Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Hannah J. Gaunt"'
Autor:
Eulashini Chuntharpursat-Bon, Oleksandr V. Povstyan, Melanie J. Ludlow, David J. Carrier, Marjolaine Debant, Jian Shi, Hannah J. Gaunt, Claudia C. Bauer, Alistair Curd, T. Simon Futers, Paul D. Baxter, Michelle Peckham, Stephen P. Muench, Antony Adamson, Neil Humphreys, Sarka Tumova, Robin S. Bon, Richard Cubbon, Laeticia Lichtenstein, David J. Beech
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-18 (2023)
The PIEZO1 channel and the PECAM1 cell adhesion molecule interact and PIEZO1 cooperates with PECAM1 and CDH5 cell junctions during mechanical stress.
Externí odkaz:
https://doaj.org/article/ec77feaa25314fbeac8b7a91697307ac
Autor:
Baptiste Rode, Jian Shi, Naima Endesh, Mark J. Drinkhill, Peter J. Webster, Sabine J. Lotteau, Marc A. Bailey, Nadira Y. Yuldasheva, Melanie J. Ludlow, Richard M. Cubbon, Jing Li, T. Simon Futers, Lara Morley, Hannah J. Gaunt, Katarzyna Marszalek, Hema Viswambharan, Kevin Cuthbertson, Paul D. Baxter, Richard Foster, Piruthivi Sukumar, Andrew Weightman, Sarah C. Calaghan, Stephen B. Wheatcroft, Mark T. Kearney, David J. Beech
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The mechanisms that regulate the body’s response to exercise are poorly understood. Here, Rode et al. show that the mechanically activated cation channel Piezo1 is a molecular sensor of physical exercise in the endothelium that triggers endothelial
Externí odkaz:
https://doaj.org/article/7f62f67aa840473d94edc1b8db9c890a
Autor:
Katarzyna Marszalek, Raphael G. Slip, Hannah J. Gaunt, Lesley A. Wilson, Diego Sobradillo, Fiona Bartoli, Izzy Jayasinghe, David J. Beech, Katarina T. Miteva, Shruthi Deivasigamani, Lucia Pedicini, Lynn McKeown
Publikováno v:
Journal of Cell Biology. 218:2232-2246
Endothelial cells selectively release cargo stored in Weibel-Palade bodies (WPBs) to regulate vascular function, but the underlying mechanisms are poorly understood. Here we show that histamine evokes the release of the proinflammatory ligand, P-sele
Autor:
Peter J. Webster, Lara C Morley, James J. Walker, Nigel Simpson, Jian Shi, Adam J. Hyman, David J. Beech, Karen Forbes, Hannah J. Gaunt, Courtney Williams
Publikováno v:
Molecular Human Reproduction
Morley, L C, Shi, J, Gaunt, H J, Hyman, A J, Webster, P J, Williams, C, Forbes, K, Walker, J J, Simpson, N A B & Beech, D J 2018, ' Piezo1 channels are mechanosensors in human fetoplacental endothelial cells ', Molecular Human Reproduction, vol. 24, no. 10, pp. 510-520 . https://doi.org/10.1093/molehr/gay033
Morley, L C, Shi, J, Gaunt, H J, Hyman, A J, Webster, P J, Williams, C, Forbes, K, Walker, J J, Simpson, N A B & Beech, D J 2018, ' Piezo1 channels are mechanosensors in human fetoplacental endothelial cells ', Molecular Human Reproduction, vol. 24, no. 10, pp. 510-520 . https://doi.org/10.1093/molehr/gay033
STUDY QUESTION: Does the shear stress sensing ion channel subunit Piezo1 have an important mechanotransduction role in human fetoplacental endothelium?SUMMARY ANSWER: Piezo1 is present and functionally active in human fetoplacental endothelial cells,
Autor:
Lucia Pedicini, Katarina T. Miteva, Verity Hawley, Hannah J. Gaunt, Hollie L. Appleby, Richard M. Cubbon, Katarzyna Marszalek, Mark T. Kearney, David J. Beech, Lynn McKeown
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Endothelial barrier formation is maintained by intercellular communication through junctional proteins. The mechanisms involved in maintaining endothelial communication subsequent to barrier disruption remain unclear. It is known that low numbers of
Autor:
K. Raj Prasad, D. Burke, Peter J. Webster, David J. Beech, Hannah J. Gaunt, Anna Tiffany Littlejohns
Publikováno v:
Cell Cycle
AZD1775 is a small molecule WEE1 inhibitor used in combination with DNA-damaging agents to cause premature mitosis and cell death in p53-mutated cancer cells. Here we sought to determine the mechanism of action of AZD1775 in combination with chemothe
Autor:
Melanie J. Ludlow, Hannah J. Gaunt, Paul D. Baxter, Eulashini Chuntharpursat-Bon, Oleksandr V. Povstyan, David J. Beech
The discovery of Piezo1 channels as force sensors with roles in the endothelial response to fluid flow has appeared contradictory to earlier work suggesting mediation by a triad of cell adhesion molecules (CD31 and VE-cadherin) and vascular endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f173de857c49ae91c740ddef8a05227
https://doi.org/10.1101/602532
https://doi.org/10.1101/602532
Publikováno v:
European Biophysics Journal
Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca²+ entry because of the critical roles played by Ca²+ in many cell types, including cancer cells. There are several types of these
Autor:
Melanie J. Ludlow, David J. Beech, Alexander F. Bruns, Lea Radtke, Herbert Waldmann, Tobias Seitz, Mohamed S Amer, Sven Hahn, Mathias Christmann, Matthieu Willot, Hannah J. Gaunt, Naveen S. Vasudev, Slava Ziegler, Yasemin Akbulut, Katsuhiko Muraki
Publikováno v:
Angew Chem Int Ed Engl
Current therapies for common types of cancer such as renal cell cancer are often ineffective and unspecific, and novel pharmacological targets and approaches are in high demand. Here we show the unexpected possibility for the rapid and selective kill
Autor:
Richard A. Young, Adam J. Hyman, Hollie L. Appleby, Ollie Stokes, Sabrina Jansz, David J. Beech, Hannah J. Gaunt, Richard Foster
Publikováno v:
The FASEB Journal. 28