Výsledky vyhledávání - "Hannah L. Bolt"

Akademický článek

Sequence-based prediction of the intrinsic solubility of peptides containing non-natural amino acids

Autor: Marc Oeller, Ryan J. D. Kang, Hannah L. Bolt, Ana L. Gomes dos Santos, Annika Langborg Weinmann, Antonios Nikitidis, Pavol Zlatoidsky, Wu Su, Werngard Czechtizky, Leonardo De Maria, Pietro Sormanni, Michele Vendruscolo

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Abstract Non-natural amino acids are increasingly used as building blocks in the development of peptide-based drugs as they expand the available chemical space to tailor function, half-life and other key properties. However, while the chemical space

Externí odkaz: https://doaj.org/article/0caac934400240c99334cfb366d281f4

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Akademický článek

Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe, Fusobacterium nucleatum

Autor: Jamie Toole, Hannah L. Bolt, John J. Marley, Sheila Patrick, Steven L. Cobb, Fionnuala T. Lundy

Publikováno v: Molecules, Vol 26, Iss 16, p 4741 (2021)

Peptoids (oligo N-substituted glycines) are peptide analogues, which can be designed to mimic host antimicrobial peptides, with the advantage that they are resistant to proteolytic degradation. Few studies on the antimicrobial efficacy of peptoids ha

Externí odkaz: https://doaj.org/article/48670fe932d44af1b663638899917cb7

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Akademický článek

A procedure for the preparation and isolation of nucleoside-5’-diphosphates

Autor: Heidi J. Korhonen, Hannah L. Bolt, David R. W. Hodgson

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 11, Iss 1, Pp 469-472 (2015)

Tris[bis(triphenylphosphoranylidene)ammonium] pyrophosphate (PPN pyrophosphate) was used in the SN2 displacements of the tosylate ion from 5’-tosylnucleosides to afford nucleoside-5’-diphosphates. Selective precipitation permitted the direct isol

Externí odkaz: https://doaj.org/article/10743f36ce4c4b028f7098b6d0c26616

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Akademický článek

The Role of Phosphoglycans in the Susceptibility of Leishmania mexicana to the Temporin Family of Anti-Microbial Peptides

Autor: Gabriela A. Eggimann, Kathryn Sweeney, Hannah L. Bolt, Neshat Rozatian, Steven L. Cobb, Paul W. Denny

Publikováno v: Molecules, Vol 20, Iss 2, Pp 2775-2785 (2015)

Natural product antimicrobial peptides (AMPs) have been proposed as promising agents against the Leishmania species, insect vector borne protozoan parasites causing the neglected tropical disease leishmaniasis. However, recent studies have shown that

Externí odkaz: https://doaj.org/article/2c8861868fc741f8b2b0e099afb5ac84

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Akademický článek

Synthesis of Antibacterial Nisin–Peptoid Hybrids Using Click Methodology

Autor: Hannah L. Bolt, Laurens H. J. Kleijn, Nathaniel I. Martin, Steven L. Cobb

Publikováno v: Molecules, Vol 23, Iss 7, p 1566 (2018)

Antimicrobial peptides and structurally related peptoids offer potential for the development of new antibiotics. However, progress has been hindered by challenges presented by poor in vivo stability (peptides) or lack of selectivity (peptoids). Herei

Externí odkaz: https://doaj.org/article/6af9f1f98a5f43c0b7973ddf5c8cd1dd

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Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe, Fusobacterium nucleatum

Autor: Steven L. Cobb, Jamie Toole, Hannah L. Bolt, Fionnuala Lundy, J. J. Marley, Sheila Patrick

Publikováno v: Molecules, 2021, Vol.26(16), pp.4741 [Peer Reviewed Journal]
Molecules
Volume 26
Issue 16
Molecules, Vol 26, Iss 4741, p 4741 (2021)
Toole, J, Bolt, H L, Marley, J J, Patrick, S, Cobb, S L & Lundy, F T 2021, ' Peptoids with Antibiofilm Activity against the Gram Negative Obligate Anaerobe, Fusobacterium nucleatum ', Molecules, vol. 26, no. 16, e4741 . https://doi.org/10.3390/molecules26164741

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dc811954b76f3fd1cbda355a8185404
http://dro.dur.ac.uk/33657/

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PPN Pyrophosphate: A New Reagent for the Preparation of Nucleoside Triphosphates

Autor: Hannah L. Bolt, Daniel C. Perks, Leyre Vicente-Gines, David R. W. Hodgson, Heidi Korhonen

Publikováno v: Phosphorus, sulfur, and silicon and the related elements, 2015, Vol.190(5-6), pp.758-762 [Peer Reviewed Journal]

Tris{bis(triphenylphosphoranylidene) ammonium} (PPN) pyrophosphate was accessed via aqueous precipitation and desiccation. The reagent was investigated as a replacement for highly hygroscopic alkylammonium salts in Ludwig-Yoshikawa reactions for the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30211c72b5ec109e09ec0a631dcb5393
https://doi.org/10.1080/10426507.2014.984032

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Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids

Autor: Ronald N. Zuckermann, Elizabeth H. C. Bromley, Steven L. Cobb, C. E. J. Williams, Hannah L. Bolt, R. V. Brooks

Publikováno v: Biopolymers, vol 108, iss 4
Bolt, HL; Williams, CEJ; Brooks, RV; Zuckermann, RN; Cobb, SL; & Bromley, EHC. (2017). Log D versus HPLC derived hydrophobicity: The development of predictive tools to aid in the rational design of bioactive peptoids. Biopolymers, 108(4). doi: 10.1002/bip.23014. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9b47k98c
Peptide science, 2017, Vol.108(4), pp.e23014 [Peer Reviewed Journal]
Biopolymers

© 2017 The Authors PEPSCI Published by Wiley Periodicals, Inc. Hydrophobicity has proven to be an extremely useful parameter in small molecule drug discovery programmes given that it can be used as a predictive tool to enable rational design. For la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a201cb80da7265d8ebe79c84c9b24e1e
https://escholarship.org/uc/item/9b47k98c

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Exploring the links between peptoid antibacterial activity and toxicity

Autor: Gary J. Sharples, Ronald N. Zuckermann, Hannah L. Bolt, Steven L. Cobb, Colin A.B. Jahoda, Gabriela A. Eggimann

Publikováno v: MedChemComm, vol 8, iss 5

Peptoids are a promising class of antimicrobial agents with reported activities against a range of both Gram-positive and Gram-negative bacteria, fungi and most recently parasites. However, at present the available toxicity data is somewhat limited a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac69da0edea8ee8b7bf53630758c1d63
https://escholarship.org/uc/item/2w32r9q4

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An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity

Autor: Steven L. Cobb, Paul W. Denny, Hannah L. Bolt

Publikováno v: Journal of Visualized Experiments : JoVE

This protocol describes the manual solid-phase synthesis of linear peptoids that contain two differently functionalized cationic monomers. In this procedure amino functionalized 'lysine' and guanido functionalized 'arginine' peptoid monomers can be i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e29c8cdd177543762a68e90338150bc
http://europepmc.org/articles/PMC5226131

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