Výsledky vyhledávání - "Hannah L. Townsend"

A putative loop E motif and an H-H kissing loop interaction are conserved and functional features in a group C enterovirus RNA that inhibits ribonuclease L

Autor: Hannah L. Townsend, Babal K. Jha, Robert H. Silverman, David J. Barton

Publikováno v: RNA Biology. 5:263-272

A phylogenetically conserved RNA structure within the open reading frame of poliovirus and other group C enteroviruses functions as a competitive inhibitor of the antiviral endoribonuclease RNase L. Hence, we call this viral RNA the RNase L competiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1c78ef70b57a1a339620e7fadc7f1a
https://doi.org/10.4161/rna.7165

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A viral RNA competitively inhibits the antiviral endoribonuclease domain of RNase L

Autor: N. Karl Maluf, Jian Qiu Han, Babal K. Jha, Robert H. Silverman, David J. Barton, Hannah L. Townsend

Publikováno v: RNA. 14:1026-1036

Ribonuclease L (RNase L) is a latent endoribonuclease in an evolutionarily ancient interferon-regulated dsRNA-activated antiviral pathway. 2′–5′ oligoadenylate (2–5A), the product of dsRNA-activated oligoadenylate synthetases (OASes), binds t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ee38ec5eda460cebcf80ff6c0a32e03
https://doi.org/10.1261/rna.958908

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A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L

Autor: Robert H. Silverman, David J. Barton, Jayashree M. Paranjape, Babal K. Jha, Hannah L. Townsend, Jian Qiu Han

Publikováno v: Journal of Virology. 81:5561-5572

RNase L is an antiviral endoribonuclease that cleaves viral mRNAs after single-stranded UA and UU dinucleotides. Poliovirus (PV) mRNA is surprisingly resistant to cleavage by RNase L due to an RNA structure in the 3C Pro open reading frame (ORF). The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2dac0494f88a69d066c8065f43d456f
https://doi.org/10.1128/jvi.01857-06

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Accurate Translation of the Genetic Code Depends on tRNA Modified Nucleosides

Autor: Paul F. Agris, Hannah L. Townsend, Elzbieta Sochacka, Connie Yarian, Agnieszka Miskiewicz, Wojciech Czestkowski, Richard H. Guenther, Andrzej Malkiewicz

Publikováno v: Journal of Biological Chemistry. 277:16391-16395

Transfer RNA molecules translate the genetic code by recognizing cognate mRNA codons during protein synthesis. The anticodon wobble at position 34 and the nucleotide immediately 3' to the anticodon triplet at position 37 display a large diversity of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80258f96626c040bf8c7b90ad87d5dfb
https://doi.org/10.1074/jbc.m200253200

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Structural characterization of an intermolecular RNA–RNA interaction involved in the transcription regulation element of a bipartite plant virus

Autor: Guihua Liu, Paul F. Agris, Winnell Newman, Richard H. Guenther, Michael A. Dolan, Hanna S. Gracz, Hannah L. Townsend, Tim L. Sit, Steven A. Lommel

The 34-nucleotide trans-activator (TA) located within the RNA-2 of Red clover necrotic mosaic virus folds into a simple hairpin. The eight-nucleotide TA loop base pairs with eight complementary nucleotides in the TA binding sequence (TABS) of the cap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac72d8bd32ce5aa62ef7aa266f8a4cb5
https://europepmc.org/articles/PMC419593/

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