Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Hannah L. Klein"'
Autor:
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 1-64 (2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily
Externí odkaz:
https://doaj.org/article/9deb4e4edc524ec78e599b9f614eaef3
Publikováno v:
Microbial Cell, Vol 3, Iss 6, Pp 248-254 (2016)
Ribonucleotides can become embedded in DNA from insertion by DNA polymerases, failure to remove Okazaki fragment primers, R-loops that can prime replication, and RNA/cDNA-mediated recombination. RNA:DNA hybrids are removed by RNase H enzymes. Single
Externí odkaz:
https://doaj.org/article/f2e2ef1fe5834c0887e8c7d74d18c01c
Autor:
Yang Sui, Anastasiya Epstein, Margaret Dominska, Dao-Qiong Zheng, Thomas D Petes, Hannah L Klein
Publikováno v:
Nucleic Acids Research. 50:6890-6902
Ribonucleotides can be incorporated into DNA during replication by the replicative DNA polymerases. These aberrant DNA subunits are efficiently recognized and removed by Ribonucleotide Excision Repair, which is initiated by the heterotrimeric enzyme
Autor:
Jonathan A. Lidbury, Hannah L Klein, Mohammad R. Khattab, Amanda B. Blake, Annalis Cigarroa, Theresa Keating, Jan S. Suchodolski, Patti Van De Coevering, Jörg M. Steiner
Publikováno v:
Journal of Veterinary Internal Medicine
Background The fecal microbiota, fecal bile acid concentrations, and abundance of Clostridium perfringens and Clostridium difficile are altered in acute and chronic gastrointestinal disease in adult dogs. However, less is known in young puppies. Hypo
Publikováno v:
Homologous Recombination ISBN: 9781071606438
Spontaneous and induced mitotic recombinations are driven by lesions such as single-strand nicks and gaps and double-strand breaks in the genome. For regions of the genome that are not repetitive, spontaneous recombination rates are too low to be det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ddbb2bf917e4fc65e745c176a0cd032
https://doi.org/10.1007/978-1-0716-0644-5_14
https://doi.org/10.1007/978-1-0716-0644-5_14
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2153
Spontaneous and induced mitotic recombinations are driven by lesions such as single-strand nicks and gaps and double-strand breaks in the genome. For regions of the genome that are not repetitive, spontaneous recombination rates are too low to be det
Autor:
Hannah L. Klein
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Perturbations in DNA replication cause high levels of chromosome rearrangements and it has been suggested that DNA replication stress promotes oncogenesis. In this study, we show that low levels of the DNA polymerases involved in replica
Autor:
Hannah L. Klein
Publikováno v:
DNA Repair. 56:26-32
Genomic DNA is transiently contaminated with ribonucleotide residues during the process of DNA replication through misincorporation by the replicative DNA polymerases α, δ and ε, and by the normal replication process on the lagging strand, which u
Autor:
Hannah L. Klein, Lorraine S. Symington
Publikováno v:
The New England journal of medicine. 381(7)
Discoveries in DNA Repair Recognized through the Shaw Prize The understanding of mechanisms of DNA repair has provided a foundation on which to develop new approaches to cancer treatment and geneti...
Publikováno v:
DNA Repair (Amst)
The RNase H2 complex is a conserved heterotrimeric enzyme that degrades RNA:DNA hybrids and promotes excision of rNMPs misincorporated during DNA replication. Failure to remove ribonucleotides from DNA leads to genomic instability in yeast and humans