Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Hannah J Vaughan"'
Autor:
Hannah J. Vaughan, Savannah Est-Witte, Lance T. Dockery, Morgan A. Urello, Jonathan Boyd, Brittany D. Keyser, Li Zhuang, Marcello Marelli, R. James Christie
Publikováno v:
Science and Technology of Advanced Materials, Vol 25, Iss 1 (2024)
Targeted nanoparticles offer potential to selectively deliver therapeutics to cells; however, their subcellular fate following endocytosis must be understood to properly design mechanisms of drug release. Here we describe a nanoparticle platform and
Externí odkaz:
https://doaj.org/article/7e4104e7607a45dfa84961a88640e346
Autor:
Hannah J. Vaughan, Camila G. Zamboni, Nicholas P. Radant, Pranshu Bhardwaj, Esther Revai Lechtich, Laboni F. Hassan, Khalid Shah, Jordan J. Green
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss , Pp 377-388 (2021)
Despite initial promise, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based approaches to cancer treatment have yet to yield a clinically approved therapy, due to delivery challenges, a lack of potency, and drug resistance. To addr
Externí odkaz:
https://doaj.org/article/a6c099a709f14d6e9ad64f6140f6855c
Autor:
Hannah J Vaughan, Camila G Zamboni, Kathryn M Luly, Ling Li, Kathleen L Gabrielson, Laboni F Hassan, Nicholas P Radant, Pranshu Bhardwaj, Florin M Selaru, Martin G Pomper, Jordan J Green
Publikováno v:
International Journal of Nanomedicine.
Hannah J Vaughan,1,2 Camila G Zamboni,1,2 Kathryn M Luly,1,2 Ling Li,3 Kathleen L Gabrielson,4 Laboni F Hassan,1,2 Nicholas P Radant,1,2 Pranshu Bhardwaj,1,2 Florin M Selaru,3 Martin G Pomper,1,5,6 Jordan J Green1,2,6,7 1Department of Biomedical Engi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574cf6402b364d3fd81a2be2e4661695
https://www.dovepress.com/non-viral-gene-delivery-to-hepatocellular-carcinoma-via-intra-arterial-peer-reviewed-fulltext-article-IJN
https://www.dovepress.com/non-viral-gene-delivery-to-hepatocellular-carcinoma-via-intra-arterial-peer-reviewed-fulltext-article-IJN
Autor:
Camila Gadens Zamboni, Laboni F. Hassan, Nicholas P. Radant, Pranshu Bhardwaj, Esther Revai Lechtich, Khalid Shah, Hannah J. Vaughan, Jordan J. Green
Publikováno v:
Molecular Therapy: Oncolytics, Vol 21, Iss, Pp 377-388 (2021)
Molecular Therapy Oncolytics
Molecular Therapy Oncolytics
Despite initial promise, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based approaches to cancer treatment have yet to yield a clinically approved therapy, due to delivery challenges, a lack of potency, and drug resistance. To addr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51ae52c2df5b1c4a7ebdba7297155638
https://doi.org/10.1016/j.omto.2021.04.004
https://doi.org/10.1016/j.omto.2021.04.004
Autor:
Hannah J. Vaughan, Camila G. Zamboni, Laboni F. Hassan, Nicholas P. Radant, Desmond Jacob, Ronnie C. Mease, Il Minn, Stephany Y. Tzeng, Kathleen L. Gabrielson, Pranshu Bhardwaj, Xin Guo, David Francisco, Martin G. Pomper, Jordan J. Green
Publikováno v:
Science advances. 8(29)
Hepatocellular carcinoma (HCC) develops predominantly in the inflammatory environment of a cirrhotic liver caused by hepatitis, toxin exposure, or chronic liver disease. A targeted therapeutic approach is required to enable cancer killing without cau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2df54e5c5a186bd37eb152828a70abb
https://pubmed.ncbi.nlm.nih.gov/35857843
https://pubmed.ncbi.nlm.nih.gov/35857843
Autor:
Paula Schiapparelli, Kristen L. Kozielski, Jayoung Kim, Marissa Gionet-Gonzales, Stephany Y. Tzeng, Alfredo Quinones-Hinojosa, Hugo Guerrero-Cazares, Rawan Al-kharboosh, Hannah J. Vaughan, Yuxin Li, Alejandro Ruiz-Valls, Jordan J. Green, Casey Vantucci, Yuan Rui
Publikováno v:
Biomaterials
Novel treatments for glioblastoma (GBM) are urgently needed, particularly those which can simultaneously target GBM cells’ ability to grow and migrate. Herein, we describe a synthetic, bioreducible, biodegradable polymer that can package and delive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8942be9930c7f436aa2ec350695cc4e
https://doi.org/10.1016/j.biomaterials.2019.04.020
https://doi.org/10.1016/j.biomaterials.2019.04.020
Publikováno v:
J Control Release
Successful systemic gene delivery requires specific tissue targeting as well as efficient intracellular transfection. Increasingly, research laboratories are fabricating libraries of novel nanoparticles, engineering both new biomaterial structures an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fbb413bad787f963ec557cd3868375
https://pubmed.ncbi.nlm.nih.gov/34097924
https://pubmed.ncbi.nlm.nih.gov/34097924
Autor:
Hannah J. Vaughan, Jordan J. Green
Publikováno v:
Curr Opin Biomed Eng
There is great interest in developing gene therapies for many disease indications, including cancer. However, successful delivery of nucleic acids to tumor cells is a major challenge, and in vivo efficacy is difficult to predict. Cancer theranostics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::064237f609c2acbcaf9c21a58169c43c
https://doi.org/10.1016/j.cobme.2021.100300
https://doi.org/10.1016/j.cobme.2021.100300
Autor:
Hannah J. Vaughan, Maisa M. Nakata, Camila Gadens Zamboni, Kristen L. Kozielski, Jordan J. Green, Jayoung Kim, Martin G. Pomper, Luke J. Higgins
Publikováno v:
Journal of Controlled Release. 263:18-28
Hepatocellular carcinoma (HCC) is the third most deadly cancer in the US, with a meager 5-year survival rate of less than 20%. Such unfavorable numbers are closely related to the heterogeneity of the disease and the unsatisfactory therapies currently
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015577227229622fc27f39058bb30f51
https://doi.org/10.1016/j.jconrel.2017.03.384
https://doi.org/10.1016/j.jconrel.2017.03.384
Publikováno v:
Adv Mater
Nucleic acids are a promising type of therapeutic for the treatment of a wide range of conditions, including cancer, but they also pose many delivery challenges. For efficient and safe delivery to cancer cells, nucleic acids must generally be package
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca5f86a4bc4e705f4ae0700b6af218d7
https://europepmc.org/articles/PMC6923623/
https://europepmc.org/articles/PMC6923623/
