The Human Nose Organoid Respiratory Virus Model: an Ex Vivo Human Challenge Model To Study Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pathogenesis and Evaluate Therapeutics

Autor: Anubama Rajan, Ashley Morgan Weaver, Gina Marie Aloisio, Joseph Jelinski, Hannah L. Johnson, Susan F. Venable, Trevor McBride, Letisha Aideyan, Felipe-Andrés Piedra, Xunyan Ye, Ernestina Melicoff-Portillo, Malli Rama Kanthi Yerramilli, Xi-Lei Zeng, Michael A. Mancini, Fabio Stossi, Anthony W. Maresso, Shalaka A. Kotkar, Mary K. Estes, Sarah Blutt, Vasanthi Avadhanula, Pedro A. Piedra

Publikováno v: mBio, Vol 13, Iss 1 (2022)

ABSTRACT There is an unmet need for preclinical models to understand the pathogenesis of human respiratory viruses and predict responsiveness to immunotherapies. Airway organoids can serve as an ex vivo human airway model to study respiratory viral p

Externí odkaz: https://doaj.org/article/d19e06d3907d4ae0a97b769078363018

Abstract P6-11-15: Lipid accumulation in residual triple negative breast cancer cells surviving chemotherapy treatment

Autor: Katherine E. Pendleton, Mokryun L. Baek, Junegoo Lee, Lin Tan, Hannah L. Johnson, Lacey E. Dobrolecki, James P. Barrish, Michael T. Lewis, Philip L. Lorenzi, Fabio Stossi, Gloria V. Echeverria

Publikováno v: Cancer Research. 83:P6-11

Background: Triple negative breast cancer (TNBC) is an aggressive breast cancer subtype for which limited targeted therapies are available. Therefore, conventional chemotherapy remains the backbone of standard neoadjuvant treatment (NACT) for TNBC pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::57f1fa69cc4206aa91aa6feea094f5ab
https://doi.org/10.1158/1538-7445.sabcs22-p6-11-15

Data from Oncogenic Mutations in PI3K/AKT/mTOR Pathway Effectors Associate with Worse Prognosis in BRAFV600E-Driven Papillary Thyroid Cancer Patients

Autor: Iñigo Landa, Erik K. Alexander, Neal I. Lindeman, Gerard M. Doherty, Jochen H. Lorch, Justine A. Barletta, Nancy L. Cho, Matthew A. Nehs, Hannah L. Johnson, Ellen Marqusee, Sara Ahmadi, Theodora Pappa

Purpose:The extent to which routine genomic sequencing can identify relevant secondary genomic alterations among BRAFV600E-mutant papillary thyroid carcinoma (PTC) is unknown. Such markers would prove highly valuable for prognostic purposes.Experimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b68488d64e90ffc393ed2b22b5208ce
https://doi.org/10.1158/1078-0432.c.6530706.v1

A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect

Autor: Kelemen T. Lee, Yu Song, Yasmijn van Oldenbeuving, Karine Tonnu, Marco Salvati, Hannah L. Johnson, Quentin Frederik Gronau, Nicholas Sosa, Michael Inzlicht, Jessica L. Alquist, David D. Loschelder, Brandon J. Schmeichel, Dominic Theodore, Dana C. Leighton, Christian E. Waugh, Wilhelm Hofmann, Victoria Forgea, Christine Lam, Julie Eyink, Konstantyn Sharpinskyi, Lea F. Geraedts, Caitlin N. Kelly, Kaitlyn Spillane, Janelle Sherman, Martin S. Hagger, Collier Campbell, Janie H. Wilson, Maximilian Rath, Michelle R. vanDellen, Emily Johnson, Anna J Finley, Lara K. Kammrath, Yasemin Doğruol, Mindi Price, Kareena del Rosario, Mauro Giacomantonio, Jasper J. Hidding, Nick Lee, Ambra Brizi, Aaron L. Wichman, Jan Helge Kaben, Katja M. Pollak, Akira Miyake, Katharina Diel, Sophie Lohmann, Michael D. Baker, Carine Meslot, Chuting Cau, Wendy Berry Mendes, Andreas B. Eder, Natasha E. Garcia-Willingham, Jasmine Walker, Heather M. Maranges, Jacob A. Robertson, Hannah R. Strawser, Anthony D. Hermann, Brian L. Kissell, Robert D. Hutton, Samantha McCarthy, Edward R. Hirt, Astrid Schütz, Marina Milyavskaya, Megan Doi, Mark Muraven, Benjamin Serenka, Jonathan Capaldi, Erin Nakahara, Kate Sweeny, Craig Wheeler, Elana M. Gloger, Blair Saunders, Heather Chambers, Kennedy Mazara, Weston J. Christensen, Rachel A. White, Mia Ersoff, Malte Friese, Nicholas M. Michalak, Eli J. Finkel, Suzanne C. Segerstrom, Julia Stapels, Samuel L. Clay, Grant J. Butschek, Valeria De Cristofaro, John V. Petrocelli, Angelica Bunyi, Julian Wills, Angelica Falkenstein, Mehrad Moeini-Jazani, Rachael Rockwell, Sander L. Koole, Eric-Jan Wagenmakers, E. J. Masicampo, Meaghan Shaw, Raiza C. Vergara, Haley J. Ramsey, Tina L. Donaldson, Karolin Gieseler, Bryan Gibson, Anand Krishna, Jennifer L. Howell, Sarah Joyce, Carina M. Gobes, Will M. Gervais, Anne Scherer, Matthew B. Findley, Sarah E. Ainsworth, Dolores Albarracín, Justina Gineikiene, Bradford J. Wiggins, Jessica Curtis, Nicole L. Mead, Paul T. Fuglestad, Kristin N. Schmitt, Yannick Joye, Josh Hodge, Ian McGregor, Bob M. Fennis, Isabella F. Russ, Krishna Patel, Kathleen D. Vohs, Bethany Hartsell, Lily James, Nikos L. D. Chatzisarantis, Feline Weise, Alec J. Stinnett, Maria Grande, Kaitlyn M. Werner

