Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Hannah J. Metcalfe"'
Publikováno v:
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Abstract Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophage
Externí odkaz:
https://doaj.org/article/09b47fcdd96e4fa1a53d1c199555dff0
Autor:
Marcus A Widdess, H. T. Claude Chan, Christine A Penfold, C Ian Mockridge, Tatyana Inzhelevskaya, Hannah J Metcalfe, Mark S Cragg, Aymen Al-Shamkhani
Publikováno v:
Cancer Immunology Research. 10:A26-A26
Immunostimulatory antibodies targeting co-stimulatory TNFRSF members have shown promise in pre-clinical cancer models, but this has not translated into clinical success, primarily due to lack of efficacy. Oligomerisation of the co-stimulatory molecul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef1cdf69b6b27eb52c8682950ade4ed
https://doi.org/10.1158/2326-6074.tumimm22-a26
https://doi.org/10.1158/2326-6074.tumimm22-a26
Autor:
Jonathan Plumb, Dave Singh, Hannah J. Metcalfe, Christian Beerli, Simon Lea, Chris Poll, Katharine Abbott-Banner
Publikováno v:
Lea, S, Metcalfe, H J, Plumb, J, Beerli, C, Poll, C, Singh, D & Abbott-Banner, K H 2016, ' Neutral sphingomyelinase-2, acid sphingomyelinase, and ceramide levels in COPD patients compared to controls ', International journal of chronic obstructive pulmonary disease, vol. 11, no. 1, pp. 2139-2147 . https://doi.org/10.2147/COPD.S95578
International Journal of Chronic Obstructive Pulmonary Disease
International Journal of Chronic Obstructive Pulmonary Disease
Simon R Lea,1,* Hannah J Metcalfe,1,* Jonathan Plumb,1 Christian Beerli,2 Chris Poll,3 Dave Singh,1 Katharine H Abbott-Banner3 1Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Cent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b081ce6e19ac822c4a59d385482f8d
https://doi.org/10.2147/copd.s95578
https://doi.org/10.2147/copd.s95578
Autor:
H. Martin Vordermeier, Efrain Guzman, Hannah J. Metcalfe, Sabine Steinbach, Ivan Morrison, Timothy Connelley, Lucia Biffar, Bernardo Villarreal-Ramos
Publikováno v:
Metcalfe, H J, Biffar, L, Steinbach, S, Guzman, E, Connelley, T, Morrison, I, Vordermeier, H M & Villarreal-Ramos, B 2018, ' Ag85A-specific CD4 T cell lines derived after boosting BCG-vaccinated cattle with Ad5-85A possess both mycobacterial growth inhibition and anti-inflammatory properties ', Vaccine, vol. 36, no. 20, pp. 2850-2854 . https://doi.org/10.1016/j.vaccine.2018.03.068
Vaccine
Vaccine
Highlights • BCG-primed, Ad5-85A boosted cattle present Ag85A specific mycobacteriocidal T cells. • Along with mycobacteriocidal activity Ad5-85A boosting induces IL-10 transcription. • Ad5-85A boosting does not alter the transcription pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::594981ed2fb1d85ae120a45f968588fb
https://www.pure.ed.ac.uk/ws/files/58836897/Ag85A_speci_c_CD4.pdf
https://www.pure.ed.ac.uk/ws/files/58836897/Ag85A_speci_c_CD4.pdf
Publikováno v:
Respiratory Research
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Khalaf, R M, Lea, S R, Metcalfe, H J & Singh, D 2017, ' Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi ', Respiratory research, vol. 18, no. 1, 61 . https://doi.org/10.1186/s12931-017-0539-4
Respiratory Research, Vol 18, Iss 1, Pp 1-10 (2017)
Khalaf, R M, Lea, S R, Metcalfe, H J & Singh, D 2017, ' Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi ', Respiratory research, vol. 18, no. 1, 61 . https://doi.org/10.1186/s12931-017-0539-4
Background Non-typeable Haemophilus influenza (NTHi) infection is common in COPD. Corticosteroids can have limited therapeutic effects in COPD patients. NTHi causes corticosteroid insensitive cytokine production from COPD alveolar macrophages. We inv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76ec16d14eac5a573f65e33db20f4565
https://pubmed.ncbi.nlm.nih.gov/28420398
https://pubmed.ncbi.nlm.nih.gov/28420398
Summary Chronic obstructive pulmonary disease (COPD) is characterized by an abnormal innate immune response. We have investigated the changes in the innate immune response of COPD alveolar macrophages exposed to both cigarette smoke and Toll-like rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb26fae24a6d91bcd36875b1fdf8b9a3
https://europepmc.org/articles/PMC4008991/
https://europepmc.org/articles/PMC4008991/
Autor:
Gareth Jones, W. Ivan Morrison, Hannah J. Metcalfe, Sabine Steinbach, Timothy Connelley, Bernardo Villarreal-Ramos, Martin Vordermeier
Publikováno v:
Vaccine
Metcalfe, H J, Steinbach, S, Jones, G J, Connelley, T, Morrison, W I, Vordermeier, M & Villarreal-ramos, B 2016, ' Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4+ T cells but no increase in avidity for Ag85A ', Vaccine, vol. 34, no. 38, pp. 4520-4525 . https://doi.org/10.1016/j.vaccine.2016.07.055
Metcalfe, H J, Steinbach, S, Jones, G J, Connelley, T, Morrison, W I, Vordermeier, M & Villarreal-ramos, B 2016, ' Protection associated with a TB vaccine is linked to increased frequency of Ag85A-specific CD4+ T cells but no increase in avidity for Ag85A ', Vaccine, vol. 34, no. 38, pp. 4520-4525 . https://doi.org/10.1016/j.vaccine.2016.07.055
Highlights • BCG-Ad5-85A protection was associated with higher CD4+ Ag85A-specific cell frequency. • BCG-Ad5-85A protection was not associated with increased CD4+ Ag85A-specific avidity. • BCG-Ad5-85A protection was not associated with epitope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9547c903319ff306ff8479ce3b906de