Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Hannah K. Long"'
Autor:
David A. Brown, Vincenzo Di Cerbo, Angelika Feldmann, Jaewoo Ahn, Shinsuke Ito, Neil P. Blackledge, Manabu Nakayama, Michael McClellan, Emilia Dimitrova, Anne H. Turberfield, Hannah K. Long, Hamish W. King, Skirmantas Kriaucionis, Lothar Schermelleh, Tatiana G. Kutateladze, Haruhiko Koseki, Robert J. Klose
Publikováno v:
Cell Reports, Vol 20, Iss 10, Pp 2313-2327 (2017)
Chromatin modifications and the promoter-associated epigenome are important for the regulation of gene expression. However, the mechanisms by which chromatin-modifying complexes are targeted to the appropriate gene promoters in vertebrates and how th
Externí odkaz:
https://doaj.org/article/9b58edca6b994f178ed582935538118f
Autor:
Christina Ernst, Jeremy Pike, Sarah J Aitken, Hannah K Long, Nils Eling, Lovorka Stojic, Michelle C Ward, Frances Connor, Timothy F Rayner, Margus Lukk, Robert J Klose, Claudia Kutter, Duncan T Odom
Publikováno v:
eLife, Vol 5 (2016)
Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmissi
Externí odkaz:
https://doaj.org/article/1f142675989441129d0e1c5ce8d2c48e
Autor:
Hannah K Long, David Sims, Andreas Heger, Neil P Blackledge, Claudia Kutter, Megan L Wright, Frank Grützner, Duncan T Odom, Roger Patient, Chris P Ponting, Robert J Klose
Publikováno v:
eLife, Vol 2 (2013)
Two-thirds of gene promoters in mammals are associated with regions of non-methylated DNA, called CpG islands (CGIs), which counteract the repressive effects of DNA methylation on chromatin. In cold-blooded vertebrates, computational CGI predictions
Externí odkaz:
https://doaj.org/article/8f9b32865ca8491b8fcd154f9776e701
Autor:
Anca M Farcas, Neil P Blackledge, Ian Sudbery, Hannah K Long, Joanna F McGouran, Nathan R Rose, Sheena Lee, David Sims, Andrea Cerase, Thomas W Sheahan, Haruhiko Koseki, Neil Brockdorff, Chris P Ponting, Benedikt M Kessler, Robert J Klose
Publikováno v:
eLife, Vol 1 (2012)
CpG islands (CGIs) are associated with most mammalian gene promoters. A subset of CGIs act as polycomb response elements (PREs) and are recognized by the polycomb silencing systems to regulate expression of genes involved in early development. How CG
Externí odkaz:
https://doaj.org/article/1833a1a5ee634de494ff1570787fe8ab
Autor:
Yiran E. Liu, Diane E. Dickel, Robert Aho, Mervenaz Koska, Hannah K. Long, Neha Arora, Licia Selleri, Matthew H. Porteus, Alexander T. Adams, Ian C. Welsh, Ruth M. Williams, Tatjana Sauka-Spengler, James O.J. Davies, Marco Osterwalder, Douglas R. Higgs, Karissa Hansen, Kazuya Ikeda, Axel Visel, Tomek Swigut, Timothy J. Mohun, Jim R. Hughes, Joanna Wysocka
Publikováno v:
Long, H K, Osterwalder, M, Welsh, I C, Hansen, K, Davies, J O J, Liu, Y E, Koska, M, Adams, A T, Aho, R, Arora, N, Ikeda, K, Williams, R M, Sauka-Spengler, T, Porteus, M H, Mohun, T, Dickel, D E, Swigut, T, Hughes, J R, Higgs, D R, Visel, A, Selleri, L & Wysocka, J 2020, ' Loss of Extreme Long-Range Enhancers in Human Neural Crest Drives a Craniofacial Disorder ', Cell Stem Cell, vol. 27, no. 5, pp. 765-783.e14 . https://doi.org/10.1016/j.stem.2020.09.001
Cell Stem Cell
Cell stem cell, vol 27, iss 5
Cell Stem Cell
Cell stem cell, vol 27, iss 5
Summary Non-coding mutations at the far end of a large gene desert surrounding the SOX9 gene result in a human craniofacial disorder called Pierre Robin sequence (PRS). Leveraging a human stem cell differentiation model, we identify two clusters of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f150da7af4ebb8826bb96a6b61a3a0ca
https://www.pure.ed.ac.uk/ws/files/249582527/Loss_of_Extreme_Long_Range_Enhancers_in_Human.pdf
https://www.pure.ed.ac.uk/ws/files/249582527/Loss_of_Extreme_Long_Range_Enhancers_in_Human.pdf
Autor:
Jacob McClendon, Margot E. Bowen, Hannah K. Long, Jeanine L. Van Nostrand, Joanna Wysocka, Laura D. Attardi, Aryo Sorayya
Publikováno v:
Dev Cell