Publikováno v: Vohs, K D, Schmeichel, B J, Lohmann, S, Gronau, Q F, Finley, A J, Ainsworth, S E, Alquist, J L, Baker, M D, Brizi, A, Bunyi, A, Butschek, G J, Campbell, C, Capaldi, J, Cau, C, Chambers, H, Chatzisarantis, N L D, Christensen, W J, Clay, S L, Curtis, J, De Cristofaro, V, del Rosario, K, Diel, K, Doğruol, Y, Doi, M, Donaldson, T L, Eder, A B, Ersoff, M, Eyink, J R, Falkenstein, A, Fennis, B M, Findley, M B, Finkel, E J, Forgea, V, Friese, M, Fuglestad, P, Garcia-Willingham, N E, Geraedts, L F, Gervais, W M, Giacomantonio, M, Gibson, B, Gieseler, K, Gineikiene, J, Gloger, E M, Gobes, C M, Grande, M, Hagger, M S, Hartsell, B, Hermann, A D, Hidding, J J, Hirt, E R, Hodge, J, Hofmann, W, Howell, J L, Hutton, R D, Inzlicht, M, James, L, Johnson, E, Johnson, H L, Joyce, S M, Joye, Y, Kaben, J H, Kammrath, L K, Kelly, C N, Kissell, B L, Koole, S L, Krishna, A, Lam, C, Lee, K T, Lee, N, Leighton, D C, Loschelder, D D, Maranges, H M, Masicampo, E J, Mazara, K, McCarthy, S, McGregor, I, Mead, N L, Mendes, W B, Meslot, C, Michalak, N M, Milyavskaya, M, Miyake, A, Moeini-Jazani, M, Muraven, M, Nakahara, E, Patel, K, Petrocelli, J V, Pollak, K M, Price, M M, Ramsey, H J, Rath, M, Robertson, J A, Rockwell, R, Russ, I F, Salvati, M, Saunders, B, Scherer, A, Schütz, A, Schmitt, K N, Segerstrom, S C, Serenka, B, Sharpinskyi, K, Shaw, M, Sherman, J, Song, Y, Sosa, N, Spillane, K, Stapels, J, Stinnett, A J, Strawser, H R, Sweeny, K, Theodore, D, Tonnu, K, van Oldenbeuving, Y, vanDellen, M R, Vergara, R C, Walker, J S, Waugh, C E, Weise, F, Werner, K M, Wheeler, C, White, R A, Wichman, A L, Wiggins, B J, Wills, J A, Wilson, J H, Wagenmakers, E J & Albarracín, D 2021, ' A Multisite Preregistered Paradigmatic Test of the Ego-Depletion Effect ', Psychological Science, vol. 32, no. 10, pp. 1566-1581 . https://doi.org/10.1177/0956797621989733
Psychological Science, 32(10), 1566-1581. SAGE Publications Inc.
Psychological Science, 32(10), 1566-1581. Sage Publications

We conducted a preregistered multilaboratory project ( k = 36; N = 3,531) to assess the size and robustness of ego-depletion effects using a novel replication method, termed the paradigmatic replication approach. Each laboratory implemented one of tw

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c53b424cae4fabc9a59cb44e1b370fed
https://hdl.handle.net/1871.1/e2298ab1-9432-456d-8961-5ed6623d86d6

Single-Cell Distribution Analysis of AR Levels by High-Throughput Microscopy in Cell Models: Application for Testing Endocrine-Disrupting Chemicals

Autor: Maureen G. Mancini, Hannah L. Johnson, Michael A. Mancini, Adam T. Szafran, Ragini Mistry, Pankaj Singh, Fabio Stossi

Publikováno v: SLAS Discov

Cell-to-cell variation of protein expression in genetically homogeneous populations is a common biological trait often neglected during analysis of high-throughput (HT) screens and is rarely used as a metric to characterize chemicals. We have capture

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::579451335355dfe01939d26c9a3197a0
https://doi.org/10.1177/2472555220934420