Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Hannah Limburg"'
Autor:
Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann, Eva Böttcher-Friebertshäuser, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important reside
Externí odkaz:
https://doaj.org/article/5ab97f46113346758e29ef1c0e67adfd
Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells
Autor:
Marie Schwerdtner, Annika Skalik, Hannah Limburg, Jeff Bierwagen, Anna Lena Jung, Jens Dorna, Andreas Kaufmann, Stefan Bauer, Bernd Schmeck, Eva Böttcher-Friebertshäuser
Publikováno v:
Life Science Alliance. 6:e202201813
Many viruses require proteolytic activation of their envelope proteins for infectivity, and relevant host proteases provide promising drug targets. The transmembrane serine protease 2 (TMPRSS2) has been identified as a major activating protease of in
Autor:
Mikhail Matrosovich, Hannah Limburg, Elsayed M. Abdelwhab, Diana Kruhl, Jürgen Stech, David A. Stein, Anne Harbig, Dorothea Bestle, Hong M. Moulton, Eva Böttcher-Friebertshäuser
Publikováno v:
J Virol
Cleavage of the influenza A virus (IAV) hemagglutinin (HA) by host proteases is indispensable for virus replication. Most IAVs possess a monobasic HA cleavage site cleaved by trypsin-like proteases. Previously, the transmembrane protease TMPRSS2 was
Autor:
Olga Dolnik, Eva Böttcher-Friebertshäuser, Torsten Steinmetzer, Dorothea Bestle, Cornelius Rohde, Wolfgang Garten, Stephan Becker, Thuy Van Lam van, Kornelia Hardes, Markus Eickmann, Hannah Limburg, David A. Stein, Miriam Ruth Heindl, Hans-Dieter Klenk, Oliver Pilgram, Hong M. Moulton
In December 2019, a novel coronavirus named SARS-CoV-2 first reported in Wuhan, China, emerged and rapidly spread to numerous other countries globally, causing the current pandemic. SARS-CoV-2 causes acute infection of the respiratory tract (COVID-19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::196228de1e7598635c481cf65c4cd7ba
https://doi.org/10.1101/2020.04.15.042085
https://doi.org/10.1101/2020.04.15.042085
Autor:
Andreas Rembert Koczulla, Hans-Dieter Klenk, Julia Jaeger, Hannah Limburg, Dorothea Bestle, Hong M. Moulton, Leon N. Schulte, David A. Stein, Harshavardhan Janga, Kornelia Hardes, Janine Koepke, Bernd Schmeck, Eva Böttcher-Friebertshäuser, Anne Harbig
Publikováno v:
Journal of Virology
Cleavage of influenza virus hemagglutinin (HA) by host cell proteases is essential for virus infectivity and spread. We previously demonstrated in vitro that the transmembrane protease TMPRSS2 cleaves influenza A virus (IAV) and influenza B virus (IB
Autor:
Kornelia Hardes, Torsten Steinmetzer, Hans-Dieter Klenk, Miriam Ruth Heindl, Olga Dolnik, Oliver Pilgram, Hong M. Moulton, Hannah Limburg, Dorothea Bestle, Markus Eickmann, Wolfgang Garten, Eva Böttcher-Friebertshäuser, David A. Stein, Cornelius Rohde, Thuy Van Lam van
Publikováno v:
Life Science Alliance
The spike protein S of SARS-CoV-2 is activated by TMPRSS2 and furin. Inhibition of either one of these proteases can render the S protein unable to mediate virus entry and, therefore, provides a promising approach for COVID-19 treatment.
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