Výsledky vyhledávání - "Hannah K. Giannini"

SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia

Autor: Alexander Richard, Jung-Hyun Kim, Nathan Ungerleider, Johnny Tran, Hannah K. Giannini, Hyun Kyung Kong, Eun Young Park, Erik K. Flemington, Ssang-Taek Lim, Melody Baddoo, Lana Vukadin, Eun-Young Erin Ahn, Joshua K. Stone

Publikováno v: Cancer gene therapy

A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of individual genes remains elusive. Here, we report that S

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::185004724ca1328da5bf2e6afbb8d7a9
http://europepmc.org/articles/PMC8155101

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Hypoxia induces cancer cell-specific chromatin interactions and increases MALAT1 expression in breast cancer cells

Autor: Alexander Richard, Ssang-Taek Lim, Hannah K. Giannini, Jung-Hyun Kim, Ming Tan, Joshua K. Stone, Lana Vukadin, Eun-Young Erin Ahn

Publikováno v: J Biol Chem

Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA overexpressed in various cancers that promotes cell growth and metastasis. Although hypoxia has been shown to up-regulate MALAT1, only hypoxia-inducible factors (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::276e406a3d1ead36abb09069992cee77
https://doi.org/10.1074/jbc.ra118.006889

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