Bowen, M E, McClendon, J, Long, H K, Sorayya, A, Van Nostrand, J L, Wysocka, J & Attardi, L D 2019, ' The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes ', Developmental Cell, vol. 50, no. 2, pp. 212-228.e6 . https://doi.org/10.1016/j.devcel.2019.05.015
Bowen, M E, McClendon, J, Long, H K, Sorayya, A, Van Nostrand, J L, Wysocka, J & Attardi, L D 2019, ' The Spatiotemporal Pattern and Intensity of p53 Activation Dictates Phenotypic Diversity in p53-Driven Developmental Syndromes ', Developmental Cell, vol. 50, no. 2, pp. 212-228.e6 . https://doi.org/10.1016/j.devcel.2019.05.015
Inappropriate activation of the p53 transcription factor contributes to numerous developmental syndromes characterized by distinct constellations of phenotypes. How p53 drives exquisitely specific sets of symptoms in diverse syndromes, however, remai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::435cd51a0faf12d7c5cce36413e7356d
https://europepmc.org/articles/PMC6650355/
https://europepmc.org/articles/PMC6650355/
Publikováno v:
Methods in Molecular Biology ISBN: 9781493977673
CpG islands are regions of vertebrate genomes that often function as gene regulatory elements and are associated with most gene promoters. CpG island elements usually contain nonmethylated CpG dinucleotides, while the remainder of the genome is perva
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e953103f92f18e0c0cd8cc414798971
https://doi.org/10.1007/978-1-4939-7768-0_2
https://doi.org/10.1007/978-1-4939-7768-0_2
Publikováno v:
Long, H K, Prescott, S L & Wysocka, J 2016, ' Ever-Changing Landscapes : Transcriptional Enhancers in Development and Evolution ', Cell, vol. 167, no. 5, pp. 1170-1187 . https://doi.org/10.1016/j.cell.2016.09.018
A class of cis-regulatory elements, called enhancers, play a central role in orchestrating spatiotemporally precise gene-expression programs during development. Consequently, divergence in enhancer sequence and activity is thought to be an important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4db1e3746d40a28b5dc0e0ca94a43759
https://www.pure.ed.ac.uk/ws/files/249583740/Ever_Changing_Landscapes_Transcriptional_Enhancers_in_Development_and_Evolution.pdf
https://www.pure.ed.ac.uk/ws/files/249583740/Ever_Changing_Landscapes_Transcriptional_Enhancers_in_Development_and_Evolution.pdf
Autor:
Frances Connor, Sarah J. Aitken, Hannah K. Long, Tim Rayner, Christina Ernst, Margus Lukk, Lovorka Stojic, Duncan T. Odom, Nils Eling, Claudia Kutter, Jeremy A. Pike, Robert J. Klose, Michelle C Ward
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea4ecbe058ed41ee571fcc5e17a3445
https://doi.org/10.7554/elife.20235.034
https://doi.org/10.7554/elife.20235.034
Autor:
Margus Lukk, Duncan T. Odom, Hannah K. Long, Robert J. Klose, Michelle C Ward, Claudia Kutter, Tim Rayner, Frances Connor, Lovorka Stojic, Jeremy A. Pike, Christina Ernst, Nils Eling, Sarah J. Aitken
Publikováno v:
eLife
Ernst, C, Pike, J, Aitken, S J, Long, H K, Eling, N, Stojic, L, Ward, M C, Connor, F, Rayner, T F, Lukk, M, Klose, R J, Kutter, C & Odom, D T 2016, ' Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis ', eLIFE, vol. 5 . https://doi.org/10.7554/eLife.20235
eLife, Vol 5 (2016)
Ernst, C, Pike, J, Aitken, S J, Long, H K, Eling, N, Stojic, L, Ward, M C, Connor, F, Rayner, T F, Lukk, M, Klose, R J, Kutter, C & Odom, D T 2016, ' Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis ', eLIFE, vol. 5 . https://doi.org/10.7554/eLife.20235
eLife, Vol 5 (2016)
Most human aneuploidies originate maternally, due in part to the presence of highly stringent checkpoints during male meiosis. Indeed, male sterility is common among aneuploid mice used to study chromosomal abnormalities, and male germline transmissi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec56f67cb53a5d71d51bbcb1d6efd0a0
https://pubmed.ncbi.nlm.nih.gov/27855777
https://pubmed.ncbi.nlm.nih.gov/27855777