Výsledky vyhledávání - "Hannah K. Fandl"

Endothelial-derived extracellular vesicles from obese/hypertensive adults increase factors associated with hypertrophy and fibrosis in cardiomyocytes

Autor: Hannah K. Fandl, Vinicius P. Garcia, John W. Treuth, Lillian M. Brewster, Jared J. Greiner, Kevin P. Davy, Brian L. Stauffer, Christopher A. Desouza

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H675-H685

In the present study we determined the effect of endothelial microvesicles (EMVs) isolated from obese/hypertensive adults on mediators of cardiomyocyte hypertrophy [cardiac troponin T (cTnT), α-actinin, nuclear factor-kB (NF-kB)] and fibrosis [trans

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::25ac7bf9dd3d020db16c846431615633
https://doi.org/10.1152/ajpheart.00035.2023

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Differential Expression of Vascular-Related MicroRNA in Circulating Endothelial Microvesicles in Adults With Spinal Cord Injury: A Pilot Study

Autor: Andrew J. Park, Hannah K. Fandl, Vinicius P. Garcia, Geoff B. Coombs, Noah M. DeSouza, Jared J Greiner, Otto F. Barak, Tanja Mijacika, Zeljko Dujic, Philip N. Ainslie, Christopher A. DeSouza

Publikováno v: Topics in Spinal Cord Injury Rehabilitation. 29:34-42

Background Spinal cord injury (SCI) is associated with an increased risk and prevalence of cardiopulmonary and cerebrovascular disease-related morbidity and mortality. The factors that initiate, promote, and accelerate vascular diseases and events in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de3e5713746671e36c6d389548ff2712
https://doi.org/10.46292/sci22-00032

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Abstract 048: Extracellular Endothelial Microvesicles Causative Agents In Hypertension-related Endothelial Dysfunction

Autor: Vinicius P Garcia, Hannah K Fandl, Noah M DeSouza, Auburn R Berry, Jared J Greiner, Brian L Stauffer, Christopher A DeSouza

Publikováno v: Hypertension. 79

We have previously demonstrated that endothelial cell-derived microvesicles (EMVs) are elevated with hypertension and are associated with endothelial dysfunction. However, it is unknown whether EMVs play a causative role in blood pressure-related end

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a49c704694df17583d74c6fbbf331608
https://doi.org/10.1161/hyp.79.suppl_1.048

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Abstract P004: Chronic Nebivolol And Metoprolol Treatment Reduce Circulating Endothelial Cell-Derived Microvesicles In Adults With Hypertension

Autor: Hannah K Fandl, Christian S DeSouza, Vinicius P Garcia, Jared J Greiner, Brian L Stauffer, Christopher A Desouza

Publikováno v: Hypertension. 79

Nebivolol and metoprolol are effective blood pressure medications that also reduce risk of cardiovascular and cerebrovascular events. Endothelial cell-derived microvesicles (EMVs) are small anucleoid, extracellular vesicles released in response to a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::307038b033b72a180a94df509940e099
https://doi.org/10.1161/hyp.79.suppl_1.p004

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Abstract 14993: Dysfunctional Extracellular Microvesicles in Andean Highlanders With Excessive Erythrocytosis

Autor: Madden Brewster, Hannah K Fandl, Michael M. Tymko, Noah M DeSouza, Jared J. Greiner, Rachel Stone, Philip N. Ainslie, Anthony R Bain, Vinicius P Garcia, Francisco C. Villafuerte

Publikováno v: Circulation. 142

Background: Chronic mountain sickness, a maladaptation to high altitude (>2,500 m) characterized by excessive erythrocytosis (EE) and often severe hypoxemia, is prevalent in Andean highlanders. EE increases the risk of cardiovascular events and contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a4d6ed24e1e1c59c914a0dcfb017e736
https://doi.org/10.1161/circ.142.suppl_3.14993

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Abstract 16549: Trimethylamine N-Oxide-Derived Endothelial Microvesicles Induce a Dysfunctional Endothelial Cell Phenotype

Autor: Kevin P. Davy, Clay Rahaman, L. Madden Brewster, Kelly A Stockelman, Vinicius P Garcia, Jared J. Greiner, Lukas Maly, Hannah K Fandl, Christopher A. DeSouza

Publikováno v: Circulation. 142

Introduction: Gut microbiota-generated increases in trimethylamine N-oxide (TMAO) has been linked to atherosclerosis and major adverse cardiovascular events. Experimental and clinical studies suggest that TMAO impairs endothelial cell function result

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::abe7cd5c41da5b079fbeeec1ad7c5f5c
https://doi.org/10.1161/circ.142.suppl_3.16549

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Abstract MP26: Endothelial-derived Microvesicles From Andean Highlanders With Excessive Erythrocytosis Induce A Deleterious Cardiomyocyte Phenotype

Autor: Jared J. Greiner, Rachel Stone, Philip N. Ainslie, Anthony R Bain, Francisco C. Villafuerte, Michael M. Tymko, Vinicius P Garcia, Noah M DeSouza, Hannah K Fandl, Christopher A. DeSouza, L. Madden Brewster

Publikováno v: Hypertension. 76

Background: Excessive erythrocytosis (EE), defined as Hb ≥21 g/dL in men and ≥19 g/dL in women, is a pathologic consequence of residing at high altitude (>2500 m) and is common in Andean highlanders. EE is associated with increased cardiovascular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc6f6e0924c649180a1487f84e3b4490
https://doi.org/10.1161/hyp.76.suppl_1.mp26

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Abstract P069: Microvesicles From Enos-suppressed Endothelial Cells Induce Endothelial Cell Dysfunction

Autor: Lukas Maly, Jared J. Greiner, Madden Brewster, Hannah K Fandl, Christopher A. DeSouza, Clay Rahaman, Kelly A Stockelman, Jamie G. Hijmans, Vinicius P Garcia

Publikováno v: Hypertension. 76

Introduction: Endothelial nitric oxide synthase (eNOS) activity is critical to vascular health. Impaired eNOS activity and diminished NO production are common characteristics of a proatherogenic, dysfunctional endothelial phenotype that is associated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::cfa1663ceebd46d708e47620f15c851f
https://doi.org/10.1161/hyp.76.suppl_1.p069

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