited by covalent binding

Autor: John D. Harling, Hannah Lithgow, William J. Kerr, Marcus Bantscheff, Zuni I. Bassi, Marcel Muelbaier, Han Dai, Ian Edward David Smith, Christopher P. Tinworth, Sophie E. Hughes, Lars Dittus, Glenn A. Burley

The impact of covalent binding on PROTAC-mediated degradation of BTK was investigated through the preparation of both covalent binding and reversible binding PROTACs derived from the covalent BTK inhibitor ibrutinib. It was determined that a covalent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bdbf2c7c16f7218b63c1d96ac63bb6
https://strathprints.strath.ac.uk/67192/1/Tinworth_etal_ACS_CB_2019_PROTAC_mediated_degradation_of_Brutons_tyrosine_kinase.pdf

Small molecule-mediated protein knockdown as a new approach to drug discovery

Autor: Ian Churcher, Hannah Lithgow, Christopher P. Tinworth

Publikováno v: MedChemComm. 7:2206-2216

The concept of using peptidic bifunctional molecules to allow recruitment of ubiquitin E3 ligases to induce the degradation of specific intracellular proteins was first demonstrated in 2001 but, following the extension of this approach to non-peptidi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed6ce50f7c23c0821ca3abfb7ba8cc09
https://doi.org/10.1039/c6md00347h